Fatty acid profile of skeletal muscle phospholipids in trained and untrained young men
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Fatty acid profile of skeletal muscle phospholipids in trained and untrained young men. / Andersson, Agneta; Sjödin, Anders Mikael; Hedman, Anu; Olsson, Roger; Vessby, Bengt.
In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 279, No. 4, 2000, p. E744-E751.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Fatty acid profile of skeletal muscle phospholipids in trained and untrained young men
AU - Andersson, Agneta
AU - Sjödin, Anders Mikael
AU - Hedman, Anu
AU - Olsson, Roger
AU - Vessby, Bengt
PY - 2000
Y1 - 2000
N2 - Endurance trained (n = 14) and untrained young men (n = 15) were compared regarding the fatty acid profile of the vastus lateralis muscle after 8 wk on diets with a similar fatty acid composition. The skeletal muscle phospholipids in the trained group contained lower proportions of palmitic acid (16:0) (-12.4%, P < 0.001) and di-homo-γ-linolenic acid [20:3(n-6)] (-15.3%, P = 0.018), a lower n-6-to-n-3 ratio (-42.0%, P = 0.015), higher proportions of stearic acid (18:0) (+9.8%, P = 0.004) and sum of n-3 polyunsaturated fatty acids (+33.8%, P = 0.009), and a higher ratio between 20:4(n-6) to 20:3(n-6) (+18.4%, P = 0.006) compared with those in the untrained group. The group differences in 16:0, 20:3(n-6), 18:0/16:0, and 20:4(n-6)/20:3(n-6) were independent of fiber-type distribution. The trained group also showed a lower proportion of 16:0 (-7.9%, P < 0.001) in skeletal muscle triglycerides irrespective of fiber type. In conclusion, the fatty acid profile of the skeletal muscle differed between trained and untrained individuals, although the dietary fatty acid composition was similar. This difference was not explained by different fiber-type distribution alone but appears to be a direct consequence of changes in fatty acid metabolism due to the higher level of physical activity.
AB - Endurance trained (n = 14) and untrained young men (n = 15) were compared regarding the fatty acid profile of the vastus lateralis muscle after 8 wk on diets with a similar fatty acid composition. The skeletal muscle phospholipids in the trained group contained lower proportions of palmitic acid (16:0) (-12.4%, P < 0.001) and di-homo-γ-linolenic acid [20:3(n-6)] (-15.3%, P = 0.018), a lower n-6-to-n-3 ratio (-42.0%, P = 0.015), higher proportions of stearic acid (18:0) (+9.8%, P = 0.004) and sum of n-3 polyunsaturated fatty acids (+33.8%, P = 0.009), and a higher ratio between 20:4(n-6) to 20:3(n-6) (+18.4%, P = 0.006) compared with those in the untrained group. The group differences in 16:0, 20:3(n-6), 18:0/16:0, and 20:4(n-6)/20:3(n-6) were independent of fiber-type distribution. The trained group also showed a lower proportion of 16:0 (-7.9%, P < 0.001) in skeletal muscle triglycerides irrespective of fiber type. In conclusion, the fatty acid profile of the skeletal muscle differed between trained and untrained individuals, although the dietary fatty acid composition was similar. This difference was not explained by different fiber-type distribution alone but appears to be a direct consequence of changes in fatty acid metabolism due to the higher level of physical activity.
KW - Dietary fat
KW - Fiber type
KW - Insulin sensitivity
KW - Physical activity
KW - Triglycerides
U2 - 10.1152/ajpendo.2000.279.4.E744
DO - 10.1152/ajpendo.2000.279.4.E744
M3 - Journal article
C2 - 11001754
AN - SCOPUS:0033711731
VL - 279
SP - E744-E751
JO - A J P: Endocrinology and Metabolism (Online)
JF - A J P: Endocrinology and Metabolism (Online)
SN - 1522-1555
IS - 4
ER -
ID: 211152973