EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle

Research output: Contribution to journalJournal articleResearchpeer-review

In mice, certain proteins show a highly confined expression in specific muscle groups. Also, resting and exercise/contraction-induced phosphorylation responses are higher in rat skeletal muscle with low mitochondrial content compared to muscles with high mitochondrial content, possibly related to differential reactive oxygen species (ROS)-scavenging ability or resting glycogen content. To evaluate these parameters in humans, biopsies from soleus, gastrocnemius and vastus lateralis muscles were taken before and after a 45 min inclined (15%) walking exercise bout at 69% VO2(max) aimed at simultaneously activating soleus and gastrocnemius in a comparable dynamic work-pattern. Hexokinase II and GLUT4 were 46-59% and 26-38% higher (p
Original languageEnglish
JournalP L o S One
Issue number2
Pages (from-to)e31054
Number of pages8
Publication statusPublished - 2012

    Research areas

  • Electromyography, Enzyme Activation, Exercise, Glucose Transporter Type 4, Hexokinase, Humans, Muscle, Skeletal, Phosphorylation, Protein Kinases, Signal Transduction

ID: 38565955