Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients
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Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients. / Kang, Eun Seok; Magkos, Faidon; Kim, Beom Seok; Zhai, Rihong; Su, Li; Kim, Yu Seun; Christiani, David C; Lee, Hyun Chul; Mantzoros, Christos S.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 1, 2012, p. E129-E135.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients
AU - Kang, Eun Seok
AU - Magkos, Faidon
AU - Kim, Beom Seok
AU - Zhai, Rihong
AU - Su, Li
AU - Kim, Yu Seun
AU - Christiani, David C
AU - Lee, Hyun Chul
AU - Mantzoros, Christos S
N1 - (Ekstern)
PY - 2012
Y1 - 2012
N2 - Context: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Adiponectin (ADIPOQ) and adiponectin receptor-1 (ADIPOR1) gene polymorphisms have been associated with type 2 diabetes. However, it is unknown whether these polymorphisms are also risk factors for PTDM.Objective: We investigated the association between PTDM and single-nucleotide polymorphisms of ADIPOQ and ADIPOR1 in a cohort of renal allograft recipients.Design, setting, and participants: Five hundred seventy-five patients (367 men and 208 women) who received kidney transplants between 1989 and 2007, without a history of diabetes and with a pretransplant fasting glucose concentration less than 5.5 mmol/liter. Patients were followed up for a median 10 yr. Genotypes included single-nucleotide polymorphisms of the following: ADIPOQ rs266729, rs822395, rs822396, rs2241766, and rs1501299 and ADIPOR1 rs2232853, rs12733285, and rs1342387.Results: TT-homozygotes in ADIPOQ rs1501299 [hazard ratio (HR) = 1.70, P = 0.032] had greater risk of PTDM after adjusting for age, sex, amount of weight gain, and type of immunosuppressant. There was a significant interaction between sex and ADIPOQ rs1501299 genotype (P = 0.037). In men, but not in women, TT-homozygotes in ADIPOQ rs1501299 were more likely to develop PTDM than the wild GG-homozygotes (HR = 2.50, P = 0.002), whereas GT-heterozygotes had nonsignificantly elevated risk (HR = 1.41, P = 0.128).Conclusion: Genetic variation in ADIPOQ rs1501299 is associated with PTDM in a sex-specific manner.
AB - Context: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Adiponectin (ADIPOQ) and adiponectin receptor-1 (ADIPOR1) gene polymorphisms have been associated with type 2 diabetes. However, it is unknown whether these polymorphisms are also risk factors for PTDM.Objective: We investigated the association between PTDM and single-nucleotide polymorphisms of ADIPOQ and ADIPOR1 in a cohort of renal allograft recipients.Design, setting, and participants: Five hundred seventy-five patients (367 men and 208 women) who received kidney transplants between 1989 and 2007, without a history of diabetes and with a pretransplant fasting glucose concentration less than 5.5 mmol/liter. Patients were followed up for a median 10 yr. Genotypes included single-nucleotide polymorphisms of the following: ADIPOQ rs266729, rs822395, rs822396, rs2241766, and rs1501299 and ADIPOR1 rs2232853, rs12733285, and rs1342387.Results: TT-homozygotes in ADIPOQ rs1501299 [hazard ratio (HR) = 1.70, P = 0.032] had greater risk of PTDM after adjusting for age, sex, amount of weight gain, and type of immunosuppressant. There was a significant interaction between sex and ADIPOQ rs1501299 genotype (P = 0.037). In men, but not in women, TT-homozygotes in ADIPOQ rs1501299 were more likely to develop PTDM than the wild GG-homozygotes (HR = 2.50, P = 0.002), whereas GT-heterozygotes had nonsignificantly elevated risk (HR = 1.41, P = 0.128).Conclusion: Genetic variation in ADIPOQ rs1501299 is associated with PTDM in a sex-specific manner.
KW - Adiponectin/genetics
KW - Adult
KW - Diabetes Mellitus/etiology
KW - Female
KW - Follow-Up Studies
KW - Gene Frequency
KW - Genetic Predisposition to Disease
KW - Genotype
KW - Humans
KW - Kidney Transplantation/adverse effects
KW - Male
KW - Middle Aged
KW - Polymorphism, Single Nucleotide/physiology
KW - Receptors, Adiponectin/genetics
KW - Sex Factors
KW - Transplantation, Homologous
U2 - 10.1210/jc.2011-1796
DO - 10.1210/jc.2011-1796
M3 - Journal article
C2 - 22049178
VL - 97
SP - E129-E135
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 1
ER -
ID: 290036519