Probiotics and child care absence due to infections: A randomized controlled trial
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Probiotics and child care absence due to infections : A randomized controlled trial. / Laursen, Rikke Pilmann; Larnkjær, Anni; Ritz, Christian; Hauger, Hanne; Michaelsen, Kim F.; Mølgaard, Christian.
In: Pediatrics, Vol. 140, No. 2, e20170735, 2017.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Probiotics and child care absence due to infections
T2 - A randomized controlled trial
AU - Laursen, Rikke Pilmann
AU - Larnkjær, Anni
AU - Ritz, Christian
AU - Hauger, Hanne
AU - Michaelsen, Kim F.
AU - Mølgaard, Christian
N1 - CURIS 2017 NEXS 195
PY - 2017
Y1 - 2017
N2 - OBJECTIVES: The risk of infections is higher in children attending child care compared with children cared for at home. This study examined the effect of a combination of probiotics on absence from child care because of respiratory and gastrointestinal infections in healthy infants aged 8 to 14 months at the time of enrollment in child care.METHODS: The ProbiComp study was a randomized, double-blind, placebo-controlled study. A total of 290 infants were randomly allocated to receive a placebo or a combination of Bifidobacterium animalis subsp lactis and Lactobacillus rhamnosus in a dose of 10(9) colony-forming units of each daily for a 6-month intervention period. Absence from child care, occurrence of infant symptoms of illness, and doctor visits were registered by the parents using daily and weekly Web-based questionnaires.RESULTS: Median absence from child care was 11 days (interquartile range: 6-16). Intention-to-treat analysis showed no difference between the probiotics and placebo groups (P = .19). Additionally, there was no difference in any of the secondary outcomes between groups; the number of children with doctor-diagnosed upper or lower respiratory tract infections, the number of doctor visits, antibiotic treatments, occurrence and duration of diarrhea, and days with common cold symptoms, fever, vomiting, or caregivers' absence from work.CONCLUSIONS: A daily administration of a combination of B animalis subsp lactis and L rhamnosus for 6 months did not reduce the number of days absent from child care in healthy infants at the time of enrollment in child care.
AB - OBJECTIVES: The risk of infections is higher in children attending child care compared with children cared for at home. This study examined the effect of a combination of probiotics on absence from child care because of respiratory and gastrointestinal infections in healthy infants aged 8 to 14 months at the time of enrollment in child care.METHODS: The ProbiComp study was a randomized, double-blind, placebo-controlled study. A total of 290 infants were randomly allocated to receive a placebo or a combination of Bifidobacterium animalis subsp lactis and Lactobacillus rhamnosus in a dose of 10(9) colony-forming units of each daily for a 6-month intervention period. Absence from child care, occurrence of infant symptoms of illness, and doctor visits were registered by the parents using daily and weekly Web-based questionnaires.RESULTS: Median absence from child care was 11 days (interquartile range: 6-16). Intention-to-treat analysis showed no difference between the probiotics and placebo groups (P = .19). Additionally, there was no difference in any of the secondary outcomes between groups; the number of children with doctor-diagnosed upper or lower respiratory tract infections, the number of doctor visits, antibiotic treatments, occurrence and duration of diarrhea, and days with common cold symptoms, fever, vomiting, or caregivers' absence from work.CONCLUSIONS: A daily administration of a combination of B animalis subsp lactis and L rhamnosus for 6 months did not reduce the number of days absent from child care in healthy infants at the time of enrollment in child care.
KW - Journal Article
U2 - 10.1542/peds.2017-0735
DO - 10.1542/peds.2017-0735
M3 - Journal article
C2 - 28674113
VL - 140
JO - Pediatrics
JF - Pediatrics
SN - 0031-4005
IS - 2
M1 - e20170735
ER -
ID: 181934932