Contraction-associated translocation of protein kinase C in rat skeletal muscle

Research output: Contribution to journalJournal articleResearchpeer-review

Electrical stimulation of the sciatic nerve of the anaesthetized rat in vivo led to a time-dependent translocation of protein kinase C from the muscle cytosol to the particulate fraction. Maximum activity of protein kinase C in the particulate fraction occurred after 2 min of intermittent short tetanic contractions of the gastrocnemius-plantaris-soleus muscle group and coincided with the loss of activity from the cytosol. Translocation of protein kinase C may imply a role for this kinase in contraction-initiated changes in muscle metabolism.

Original languageEnglish
JournalFEBS letters
Volume217
Issue number2
Pages (from-to)232-236
Number of pages5
ISSN0014-5793
Publication statusPublished - 1987

    Research areas

  • Animals, Biological Transport, Calcium, Cytosol, Kinetics, Male, Muscle Contraction, Muscles, Phospholipids, Protein Kinase C, Rats, Rats, Inbred Strains, Subcellular Fractions

ID: 154757954