Association of sickle cell trait with β-cell dysfunction and physical activity in adults living with and without HIV in Tanzania
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Association of sickle cell trait with β-cell dysfunction and physical activity in adults living with and without HIV in Tanzania. / Kweka, Belinda V; Fredrick, Cyprian; Kitilya, Brenda; Jeremiah, Kidola; Lyimo, Eric; Filteau, Suzanne; Rehman, Andrea M; Friis, Henrik; Olsen, Mette Frahm; Faurholt-Jepsen, Daniel; Krogh-Madsen, Rikke; PrayGod, George.
In: APMIS - Journal of Pathology, Microbiology and Immunology, Vol. 130, No. 4, 2022, p. 230-239.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Association of sickle cell trait with β-cell dysfunction and physical activity in adults living with and without HIV in Tanzania
AU - Kweka, Belinda V
AU - Fredrick, Cyprian
AU - Kitilya, Brenda
AU - Jeremiah, Kidola
AU - Lyimo, Eric
AU - Filteau, Suzanne
AU - Rehman, Andrea M
AU - Friis, Henrik
AU - Olsen, Mette Frahm
AU - Faurholt-Jepsen, Daniel
AU - Krogh-Madsen, Rikke
AU - PrayGod, George
N1 - This article is protected by copyright. All rights reserved.
PY - 2022
Y1 - 2022
N2 - This study aimed to investigate sickle cell trait (SCT) associations with physical activity, markers of insulin secretion and resistance, and glucose among people living with HIV infection (PLWH), both antiretroviral therapy (ART) naïve and experienced, and HIV-uninfected adults. This was a cross-sectional study conducted in Mwanza, north-western Tanzania. We used data of 668 participants attained from two sub-studies of CICADA study. Mean age was 40 (SD 11.5) years, 402 (61.7 %) were females and 157 (24.1 %) had SCT. PLWH were 422 (64.7 %), of these, 80 (18.9 %) were on ART. People with SCT had higher risk of having an isolated β-cell dysfunction compared to those without SCT (RRR=1.82, CI: 1.10, 3.01, P=0.02). People with SCT but without HIV infection had lower average acceleration on the trunk longitudinal axis (ACCx) and higher level of self-reported physical activity. 30 min oral glucose tolerance test among PLWH on ART was higher in those with SCT compared to those without SCT. People with SCT are at higher risk of having β-cell dysfunction and those with SCT on ART are at more risk of developing diabetes. Future studies to investigate the interaction between SCT and HIV/ART on risk of diabetes should be considered.
AB - This study aimed to investigate sickle cell trait (SCT) associations with physical activity, markers of insulin secretion and resistance, and glucose among people living with HIV infection (PLWH), both antiretroviral therapy (ART) naïve and experienced, and HIV-uninfected adults. This was a cross-sectional study conducted in Mwanza, north-western Tanzania. We used data of 668 participants attained from two sub-studies of CICADA study. Mean age was 40 (SD 11.5) years, 402 (61.7 %) were females and 157 (24.1 %) had SCT. PLWH were 422 (64.7 %), of these, 80 (18.9 %) were on ART. People with SCT had higher risk of having an isolated β-cell dysfunction compared to those without SCT (RRR=1.82, CI: 1.10, 3.01, P=0.02). People with SCT but without HIV infection had lower average acceleration on the trunk longitudinal axis (ACCx) and higher level of self-reported physical activity. 30 min oral glucose tolerance test among PLWH on ART was higher in those with SCT compared to those without SCT. People with SCT are at higher risk of having β-cell dysfunction and those with SCT on ART are at more risk of developing diabetes. Future studies to investigate the interaction between SCT and HIV/ART on risk of diabetes should be considered.
KW - Faculty of Science
KW - Sickle cell trait
KW - HIV
KW - Antiretroviral therapy
KW - β-cell dysfunction and physical activity
U2 - 10.1111/apm.13214
DO - 10.1111/apm.13214
M3 - Journal article
C2 - 35167170
VL - 130
SP - 230
EP - 239
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 4
ER -
ID: 292138635