Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake?
Research output: Contribution to journal › Journal article › Research › peer-review
- Richter_American Journal of Physiology - Endocrinology and Metabolism_(2021)_(Accepted manuscript)
Accepted author manuscript, 1.07 MB, PDF document
Exercise increases muscle glucose uptake up to 100 fold compared to rest. The magnitude of increase depends on exercise intensity and duration. While KO of GLUT4 convincingly has shown that GLUT4 is necessary for exercise to increase muscle glucose uptake, studies only show an approximate 2-fold increase in GLUT4 translocation to the muscle cell membrane when transitioning from rest to exercise. Therefore, there is a big discrepancy between the increase in glucose uptake and GLUT4 translocation. It is suggested that either the methods for measurements of GLUT4 translocation in muscle grossly underestimate the real translocation of GLUT4 or alternatively that GLUT4 intrinsic activity increases in muscle during exercise, perhaps due to increased muscle temperature and/or mechanical effects during contraction/relaxation cycles.
|Journal||American Journal of Physiology: Endocrinology and Metabolism|
|Number of pages||4|
|Publication status||Published - 2021|
- Faculty of Science - Muscle glucose uptake, Exercise, GLUT4, Glucose transport, GLUT4 translocation