Intercorrelations of lipoprotein subfractions and their covariation with lifestyle factors in healthy men

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Intercorrelations of lipoprotein subfractions and their covariation with lifestyle factors in healthy men. / Parlesak, Alexandr; Eckoldt, Joachim; Winkler, Karl; Bode, Christian J.; Schäf̈er, Christian.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 54, No. 3, 2014, p. 174-180.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Parlesak, A, Eckoldt, J, Winkler, K, Bode, CJ & Schäf̈er, C 2014, 'Intercorrelations of lipoprotein subfractions and their covariation with lifestyle factors in healthy men', Journal of Clinical Biochemistry and Nutrition, vol. 54, no. 3, pp. 174-180. https://doi.org/10.3164/jcbn.13-78

APA

Parlesak, A., Eckoldt, J., Winkler, K., Bode, C. J., & Schäf̈er, C. (2014). Intercorrelations of lipoprotein subfractions and their covariation with lifestyle factors in healthy men. Journal of Clinical Biochemistry and Nutrition, 54(3), 174-180. https://doi.org/10.3164/jcbn.13-78

Vancouver

Parlesak A, Eckoldt J, Winkler K, Bode CJ, Schäf̈er C. Intercorrelations of lipoprotein subfractions and their covariation with lifestyle factors in healthy men. Journal of Clinical Biochemistry and Nutrition. 2014;54(3):174-180. https://doi.org/10.3164/jcbn.13-78

Author

Parlesak, Alexandr ; Eckoldt, Joachim ; Winkler, Karl ; Bode, Christian J. ; Schäf̈er, Christian. / Intercorrelations of lipoprotein subfractions and their covariation with lifestyle factors in healthy men. In: Journal of Clinical Biochemistry and Nutrition. 2014 ; Vol. 54, No. 3. pp. 174-180.

Bibtex

@article{119cf64501044e0088ab9c212fed885a,
title = "Intercorrelations of lipoprotein subfractions and their covariation with lifestyle factors in healthy men",
abstract = "So far, little is known about the effect of nutrition and lifestyle on the composition of circulating lipoprotein subfractions. In the current study, we measured the correlations among physical activity, nutrient intake, smoking, body-mass index (BMI), and age with the concentration of triglycerides, cholesterol, phospholipids, and apolipoproteins (ApoA1, ApoA2 and ApoB) in subfractions of LDL and HDL in 265 healthy working men. Concentrations of cholesterol, phospholipids, and ApoB in small, dense atherogenic LDL particles (sdLDL) correlated negatively (p<0.001) with those of cholesterol, phospholipids, and ApoA1 in HDL2, respectively. Age correlated positively with sdLDL while increasing BMI correlated with an atherogenic shift of cholesterol, phospholipids, and ApoB from large, buoyant LDL (lbLDL) to sdLDL and decreasing concentrations of HDL2 constituents. Physical activity and alcohol intake correlated negatively with sdLDL constituents and positively with HDL2 components. Consumption of monounsaturated fatty acids (MUFA) correlated with a lower ratio of sdLDL to HDL2 cholesterol. A favorable lipoprotein subfraction profile linked to a reduced risk of cardiovascular disease in men was associated with physical activity, moderate alcohol consumption, and dietary intake of MUFA, which might be exploited in future interventions for prevention of age- and BMI-associated atherogenic shifts of lipoprotein subfractions.",
keywords = "Atherogenic shift, Body-mass index, Lipoprotein subfractions, Nutrition, Small dense lipoprotein particles",
author = "Alexandr Parlesak and Joachim Eckoldt and Karl Winkler and Bode, {Christian J.} and Christian Sch{\"a}{\"f}er",
note = "(Ekstern)",
year = "2014",
doi = "10.3164/jcbn.13-78",
language = "English",
volume = "54",
pages = "174--180",
journal = "Journal of Clinical Biochemistry and Nutrition",
issn = "0912-0009",
publisher = "Institute of Applied Biochemistry",
number = "3",

}

RIS

TY - JOUR

T1 - Intercorrelations of lipoprotein subfractions and their covariation with lifestyle factors in healthy men

AU - Parlesak, Alexandr

AU - Eckoldt, Joachim

AU - Winkler, Karl

AU - Bode, Christian J.

AU - Schäf̈er, Christian

N1 - (Ekstern)

PY - 2014

Y1 - 2014

N2 - So far, little is known about the effect of nutrition and lifestyle on the composition of circulating lipoprotein subfractions. In the current study, we measured the correlations among physical activity, nutrient intake, smoking, body-mass index (BMI), and age with the concentration of triglycerides, cholesterol, phospholipids, and apolipoproteins (ApoA1, ApoA2 and ApoB) in subfractions of LDL and HDL in 265 healthy working men. Concentrations of cholesterol, phospholipids, and ApoB in small, dense atherogenic LDL particles (sdLDL) correlated negatively (p<0.001) with those of cholesterol, phospholipids, and ApoA1 in HDL2, respectively. Age correlated positively with sdLDL while increasing BMI correlated with an atherogenic shift of cholesterol, phospholipids, and ApoB from large, buoyant LDL (lbLDL) to sdLDL and decreasing concentrations of HDL2 constituents. Physical activity and alcohol intake correlated negatively with sdLDL constituents and positively with HDL2 components. Consumption of monounsaturated fatty acids (MUFA) correlated with a lower ratio of sdLDL to HDL2 cholesterol. A favorable lipoprotein subfraction profile linked to a reduced risk of cardiovascular disease in men was associated with physical activity, moderate alcohol consumption, and dietary intake of MUFA, which might be exploited in future interventions for prevention of age- and BMI-associated atherogenic shifts of lipoprotein subfractions.

AB - So far, little is known about the effect of nutrition and lifestyle on the composition of circulating lipoprotein subfractions. In the current study, we measured the correlations among physical activity, nutrient intake, smoking, body-mass index (BMI), and age with the concentration of triglycerides, cholesterol, phospholipids, and apolipoproteins (ApoA1, ApoA2 and ApoB) in subfractions of LDL and HDL in 265 healthy working men. Concentrations of cholesterol, phospholipids, and ApoB in small, dense atherogenic LDL particles (sdLDL) correlated negatively (p<0.001) with those of cholesterol, phospholipids, and ApoA1 in HDL2, respectively. Age correlated positively with sdLDL while increasing BMI correlated with an atherogenic shift of cholesterol, phospholipids, and ApoB from large, buoyant LDL (lbLDL) to sdLDL and decreasing concentrations of HDL2 constituents. Physical activity and alcohol intake correlated negatively with sdLDL constituents and positively with HDL2 components. Consumption of monounsaturated fatty acids (MUFA) correlated with a lower ratio of sdLDL to HDL2 cholesterol. A favorable lipoprotein subfraction profile linked to a reduced risk of cardiovascular disease in men was associated with physical activity, moderate alcohol consumption, and dietary intake of MUFA, which might be exploited in future interventions for prevention of age- and BMI-associated atherogenic shifts of lipoprotein subfractions.

KW - Atherogenic shift

KW - Body-mass index

KW - Lipoprotein subfractions

KW - Nutrition

KW - Small dense lipoprotein particles

U2 - 10.3164/jcbn.13-78

DO - 10.3164/jcbn.13-78

M3 - Journal article

AN - SCOPUS:84900431355

VL - 54

SP - 174

EP - 180

JO - Journal of Clinical Biochemistry and Nutrition

JF - Journal of Clinical Biochemistry and Nutrition

SN - 0912-0009

IS - 3

ER -

ID: 317459253