Nuclear magnetic resonance-based metabolomics reveals that dairy protein fractions affect urinary urea excretion differently in overweight adolescents
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Nuclear magnetic resonance-based metabolomics reveals that dairy protein fractions affect urinary urea excretion differently in overweight adolescents. / Zheng, Hong; Yde, Christian C.; Dalsgaard, Trine K.; Arnberg, Karina; Mølgaard, Christian; Michaelsen, Kim F.; Larnkjær, Anni; Bertram, Hanne C.
In: European Food Research and Technology, Vol. 240, No. 3, 2015, p. 489-497.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Nuclear magnetic resonance-based metabolomics reveals that dairy protein fractions affect urinary urea excretion differently in overweight adolescents
AU - Zheng, Hong
AU - Yde, Christian C.
AU - Dalsgaard, Trine K.
AU - Arnberg, Karina
AU - Mølgaard, Christian
AU - Michaelsen, Kim F.
AU - Larnkjær, Anni
AU - Bertram, Hanne C.
N1 - CURIS 2015 NEXS 409
PY - 2015
Y1 - 2015
N2 - Dairy proteins are an important part of our diet, and recently, there is considerable focus on understanding the effects of the two major dairy proteins fractions constituted by casein and whey. In the present study, the impact of a dietary intervention with casein, whey, and skim milk was investigated by using NMR-based urine metabolomics. Overweight adolescents (n = 192; age = 12–15 years; BMI = 25.4 ± 2.3 kg/m2) were randomly assigned to 1 L/day of casein (citrate content: 3.27 mol/L), whey (citrate content: 0.04 mol/L), skim milk, or water for 12 weeks. A significant increase in the urinary excretion of urea was found after the 12-week casein and skim milk interventions, while the 12-week whey intervention had no significant effect on the urea excretion. In addition, NMR-based metabolomics revealed a decreased urinary citrate excretion in the whey group and thereby demonstrated its potential to disclosure exposure effects. In conclusion, the present study demonstrates that casein and whey proteins impact urinary urea excretion differently.
AB - Dairy proteins are an important part of our diet, and recently, there is considerable focus on understanding the effects of the two major dairy proteins fractions constituted by casein and whey. In the present study, the impact of a dietary intervention with casein, whey, and skim milk was investigated by using NMR-based urine metabolomics. Overweight adolescents (n = 192; age = 12–15 years; BMI = 25.4 ± 2.3 kg/m2) were randomly assigned to 1 L/day of casein (citrate content: 3.27 mol/L), whey (citrate content: 0.04 mol/L), skim milk, or water for 12 weeks. A significant increase in the urinary excretion of urea was found after the 12-week casein and skim milk interventions, while the 12-week whey intervention had no significant effect on the urea excretion. In addition, NMR-based metabolomics revealed a decreased urinary citrate excretion in the whey group and thereby demonstrated its potential to disclosure exposure effects. In conclusion, the present study demonstrates that casein and whey proteins impact urinary urea excretion differently.
KW - Casein
KW - Citrate
KW - Metabolomics
KW - Milk protein
KW - Urea
KW - Whey
U2 - 10.1007/s00217-014-2347-0
DO - 10.1007/s00217-014-2347-0
M3 - Journal article
AN - SCOPUS:84922565444
VL - 240
SP - 489
EP - 497
JO - European Food Research and Technology
JF - European Food Research and Technology
SN - 1438-2377
IS - 3
ER -
ID: 158210158