Intestinal Enterococcus abundance correlates inversely with excessive weight gain and increased plasma leptin in breastfed infants

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Intestinal Enterococcus abundance correlates inversely with excessive weight gain and increased plasma leptin in breastfed infants. / Laursen, Martin Frederik; Larsson, Melanie Wange; Lind, Mads Vendelbo; Larnkjær, Anni; Mølgaard, Christian; Michaelsen, Kim F.; Bahl, Martin Iain; Licht, Tine Rask.

In: F E M S Microbiology Ecology, Vol. 96, No. 5, fiaa066, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Laursen, MF, Larsson, MW, Lind, MV, Larnkjær, A, Mølgaard, C, Michaelsen, KF, Bahl, MI & Licht, TR 2020, 'Intestinal Enterococcus abundance correlates inversely with excessive weight gain and increased plasma leptin in breastfed infants', F E M S Microbiology Ecology, vol. 96, no. 5, fiaa066. https://doi.org/10.1093/femsec/fiaa066

APA

Laursen, M. F., Larsson, M. W., Lind, M. V., Larnkjær, A., Mølgaard, C., Michaelsen, K. F., Bahl, M. I., & Licht, T. R. (2020). Intestinal Enterococcus abundance correlates inversely with excessive weight gain and increased plasma leptin in breastfed infants. F E M S Microbiology Ecology, 96(5), [fiaa066]. https://doi.org/10.1093/femsec/fiaa066

Vancouver

Laursen MF, Larsson MW, Lind MV, Larnkjær A, Mølgaard C, Michaelsen KF et al. Intestinal Enterococcus abundance correlates inversely with excessive weight gain and increased plasma leptin in breastfed infants. F E M S Microbiology Ecology. 2020;96(5). fiaa066. https://doi.org/10.1093/femsec/fiaa066

Author

Laursen, Martin Frederik ; Larsson, Melanie Wange ; Lind, Mads Vendelbo ; Larnkjær, Anni ; Mølgaard, Christian ; Michaelsen, Kim F. ; Bahl, Martin Iain ; Licht, Tine Rask. / Intestinal Enterococcus abundance correlates inversely with excessive weight gain and increased plasma leptin in breastfed infants. In: F E M S Microbiology Ecology. 2020 ; Vol. 96, No. 5.

Bibtex

@article{7cdfbb918f3a4648a292c417d879cb7d,
title = "Intestinal Enterococcus abundance correlates inversely with excessive weight gain and increased plasma leptin in breastfed infants",
abstract = "Epidemiological evidence indicates that breastfeeding provides protection against development of overweight/obesity. Nonetheless, a small subgroup of infants undergo excessive weight gain during exclusive breastfeeding, a phenomenon that remains unexplained. Breast milk contains both gut-seeding microbes and substrates for microbial growth in the gut of infants, and a large body of evidence suggests a role for gut microbes in host metabolism. Based on the recently established SKOT III cohort, we investigated the role of the infant gut microbiota in excessive infant weight gain during breastfeeding, including 30 exclusively breastfed infants, 13 of which exhibited excessive weight gain and 17 controls which exhibited normal weight gain during infancy. Infants undergoing excessive weight gain during breastfeeding had a reduced abundance of gut Enterococcus as compared with that observed in the controls. Within the complete cohort, Enterococcus abundance correlated inversely with age/gender-adjusted body-weight, body-mass index and waist circumference, body fat and levels of plasma leptin. The reduced abundance of Enterococcus in infants with excessive weight gain was coupled to a lower content of Enterococcus in breast milk samples of their mothers than seen for mothers in the control group. Together, this suggests that lack of breast milk-derived gut-seeding Enterococci may contribute to excessive weight gain in breastfed infants.",
author = "Laursen, {Martin Frederik} and Larsson, {Melanie Wange} and Lind, {Mads Vendelbo} and Anni Larnkj{\ae}r and Christian M{\o}lgaard and Michaelsen, {Kim F.} and Bahl, {Martin Iain} and Licht, {Tine Rask}",
note = "{\textcopyright} FEMS 2020.",
year = "2020",
doi = "10.1093/femsec/fiaa066",
language = "English",
volume = "96",
journal = "F E M S Microbiology Ecology",
issn = "0168-6496",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Intestinal Enterococcus abundance correlates inversely with excessive weight gain and increased plasma leptin in breastfed infants

AU - Laursen, Martin Frederik

AU - Larsson, Melanie Wange

AU - Lind, Mads Vendelbo

AU - Larnkjær, Anni

AU - Mølgaard, Christian

AU - Michaelsen, Kim F.

AU - Bahl, Martin Iain

AU - Licht, Tine Rask

N1 - © FEMS 2020.

PY - 2020

Y1 - 2020

N2 - Epidemiological evidence indicates that breastfeeding provides protection against development of overweight/obesity. Nonetheless, a small subgroup of infants undergo excessive weight gain during exclusive breastfeeding, a phenomenon that remains unexplained. Breast milk contains both gut-seeding microbes and substrates for microbial growth in the gut of infants, and a large body of evidence suggests a role for gut microbes in host metabolism. Based on the recently established SKOT III cohort, we investigated the role of the infant gut microbiota in excessive infant weight gain during breastfeeding, including 30 exclusively breastfed infants, 13 of which exhibited excessive weight gain and 17 controls which exhibited normal weight gain during infancy. Infants undergoing excessive weight gain during breastfeeding had a reduced abundance of gut Enterococcus as compared with that observed in the controls. Within the complete cohort, Enterococcus abundance correlated inversely with age/gender-adjusted body-weight, body-mass index and waist circumference, body fat and levels of plasma leptin. The reduced abundance of Enterococcus in infants with excessive weight gain was coupled to a lower content of Enterococcus in breast milk samples of their mothers than seen for mothers in the control group. Together, this suggests that lack of breast milk-derived gut-seeding Enterococci may contribute to excessive weight gain in breastfed infants.

AB - Epidemiological evidence indicates that breastfeeding provides protection against development of overweight/obesity. Nonetheless, a small subgroup of infants undergo excessive weight gain during exclusive breastfeeding, a phenomenon that remains unexplained. Breast milk contains both gut-seeding microbes and substrates for microbial growth in the gut of infants, and a large body of evidence suggests a role for gut microbes in host metabolism. Based on the recently established SKOT III cohort, we investigated the role of the infant gut microbiota in excessive infant weight gain during breastfeeding, including 30 exclusively breastfed infants, 13 of which exhibited excessive weight gain and 17 controls which exhibited normal weight gain during infancy. Infants undergoing excessive weight gain during breastfeeding had a reduced abundance of gut Enterococcus as compared with that observed in the controls. Within the complete cohort, Enterococcus abundance correlated inversely with age/gender-adjusted body-weight, body-mass index and waist circumference, body fat and levels of plasma leptin. The reduced abundance of Enterococcus in infants with excessive weight gain was coupled to a lower content of Enterococcus in breast milk samples of their mothers than seen for mothers in the control group. Together, this suggests that lack of breast milk-derived gut-seeding Enterococci may contribute to excessive weight gain in breastfed infants.

U2 - 10.1093/femsec/fiaa066

DO - 10.1093/femsec/fiaa066

M3 - Journal article

C2 - 32275305

VL - 96

JO - F E M S Microbiology Ecology

JF - F E M S Microbiology Ecology

SN - 0168-6496

IS - 5

M1 - fiaa066

ER -

ID: 240793711