Enhanced muscle glucose metabolism after exercise: modulation by local factors
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Enhanced muscle glucose metabolism after exercise : modulation by local factors. / Richter, Erik A.; Garetto, L P; Goodman, M N; Ruderman, N B.
In: American Journal of Physiology (Consolidated), Vol. 246, No. 6 Pt 1, 1984, p. E476-E482.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Enhanced muscle glucose metabolism after exercise
T2 - modulation by local factors
AU - Richter, Erik A.
AU - Garetto, L P
AU - Goodman, M N
AU - Ruderman, N B
PY - 1984
Y1 - 1984
N2 - Studies in the rat suggest that after voluntary exercise there are two phases of glycogen repletion in skeletal muscle (preceding study). In phase I glucose utilization and glycogen synthesis are enhanced both in the presence and absence of insulin, whereas in phase II only the increase in the presence of insulin is found. To determine whether these alterations and in particular those mediated by insulin are due to local or systemic factors, one hindlimb of an anesthetized rat was electrically stimulated, and both hindlimbs were perfused immediately thereafter. Glucose and glycogen metabolism in the stimulated leg closely mimicked that observed previously after voluntary exercise on a treadmill. With no insulin added to the perfusate, glucose incorporation into glycogen was markedly enhanced in muscles that were glycogen depleted as were the uptake of 2-deoxyglucose and 3-O-methylglucose. Likewise, the stimulation of these processes by insulin was enhanced and continued to be so 2 h later when the muscles of the stimulated leg had substantially repleted their glycogen stores. The results suggest that the increases in insulin-mediated glucose utilization and glycogen synthesis in muscle after exercise are modulated by local contraction-induced factors.
AB - Studies in the rat suggest that after voluntary exercise there are two phases of glycogen repletion in skeletal muscle (preceding study). In phase I glucose utilization and glycogen synthesis are enhanced both in the presence and absence of insulin, whereas in phase II only the increase in the presence of insulin is found. To determine whether these alterations and in particular those mediated by insulin are due to local or systemic factors, one hindlimb of an anesthetized rat was electrically stimulated, and both hindlimbs were perfused immediately thereafter. Glucose and glycogen metabolism in the stimulated leg closely mimicked that observed previously after voluntary exercise on a treadmill. With no insulin added to the perfusate, glucose incorporation into glycogen was markedly enhanced in muscles that were glycogen depleted as were the uptake of 2-deoxyglucose and 3-O-methylglucose. Likewise, the stimulation of these processes by insulin was enhanced and continued to be so 2 h later when the muscles of the stimulated leg had substantially repleted their glycogen stores. The results suggest that the increases in insulin-mediated glucose utilization and glycogen synthesis in muscle after exercise are modulated by local contraction-induced factors.
KW - Adenosine Triphosphate
KW - Animals
KW - Deoxyglucose
KW - Electric Stimulation
KW - Glucose
KW - Glycogen
KW - Glycogen Synthase
KW - Hindlimb
KW - In Vitro Techniques
KW - Insulin
KW - Male
KW - Motor Activity
KW - Muscles
KW - Phosphocreatine
KW - Rats
KW - Rats, Inbred Strains
M3 - Journal article
C2 - 6430094
VL - 246
SP - E476-E482
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
SN - 0363-6143
IS - 6 Pt 1
ER -
ID: 154759647