Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action

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Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action. / Kiens, Bente; Lithell, H; Mikines, K J; Richter, Erik A.

In: Journal of Clinical Investigation, Vol. 84, No. 4, 1989, p. 1124-1129.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Kiens, B, Lithell, H, Mikines, KJ & Richter, EA 1989, 'Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action', Journal of Clinical Investigation, vol. 84, no. 4, pp. 1124-1129. https://doi.org/10.1172/JCI114275

APA

Kiens, B., Lithell, H., Mikines, K. J., & Richter, E. A. (1989). Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action. Journal of Clinical Investigation, 84(4), 1124-1129. https://doi.org/10.1172/JCI114275

Vancouver

Kiens B, Lithell H, Mikines KJ, Richter EA. Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action. Journal of Clinical Investigation. 1989;84(4):1124-1129. https://doi.org/10.1172/JCI114275

Author

Kiens, Bente ; Lithell, H ; Mikines, K J ; Richter, Erik A. / Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action. In: Journal of Clinical Investigation. 1989 ; Vol. 84, No. 4. pp. 1124-1129.

Bibtex

@article{2a37d0eb9c7e411695bf42cbfab39417,
title = "Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action",
abstract = "The effects of exercise and a physiological increase in plasma insulin concentration on muscle lipoprotein lipase activity (mLPLA), leg exchange of glucose, and serum lipoprotein levels were investigated in healthy young men. During euglycemic hyperinsulinemia (n = 7) at 44 mU.liter-1, m-LPLA in non-exercised muscle decreased from 30 +/- 7.4 mU.g-1 wet weight (w.w.) (mean +/- SE) to 19 +/- 3.3 (P less than 0.05). Furthermore, the decrease in m-LPLA correlated closely (r = 0.97, P less than 0.05) with the increase in leg glucose uptake. Moreover, basal m-LPLA correlated with the insulin-induced increase in leg glucose uptake (r = 0.93, P less than 0.05). In the control group (n = 6) in which saline was infused in place of insulin and glucose, m-LPLA in nonexercised muscle did not change with time. No change in m-LPLA was observed immediately after one-legged knee extension exercise, but 4 h after exercise m-LPLA was higher (P less than 0.05) in the exercised thigh (47 +/- 17.8 mU.g-1 w.w.) compared with the contralateral nonexercised thigh (29 +/- 6.3 mU.g-1 w.w.). This difference was not found 8 h after exercise. The triacylglycerol content of serum lipoproteins decreased during insulin infusion. It is concluded that in contrast to the effect on adipose tissue, physiological concentrations of insulin decrease m-LPLA in proportion to the effect of insulin on muscle glucose uptake, while muscle contractions cause a local, delayed, and transient increase in m-LPLA. Further-more, basal m-LPLA is an indicator of muscle insulin sensitivity.",
keywords = "Adult, Blood Glucose, Cholesterol, Epinephrine, Exercise, Fatty Acids, Nonesterified, Glucose Clamp Technique, Glycerol, Hormones, Humans, Insulin, Lipoprotein Lipase, Lipoproteins, Male, Muscles, Norepinephrine",
author = "Bente Kiens and H Lithell and Mikines, {K J} and Richter, {Erik A.}",
year = "1989",
doi = "10.1172/JCI114275",
language = "English",
volume = "84",
pages = "1124--1129",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "American Society for Clinical Investigation",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action

AU - Kiens, Bente

AU - Lithell, H

AU - Mikines, K J

AU - Richter, Erik A.

PY - 1989

Y1 - 1989

N2 - The effects of exercise and a physiological increase in plasma insulin concentration on muscle lipoprotein lipase activity (mLPLA), leg exchange of glucose, and serum lipoprotein levels were investigated in healthy young men. During euglycemic hyperinsulinemia (n = 7) at 44 mU.liter-1, m-LPLA in non-exercised muscle decreased from 30 +/- 7.4 mU.g-1 wet weight (w.w.) (mean +/- SE) to 19 +/- 3.3 (P less than 0.05). Furthermore, the decrease in m-LPLA correlated closely (r = 0.97, P less than 0.05) with the increase in leg glucose uptake. Moreover, basal m-LPLA correlated with the insulin-induced increase in leg glucose uptake (r = 0.93, P less than 0.05). In the control group (n = 6) in which saline was infused in place of insulin and glucose, m-LPLA in nonexercised muscle did not change with time. No change in m-LPLA was observed immediately after one-legged knee extension exercise, but 4 h after exercise m-LPLA was higher (P less than 0.05) in the exercised thigh (47 +/- 17.8 mU.g-1 w.w.) compared with the contralateral nonexercised thigh (29 +/- 6.3 mU.g-1 w.w.). This difference was not found 8 h after exercise. The triacylglycerol content of serum lipoproteins decreased during insulin infusion. It is concluded that in contrast to the effect on adipose tissue, physiological concentrations of insulin decrease m-LPLA in proportion to the effect of insulin on muscle glucose uptake, while muscle contractions cause a local, delayed, and transient increase in m-LPLA. Further-more, basal m-LPLA is an indicator of muscle insulin sensitivity.

AB - The effects of exercise and a physiological increase in plasma insulin concentration on muscle lipoprotein lipase activity (mLPLA), leg exchange of glucose, and serum lipoprotein levels were investigated in healthy young men. During euglycemic hyperinsulinemia (n = 7) at 44 mU.liter-1, m-LPLA in non-exercised muscle decreased from 30 +/- 7.4 mU.g-1 wet weight (w.w.) (mean +/- SE) to 19 +/- 3.3 (P less than 0.05). Furthermore, the decrease in m-LPLA correlated closely (r = 0.97, P less than 0.05) with the increase in leg glucose uptake. Moreover, basal m-LPLA correlated with the insulin-induced increase in leg glucose uptake (r = 0.93, P less than 0.05). In the control group (n = 6) in which saline was infused in place of insulin and glucose, m-LPLA in nonexercised muscle did not change with time. No change in m-LPLA was observed immediately after one-legged knee extension exercise, but 4 h after exercise m-LPLA was higher (P less than 0.05) in the exercised thigh (47 +/- 17.8 mU.g-1 w.w.) compared with the contralateral nonexercised thigh (29 +/- 6.3 mU.g-1 w.w.). This difference was not found 8 h after exercise. The triacylglycerol content of serum lipoproteins decreased during insulin infusion. It is concluded that in contrast to the effect on adipose tissue, physiological concentrations of insulin decrease m-LPLA in proportion to the effect of insulin on muscle glucose uptake, while muscle contractions cause a local, delayed, and transient increase in m-LPLA. Further-more, basal m-LPLA is an indicator of muscle insulin sensitivity.

KW - Adult

KW - Blood Glucose

KW - Cholesterol

KW - Epinephrine

KW - Exercise

KW - Fatty Acids, Nonesterified

KW - Glucose Clamp Technique

KW - Glycerol

KW - Hormones

KW - Humans

KW - Insulin

KW - Lipoprotein Lipase

KW - Lipoproteins

KW - Male

KW - Muscles

KW - Norepinephrine

U2 - 10.1172/JCI114275

DO - 10.1172/JCI114275

M3 - Journal article

C2 - 2677048

VL - 84

SP - 1124

EP - 1129

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 4

ER -

ID: 154756607