First-pass metabolism of ethanol in human beings: Effect of intravenous infusion of fructose

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

First-pass metabolism of ethanol in human beings : Effect of intravenous infusion of fructose. / Parlesak, Alexandr; Billinger, Michael Hans Ulrich; Schäfer, Christian; Wehner, Heinz Dieter; Bode, Christiane; Bode, Johann Christian.

In: Alcohol, Vol. 34, No. 2-3, 2004, p. 121-125.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Parlesak, A, Billinger, MHU, Schäfer, C, Wehner, HD, Bode, C & Bode, JC 2004, 'First-pass metabolism of ethanol in human beings: Effect of intravenous infusion of fructose', Alcohol, vol. 34, no. 2-3, pp. 121-125. https://doi.org/10.1016/j.alcohol.2004.06.009

APA

Parlesak, A., Billinger, M. H. U., Schäfer, C., Wehner, H. D., Bode, C., & Bode, J. C. (2004). First-pass metabolism of ethanol in human beings: Effect of intravenous infusion of fructose. Alcohol, 34(2-3), 121-125. https://doi.org/10.1016/j.alcohol.2004.06.009

Vancouver

Parlesak A, Billinger MHU, Schäfer C, Wehner HD, Bode C, Bode JC. First-pass metabolism of ethanol in human beings: Effect of intravenous infusion of fructose. Alcohol. 2004;34(2-3):121-125. https://doi.org/10.1016/j.alcohol.2004.06.009

Author

Parlesak, Alexandr ; Billinger, Michael Hans Ulrich ; Schäfer, Christian ; Wehner, Heinz Dieter ; Bode, Christiane ; Bode, Johann Christian. / First-pass metabolism of ethanol in human beings : Effect of intravenous infusion of fructose. In: Alcohol. 2004 ; Vol. 34, No. 2-3. pp. 121-125.

Bibtex

@article{3c6ff35b79b94803891ad50b8b69d73b,
title = "First-pass metabolism of ethanol in human beings: Effect of intravenous infusion of fructose",
abstract = "Intravenous infusion of fructose has been shown to enhance reduced form of nicotinamide adenine dinucleotide reoxidation and, thereby, to enhance the metabolism of ethanol. In the current study, the effect of fructose infusion on first-pass metabolism of ethanol was studied in human volunteers. A significantly higher first-pass metabolism of ethanol was obtained after administration of fructose in comparison with findings for control experiments with an equimolar dose of glucose. Because fructose is metabolized predominantly in the liver and can be presumed to have virtually no effects in the stomach, results of the current study support the assumption that only a negligible part of first-pass metabolism of ethanol occurs in the stomach.",
keywords = "Alcohol, Ethanol, First-pass metabolism, Fructose, Gastric, Liver",
author = "Alexandr Parlesak and Billinger, {Michael Hans Ulrich} and Christian Sch{\"a}fer and Wehner, {Heinz Dieter} and Christiane Bode and Bode, {Johann Christian}",
note = "(Ekstern) Funding Information: We are indebted to Dr. David G. Levitt for his generous support in the calculation of the pharmacokinetic values of ethanol catabolism with PKQuest. The study was generously supported by the Robert-Bosch-Foundation and by Deutsche Krebshilfe (70-1881-Bo 1).",
year = "2004",
doi = "10.1016/j.alcohol.2004.06.009",
language = "English",
volume = "34",
pages = "121--125",
journal = "Alcohol",
issn = "0741-8329",
publisher = "Elsevier",
number = "2-3",

}

RIS

TY - JOUR

T1 - First-pass metabolism of ethanol in human beings

T2 - Effect of intravenous infusion of fructose

AU - Parlesak, Alexandr

AU - Billinger, Michael Hans Ulrich

AU - Schäfer, Christian

AU - Wehner, Heinz Dieter

AU - Bode, Christiane

AU - Bode, Johann Christian

N1 - (Ekstern) Funding Information: We are indebted to Dr. David G. Levitt for his generous support in the calculation of the pharmacokinetic values of ethanol catabolism with PKQuest. The study was generously supported by the Robert-Bosch-Foundation and by Deutsche Krebshilfe (70-1881-Bo 1).

PY - 2004

Y1 - 2004

N2 - Intravenous infusion of fructose has been shown to enhance reduced form of nicotinamide adenine dinucleotide reoxidation and, thereby, to enhance the metabolism of ethanol. In the current study, the effect of fructose infusion on first-pass metabolism of ethanol was studied in human volunteers. A significantly higher first-pass metabolism of ethanol was obtained after administration of fructose in comparison with findings for control experiments with an equimolar dose of glucose. Because fructose is metabolized predominantly in the liver and can be presumed to have virtually no effects in the stomach, results of the current study support the assumption that only a negligible part of first-pass metabolism of ethanol occurs in the stomach.

AB - Intravenous infusion of fructose has been shown to enhance reduced form of nicotinamide adenine dinucleotide reoxidation and, thereby, to enhance the metabolism of ethanol. In the current study, the effect of fructose infusion on first-pass metabolism of ethanol was studied in human volunteers. A significantly higher first-pass metabolism of ethanol was obtained after administration of fructose in comparison with findings for control experiments with an equimolar dose of glucose. Because fructose is metabolized predominantly in the liver and can be presumed to have virtually no effects in the stomach, results of the current study support the assumption that only a negligible part of first-pass metabolism of ethanol occurs in the stomach.

KW - Alcohol

KW - Ethanol

KW - First-pass metabolism

KW - Fructose

KW - Gastric

KW - Liver

U2 - 10.1016/j.alcohol.2004.06.009

DO - 10.1016/j.alcohol.2004.06.009

M3 - Journal article

C2 - 15902905

AN - SCOPUS:14344264562

VL - 34

SP - 121

EP - 125

JO - Alcohol

JF - Alcohol

SN - 0741-8329

IS - 2-3

ER -

ID: 306558359