Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb
Research output: Contribution to journal › Journal article › peer-review
Standard
Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb. / Colquhoun, E Q; Hettiarachchi, M; Ye, J M; Richter, Erik A.; Hniat, A J; Rattigan, S; Clark, M G.
In: Life Sciences, Vol. 43, No. 21, 1988, p. 1747-1754.Research output: Contribution to journal › Journal article › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb
AU - Colquhoun, E Q
AU - Hettiarachchi, M
AU - Ye, J M
AU - Richter, Erik A.
AU - Hniat, A J
AU - Rattigan, S
AU - Clark, M G
PY - 1988
Y1 - 1988
N2 - Vasopressin and angiotensin II markedly stimulated oxygen uptake in the perfused rat hindlimb. The increase due to each agent approached 70% of the basal rate, and was greater than that produced by a maximal concentration of norepinephrine. Half-maximal stimulation occurred at 60 pM vasopressin, 0.5 nM angiotensin II and 10 nM norepinephrine. Angiotensins I and III were less potent than angiotensin II. For each agent, the dose-dependent increase in oxygen uptake coincided with a dose-dependent increase in perfusion pressure. The effects of both vasopressin and angiotensin to increase oxygen uptake and pressure were not inhibited by either phentolamine, propranolol or a combination of the two, but were completely inhibited by the vasodilator, nitroprusside. Nitroprusside also inhibited flow-induced increases in hindlimb oxygen uptake and perfusion pressure. The findings indicate a key role for the vascular system in the control of hindlimb oxygen uptake.
AB - Vasopressin and angiotensin II markedly stimulated oxygen uptake in the perfused rat hindlimb. The increase due to each agent approached 70% of the basal rate, and was greater than that produced by a maximal concentration of norepinephrine. Half-maximal stimulation occurred at 60 pM vasopressin, 0.5 nM angiotensin II and 10 nM norepinephrine. Angiotensins I and III were less potent than angiotensin II. For each agent, the dose-dependent increase in oxygen uptake coincided with a dose-dependent increase in perfusion pressure. The effects of both vasopressin and angiotensin to increase oxygen uptake and pressure were not inhibited by either phentolamine, propranolol or a combination of the two, but were completely inhibited by the vasodilator, nitroprusside. Nitroprusside also inhibited flow-induced increases in hindlimb oxygen uptake and perfusion pressure. The findings indicate a key role for the vascular system in the control of hindlimb oxygen uptake.
KW - Angiotensin I
KW - Angiotensin II
KW - Angiotensin III
KW - Animals
KW - Arginine Vasopressin
KW - Hindlimb
KW - Male
KW - Nitroprusside
KW - Norepinephrine
KW - Oxygen
KW - Oxygen Consumption
KW - Phentolamine
KW - Propranolol
KW - Rats
KW - Rats, Inbred Strains
KW - Reference Values
M3 - Journal article
C2 - 3193858
VL - 43
SP - 1747
EP - 1754
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 21
ER -
ID: 154757796