Endothelial glycocalyx preservation - impact of nutrition and lifestyle
Research output: Contribution to journal › Review › Research › peer-review
Documents
- Francekovic & Gliemann_Nutrients_2023_Vol 15(11)_e2573_(Review)
Final published version, 3.29 MB, PDF document
The endothelial glycocalyx (eGC) is a dynamic hair-like layer expressed on the apical surface of endothelial cells throughout the vascular system. This layer serves as an endothelial cell gatekeeper by controlling the permeability and adhesion properties of endothelial cells, as well as by controlling vascular resistance through the mediation of vasodilation. Pathogenic destruction of the eGC could be linked to impaired vascular function, as well as several acute and chronic cardiovascular conditions. Defining the precise functions and mechanisms of the eGC is perhaps the limiting factor of the missing link in finding novel treatments for lifestyle-related diseases such as atherosclerosis, type 2 diabetes, hypertension, and metabolic syndrome. However, the relationship between diet, lifestyle, and the preservation of the eGC is an unexplored territory. This article provides an overview of the eGC's importance for health and disease and describes perspectives of nutritional therapy for the prevention of the eGC's pathogenic destruction. It is concluded that vitamin D and omega-3 fatty acid supplementation, as well as healthy dietary patterns such as the Mediterranean diet and the time management of eating, might show promise for preserving eGC health and, thus, the health of the cardiovascular system.
Original language | English |
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Article number | 2573 |
Journal | Nutrients |
Volume | 15 |
Issue number | 11 |
Number of pages | 20 |
ISSN | 2072-6643 |
DOIs | |
Publication status | Published - 2023 |
- Endothelial glycocalyx, Lifestyle diseases, Cardiovascular health, Obesity, Diabetes, Hypertension, Nutrition therapy, Mediterranean diet, Vitamin D, Dietary sulfur, Dietary nitrates, Mechanotransduction, Endotoxemia, Intermittent fasting
Research areas
ID: 357772309