GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle

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The insulinotropic gut hormone, glucagon-like-peptide-1 (GLP-1) has been proposed to have effects on vascular function and glucose disposal. However, whether GLP-1 is able to increase microvascular recruitment (MVR) in humans has not been investigated. GLP-1 was infused in the femoral artery in overnight fasted healthy young men. Microvascular recruitment was measured with real time contrast-enhanced ultrasound and leg glucose uptake by the leg balance technique with and without inhibition of the insulinotropic response of GLP-1 by co-infusion of octreotide. As a positive control, MVR and leg glucose uptake were measured during a hyperinsulinemic euglycemic clamp. Infusion of GLP-1 caused a rapid increase (P
Original languageEnglish
JournalAmerican Journal of Physiology: Endocrinology and Metabolism
Issue number4
Pages (from-to)E355-E362
Number of pages8
Publication statusPublished - 2014

ID: 92062721