Genes controlling skeletal muscle glucose uptake and their regulation by endurance and resistance exercise
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Genes controlling skeletal muscle glucose uptake and their regulation by endurance and resistance exercise. / Verbrugge, Sander A J; Alhusen, Julia A; Kempin, Shimon; Pillon, Nicolas J; Rozman, Jan; Wackerhage, Henning; Kleinert, Maximilian.
In: Journal of Cellular Biochemistry, Vol. 123, No. 2, 2022, p. 202-214.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Genes controlling skeletal muscle glucose uptake and their regulation by endurance and resistance exercise
AU - Verbrugge, Sander A J
AU - Alhusen, Julia A
AU - Kempin, Shimon
AU - Pillon, Nicolas J
AU - Rozman, Jan
AU - Wackerhage, Henning
AU - Kleinert, Maximilian
N1 - Publisher Copyright: © 2021 The Authors.
PY - 2022
Y1 - 2022
N2 - Exercise improves the insulin sensitivity of glucose uptake in skeletal muscle. Due to that, exercise has become a cornerstone treatment for type 2 diabetes mellitus (T2DM). The mechanisms by which exercise improves skeletal muscle insulin sensitivity are, however, incompletely understood. We conducted a systematic review to identify all genes whose gain or loss of function alters skeletal muscle glucose uptake. We subsequently cross-referenced these genes with recently generated data sets on exercise-induced gene expression and signaling. Our search revealed 176 muscle glucose-uptake genes, meaning that their genetic manipulation altered glucose uptake in skeletal muscle. Notably, exercise regulates the expression or phosphorylation of more than 50% of the glucose-uptake genes or their protein products. This included many genes that previously have not been associated with exercise-induced insulin sensitivity. Interestingly, endurance and resistance exercise triggered some common but mostly unique changes in expression and phosphorylation of glucose-uptake genes or their protein products. Collectively, our work provides a resource of potentially new molecular effectors that play a role in the incompletely understood regulation of muscle insulin sensitivity by exercise.
AB - Exercise improves the insulin sensitivity of glucose uptake in skeletal muscle. Due to that, exercise has become a cornerstone treatment for type 2 diabetes mellitus (T2DM). The mechanisms by which exercise improves skeletal muscle insulin sensitivity are, however, incompletely understood. We conducted a systematic review to identify all genes whose gain or loss of function alters skeletal muscle glucose uptake. We subsequently cross-referenced these genes with recently generated data sets on exercise-induced gene expression and signaling. Our search revealed 176 muscle glucose-uptake genes, meaning that their genetic manipulation altered glucose uptake in skeletal muscle. Notably, exercise regulates the expression or phosphorylation of more than 50% of the glucose-uptake genes or their protein products. This included many genes that previously have not been associated with exercise-induced insulin sensitivity. Interestingly, endurance and resistance exercise triggered some common but mostly unique changes in expression and phosphorylation of glucose-uptake genes or their protein products. Collectively, our work provides a resource of potentially new molecular effectors that play a role in the incompletely understood regulation of muscle insulin sensitivity by exercise.
KW - Exercise metabolism
KW - Glucose uptake
KW - Insulin sensitivity
KW - Insulin signaling
KW - Resistance and endurance exercise
KW - Skeletal muscle
U2 - 10.1002/jcb.30179
DO - 10.1002/jcb.30179
M3 - Review
C2 - 34812516
AN - SCOPUS:85119662514
VL - 123
SP - 202
EP - 214
JO - Journal of supramolecular structure and cellular biochemistry
JF - Journal of supramolecular structure and cellular biochemistry
SN - 0733-1959
IS - 2
ER -
ID: 299197273