Prognosis of chronic pancreatitis: An international multicenter study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Prognosis of chronic pancreatitis : An international multicenter study. / Lowenfels, Albert B.; Maisonneuve, Patrick; Cavallini, Giorgio; W, Rudolf; Lankisch, Paul G.; Andersen, Jens Rikardt; DiMagno, Eugene P.; Andrén‐Sandberg, Åke; Domellöf, Lennart; Di Francesco, Vincenzo; Pederzoli, Paolo; Lühr‐Happe, Annette; Krag, Einar; Boyle, Peter; Pitchumoni, C. S.; Wynn, Pe Shein; Melton, L. Joseph.
In: The American Journal of Gastroenterology, Vol. 89, No. 9, 09.1994, p. 1467-1471.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Prognosis of chronic pancreatitis
T2 - An international multicenter study
AU - Lowenfels, Albert B.
AU - Maisonneuve, Patrick
AU - Cavallini, Giorgio
AU - W, Rudolf
AU - Lankisch, Paul G.
AU - Andersen, Jens Rikardt
AU - DiMagno, Eugene P.
AU - Andrén‐Sandberg, Åke
AU - Domellöf, Lennart
AU - Di Francesco, Vincenzo
AU - Pederzoli, Paolo
AU - Lühr‐Happe, Annette
AU - Krag, Einar
AU - Boyle, Peter
AU - Pitchumoni, C. S.
AU - Wynn, Pe Shein
AU - Melton, L. Joseph
N1 - (Ekstern)
PY - 1994/9
Y1 - 1994/9
N2 - Objectives: Tbe aim of this study was to determine which factors predict mortality in a cobort of patients with cbronic alcoholic and nonalcoholic pancreatitis. Patients with chronic pancreatitis are known to have a reduced life expectancy, but the quantitative relationship between various clinical features and survival is unclear. Methods: We evaluated survival among 2015 subjects with chronic pancreatitis treated at seven centers located in six countries. Results: Mean age at diagnosis was 46 ± 13 yr and mean duration of follow‐up was 7.4 ± 6.2 yr. Overall survival at 10 yr was 70% (95% confidence interval (CI), 68–73%) and at 20 yr was 45% (95% CI, 41–49%). Survival was significantly less than in the background population. There were 559 deaths observed among those with chronic pancreatitis compared with an expected number of 157.4, yielding a standardized mortality ratio (SMR) of 3.6 (95% CI, 3.3–3.9). Older subjects and those with alcoholic pancreatitis had a significant reduction in survival. In a mul‐tivariate analysis, mortality of middle‐aged and older subjects was 2.3 (95% CI, 1.8–2.8) and 6.3 (95% CI, 4.7–8.3) times greater than subjects less than 40 yr at diagnosis. Smoking (hazard ratio, 1.4; 95% CI, 1.0–1.9), drinking (hazard ratio, 1.6; 95% CI, 1.2–2.2), or development of cirrhosis (hazard ratio, 2.5; 95% CI, 2.0–3.2) increased the risk of death during the observation period, but we observed no survival difference in operated vs. nonoperated patients. Conclusions: Age at diagnosis, smoking, and drinking are major predictors of mortality in patients with chronic pancreatitis.
AB - Objectives: Tbe aim of this study was to determine which factors predict mortality in a cobort of patients with cbronic alcoholic and nonalcoholic pancreatitis. Patients with chronic pancreatitis are known to have a reduced life expectancy, but the quantitative relationship between various clinical features and survival is unclear. Methods: We evaluated survival among 2015 subjects with chronic pancreatitis treated at seven centers located in six countries. Results: Mean age at diagnosis was 46 ± 13 yr and mean duration of follow‐up was 7.4 ± 6.2 yr. Overall survival at 10 yr was 70% (95% confidence interval (CI), 68–73%) and at 20 yr was 45% (95% CI, 41–49%). Survival was significantly less than in the background population. There were 559 deaths observed among those with chronic pancreatitis compared with an expected number of 157.4, yielding a standardized mortality ratio (SMR) of 3.6 (95% CI, 3.3–3.9). Older subjects and those with alcoholic pancreatitis had a significant reduction in survival. In a mul‐tivariate analysis, mortality of middle‐aged and older subjects was 2.3 (95% CI, 1.8–2.8) and 6.3 (95% CI, 4.7–8.3) times greater than subjects less than 40 yr at diagnosis. Smoking (hazard ratio, 1.4; 95% CI, 1.0–1.9), drinking (hazard ratio, 1.6; 95% CI, 1.2–2.2), or development of cirrhosis (hazard ratio, 2.5; 95% CI, 2.0–3.2) increased the risk of death during the observation period, but we observed no survival difference in operated vs. nonoperated patients. Conclusions: Age at diagnosis, smoking, and drinking are major predictors of mortality in patients with chronic pancreatitis.
UR - http://www.scopus.com/inward/record.url?scp=0028027780&partnerID=8YFLogxK
U2 - 10.1111/j.1572-0241.1994.tb09160.x
DO - 10.1111/j.1572-0241.1994.tb09160.x
M3 - Journal article
C2 - 8079921
AN - SCOPUS:0028027780
VL - 89
SP - 1467
EP - 1471
JO - The American Journal of Gastroenterology
JF - The American Journal of Gastroenterology
SN - 0002-9270
IS - 9
ER -
ID: 251989719