Differences in the dietary requirement for vitamin D among Caucasian and East African women at Northern latitude
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Differences in the dietary requirement for vitamin D among Caucasian and East African women at Northern latitude. / Cashman, Kevin D; Ritz, Christian; Adebayo, Folasade A; Dowling, Kirsten G; Itkonen, Suvi T; Öhman, Taina; Skaffari, Essi; Saarnio, Elisa M; Kiely, Mairead; Allardt, Christel Lamberg.
In: European Journal of Nutrition, Vol. 58, No. 6, 2019, p. 2281-2291.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Differences in the dietary requirement for vitamin D among Caucasian and East African women at Northern latitude
AU - Cashman, Kevin D
AU - Ritz, Christian
AU - Adebayo, Folasade A
AU - Dowling, Kirsten G
AU - Itkonen, Suvi T
AU - Öhman, Taina
AU - Skaffari, Essi
AU - Saarnio, Elisa M
AU - Kiely, Mairead
AU - Allardt, Christel Lamberg
N1 - CURIS 2019 NEXS 267
PY - 2019
Y1 - 2019
N2 - Context: Current vitamin D recommendations have been established based on an assumption that there are no differences between Caucasian and other ethnic/racial groups in terms of vitamin D requirements. This assumption, largely made due to the absence of data, is a key knowledge gap identified by a number of authorities. Objective: To test whether the distribution of dietary requirements for maintaining winter serum 25-hydroxyvitamin D [25(OH)D] concentrations ≥ 30 nmol/L (a priority threshold linked to vitamin D deficiency prevention) differ between Caucasian and Somali women living at northerly latitude. Methods: We used data from a 5-month, winter-based, vitamin D3 dose-related randomized, placebo-controlled trial in Somali (n 47) and Causcian women (n 69), aged 21–64-year old, living in Southern Finland (60°N), to model the vitamin D intake–serum 25(OH)D dose–response relationship. Regression analyses were used to predict the vitamin D intake required to maintain 97.5% (as well as 50, 90, and 95%) of women in both ethnic groups above serum 25(OH)D thresholds of 30, 40 and 50 nmol/L. Results: Using a model which adjusted for baseline 25(OH)D, age, and BMI, the estimated vitamin D intake that maintained serum 25(OH)D ≥ 30 nmol/L in 97.5% of Caucasian and Somali women was 8 and 18 µg/day, respectively. Ethnic differences were also evident at 40 and 50 nmol/L serum 25(OH)D thresholds. Conclusion: The present study adds further evidence that ethnic differences in the dietary requirement for vitamin D do exist and that dose–response vitamin D intervention studies are required in at-risk target populations specified by ethnicity.
AB - Context: Current vitamin D recommendations have been established based on an assumption that there are no differences between Caucasian and other ethnic/racial groups in terms of vitamin D requirements. This assumption, largely made due to the absence of data, is a key knowledge gap identified by a number of authorities. Objective: To test whether the distribution of dietary requirements for maintaining winter serum 25-hydroxyvitamin D [25(OH)D] concentrations ≥ 30 nmol/L (a priority threshold linked to vitamin D deficiency prevention) differ between Caucasian and Somali women living at northerly latitude. Methods: We used data from a 5-month, winter-based, vitamin D3 dose-related randomized, placebo-controlled trial in Somali (n 47) and Causcian women (n 69), aged 21–64-year old, living in Southern Finland (60°N), to model the vitamin D intake–serum 25(OH)D dose–response relationship. Regression analyses were used to predict the vitamin D intake required to maintain 97.5% (as well as 50, 90, and 95%) of women in both ethnic groups above serum 25(OH)D thresholds of 30, 40 and 50 nmol/L. Results: Using a model which adjusted for baseline 25(OH)D, age, and BMI, the estimated vitamin D intake that maintained serum 25(OH)D ≥ 30 nmol/L in 97.5% of Caucasian and Somali women was 8 and 18 µg/day, respectively. Ethnic differences were also evident at 40 and 50 nmol/L serum 25(OH)D thresholds. Conclusion: The present study adds further evidence that ethnic differences in the dietary requirement for vitamin D do exist and that dose–response vitamin D intervention studies are required in at-risk target populations specified by ethnicity.
KW - Dietary reference values
KW - Ethnic-related differences
KW - RCT
KW - Vitamin D requirements
U2 - 10.1007/s00394-018-1775-1
DO - 10.1007/s00394-018-1775-1
M3 - Journal article
C2 - 30022296
AN - SCOPUS:85050240670
VL - 58
SP - 2281
EP - 2291
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6207
IS - 6
ER -
ID: 200289654