A single bout of whole-body resistance exercise augments basal VLDL-triacylglycerol removal from plasma in healthy untrained men
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A single bout of whole-body resistance exercise augments basal VLDL-triacylglycerol removal from plasma in healthy untrained men. / Tsekouras, Yiannis E; Magkos, Faidon; Prentzas, Konstantinos I; Basioukas, Konstantinos N; Matsama, Stergoula G; Yanni, Amalia E; Kavouras, Stavros A; Sidossis, Labros S.
In: Clinical Science, Vol. 116, No. 2, 2009, p. 147-156.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - A single bout of whole-body resistance exercise augments basal VLDL-triacylglycerol removal from plasma in healthy untrained men
AU - Tsekouras, Yiannis E
AU - Magkos, Faidon
AU - Prentzas, Konstantinos I
AU - Basioukas, Konstantinos N
AU - Matsama, Stergoula G
AU - Yanni, Amalia E
AU - Kavouras, Stavros A
AU - Sidossis, Labros S
N1 - (Ekstern)
PY - 2009
Y1 - 2009
N2 - A single bout of prolonged aerobic exercise lowers plasma TAG (triacylglycerol) concentrations the next day by increasing the efficiency of VLDL (very-low-density lipoprotein)-TAG removal from the circulation. The effect of resistance exercise on VLDL-TAG metabolism is not known. Therefore we evaluated VLDL-TAG kinetics by using stable isotope-labelled tracers in eight healthy untrained men (age, 25.3+/-0.8 years; body mass index, 24.5+/-0.6 kg/m(2)) in the post-absorptive state in the morning on two separate occasions: once after performing a single 90-min bout of strenuous isokinetic resistance exercise (three sets x ten repetitions, 12 exercises at 80% of maximum peak torque production, with a 2-min rest interval between exercises) on the preceding afternoon and once after an equivalent period of rest. Fasting plasma VLDL-TAG concentrations in the morning after exercise were significantly lower than in the morning after rest (0.23+/-0.04 compared with 0.33+/-0.06 mmol/l respectively; P=0.001). Hepatic VLDL-TAG secretion rate was not different (P=0.31), but plasma clearance rate of VLDL-TAG was significantly higher (by 26+/-8%) after exercise than rest (31+/-3 compared with 25+/-3 ml/min respectively; P=0.004), and the mean residence time of VLDL-TAG in the circulation was significantly shorter (113+/-10 compared with 144+/-18 min respectively; P=0.02). Fasting plasma NEFA (non-esterified fatty acid; 'free' fatty acid) and serum beta-hydroxybutyrate concentrations were both significantly higher after exercise than rest (P<0.05), whereas plasma glucose and serum insulin concentrations were not different (P>0.30). We conclude that, in healthy untrained men, a single bout of whole-body resistance exercise lowers fasting plasma VLDL-TAG concentrations by augmenting VLDL-TAG removal from plasma. The effect appears to be qualitatively and quantitatively similar to that reported previously for aerobic exercise.
AB - A single bout of prolonged aerobic exercise lowers plasma TAG (triacylglycerol) concentrations the next day by increasing the efficiency of VLDL (very-low-density lipoprotein)-TAG removal from the circulation. The effect of resistance exercise on VLDL-TAG metabolism is not known. Therefore we evaluated VLDL-TAG kinetics by using stable isotope-labelled tracers in eight healthy untrained men (age, 25.3+/-0.8 years; body mass index, 24.5+/-0.6 kg/m(2)) in the post-absorptive state in the morning on two separate occasions: once after performing a single 90-min bout of strenuous isokinetic resistance exercise (three sets x ten repetitions, 12 exercises at 80% of maximum peak torque production, with a 2-min rest interval between exercises) on the preceding afternoon and once after an equivalent period of rest. Fasting plasma VLDL-TAG concentrations in the morning after exercise were significantly lower than in the morning after rest (0.23+/-0.04 compared with 0.33+/-0.06 mmol/l respectively; P=0.001). Hepatic VLDL-TAG secretion rate was not different (P=0.31), but plasma clearance rate of VLDL-TAG was significantly higher (by 26+/-8%) after exercise than rest (31+/-3 compared with 25+/-3 ml/min respectively; P=0.004), and the mean residence time of VLDL-TAG in the circulation was significantly shorter (113+/-10 compared with 144+/-18 min respectively; P=0.02). Fasting plasma NEFA (non-esterified fatty acid; 'free' fatty acid) and serum beta-hydroxybutyrate concentrations were both significantly higher after exercise than rest (P<0.05), whereas plasma glucose and serum insulin concentrations were not different (P>0.30). We conclude that, in healthy untrained men, a single bout of whole-body resistance exercise lowers fasting plasma VLDL-TAG concentrations by augmenting VLDL-TAG removal from plasma. The effect appears to be qualitatively and quantitatively similar to that reported previously for aerobic exercise.
KW - Adult
KW - Basal Metabolism/physiology
KW - Body Composition/physiology
KW - Diet
KW - Energy Metabolism/physiology
KW - Exercise/physiology
KW - Exercise Test/methods
KW - Fasting/blood
KW - Humans
KW - Insulin/blood
KW - Lipoproteins, VLDL/blood
KW - Male
KW - Oxygen Consumption/physiology
KW - Triglycerides/blood
KW - Young Adult
U2 - 10.1042/CS20080078
DO - 10.1042/CS20080078
M3 - Journal article
C2 - 18554182
VL - 116
SP - 147
EP - 156
JO - Clinical Science
JF - Clinical Science
SN - 0143-5221
IS - 2
ER -
ID: 290676212