Following an application from Dextro Energy GmbH & Co. KG, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to glucose and “supports normal physical activity”. The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence. The food constituent that is the subject of the health claim is glucose, which is sufficiently characterised. The claimed effect is “supports normal physical activity”. The proposed target population is healthy, active, as well as endurance trained, men and women. The Panel notes that the claimed effect refers to the contribution of the food constituent to energy-yielding metabolism in active individuals. Energy-yielding metabolism is needed for all functions and activities of the body, including physical activity and exercise. The Panel considers that contribution to energy-yielding metabolism is a beneficial physiological effect. A claim on glucose and contribution to energy-yielding metabolism has already been assessed with a favourable outcome.