A weight-loss program adapted to the menstrual cycle increases weight loss in healthy, overweight, premenopausal women: A 6-mo randomized controlled trial
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A weight-loss program adapted to the menstrual cycle increases weight loss in healthy, overweight, premenopausal women : A 6-mo randomized controlled trial. / Geiker, Nina Rica Wium; Ritz, Christian; Pedersen, Sue D; Larsen, Thomas Meinert; Hill, James O; Astrup, Arne.
In: American Journal of Clinical Nutrition, Vol. 104, No. 1, 2016, p. 15-20.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A weight-loss program adapted to the menstrual cycle increases weight loss in healthy, overweight, premenopausal women
T2 - A 6-mo randomized controlled trial
AU - Geiker, Nina Rica Wium
AU - Ritz, Christian
AU - Pedersen, Sue D
AU - Larsen, Thomas Meinert
AU - Hill, James O
AU - Astrup, Arne
N1 - CURIS 2016 NEXS 150
PY - 2016
Y1 - 2016
N2 - Background: Hormonal fluctuations during the menstrual cycle influence energy intake and expenditure as well as eating preferences and behavior.Objective: We examined the impact of a diet and exercise weight-loss program that was designed to target and moderate the effects of the menstrual cycle compared with the effect of simple energy restriction.Design: A total of 60 healthy, overweight, premenopausal women were included in a 6-mo weight-loss program in which each subject consumed a diet of 1600 kcal/d. Subjects were randomly assigned to either a combined diet and exercise program that was tailored to metabolic changes of the menstrual cycle (Menstralean) or to undergo simple energy restriction (control).Results: Thirty-one women (19 Menstralean and 12 control women) completed the study [mean ± SD body mass index (in kg/m(2)): 32.0 ± 5.2]. Both groups lost weight during the study. In an intention-to-treat analysis, the Menstralean group did not achieve a clinically significant weight loss compared with that of the control group (P = 0.61). In per-protocol analyses, a more-pronounced weight loss of 4.3 ± 1.4 kg (P = 0.002) was shown in adherent Menstralean subjects than in the control group.Conclusion: A differentiated diet and exercise program that is tailored to counteract food cravings and metabolic changes throughout the menstrual cycle may increase weight loss above that achieved with a traditional diet and exercise program in women who can comply with the program. This trial was registered at clinicaltrials.gov as NCT01622114.
AB - Background: Hormonal fluctuations during the menstrual cycle influence energy intake and expenditure as well as eating preferences and behavior.Objective: We examined the impact of a diet and exercise weight-loss program that was designed to target and moderate the effects of the menstrual cycle compared with the effect of simple energy restriction.Design: A total of 60 healthy, overweight, premenopausal women were included in a 6-mo weight-loss program in which each subject consumed a diet of 1600 kcal/d. Subjects were randomly assigned to either a combined diet and exercise program that was tailored to metabolic changes of the menstrual cycle (Menstralean) or to undergo simple energy restriction (control).Results: Thirty-one women (19 Menstralean and 12 control women) completed the study [mean ± SD body mass index (in kg/m(2)): 32.0 ± 5.2]. Both groups lost weight during the study. In an intention-to-treat analysis, the Menstralean group did not achieve a clinically significant weight loss compared with that of the control group (P = 0.61). In per-protocol analyses, a more-pronounced weight loss of 4.3 ± 1.4 kg (P = 0.002) was shown in adherent Menstralean subjects than in the control group.Conclusion: A differentiated diet and exercise program that is tailored to counteract food cravings and metabolic changes throughout the menstrual cycle may increase weight loss above that achieved with a traditional diet and exercise program in women who can comply with the program. This trial was registered at clinicaltrials.gov as NCT01622114.
U2 - 10.3945/ajcn.115.126565
DO - 10.3945/ajcn.115.126565
M3 - Journal article
C2 - 27281304
VL - 104
SP - 15
EP - 20
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 1
ER -
ID: 162379533