Skeletal muscle glucose uptake during exercise: How is it regulated?
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Skeletal muscle glucose uptake during exercise : How is it regulated? / Rose, Adam John; Richter, Erik A.
In: Physiology, Vol. 20, No. 4, 2005, p. 260-270.Research output: Contribution to journal › Review › Research
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TY - JOUR
T1 - Skeletal muscle glucose uptake during exercise
T2 - How is it regulated?
AU - Rose, Adam John
AU - Richter, Erik A.
N1 - PUF 2005 5200 037
PY - 2005
Y1 - 2005
N2 - The increase in skeletal muscle glucose uptake during exercise results from a coordinated increase in rates of glucose delivery (higher capillary perfusion), surface membrane glucose transport, and intracellular substrate flux through glycolysis. The mechanism behind the movement of GLUT4 to surface membranes and the subsequent increase in transport by muscle contractions is largely unresolved, but it is likely to occur through intracellular signaling involving Ca2+-calmodulin-dependent protein kinase, 5'-AMP-activated protein kinase, and possibly protein kinase C.
AB - The increase in skeletal muscle glucose uptake during exercise results from a coordinated increase in rates of glucose delivery (higher capillary perfusion), surface membrane glucose transport, and intracellular substrate flux through glycolysis. The mechanism behind the movement of GLUT4 to surface membranes and the subsequent increase in transport by muscle contractions is largely unresolved, but it is likely to occur through intracellular signaling involving Ca2+-calmodulin-dependent protein kinase, 5'-AMP-activated protein kinase, and possibly protein kinase C.
U2 - 10.1152/physiol.00012.2005
DO - 10.1152/physiol.00012.2005
M3 - Review
C2 - 16024514
VL - 20
SP - 260
EP - 270
JO - Physiology
JF - Physiology
SN - 1548-9213
IS - 4
ER -
ID: 90675