PhD defence: Remote Functional Adaptations and Intercellular Crosstalk in the Human Vasculature

Insight from Ischemic Preconditioning and Exercise 

Nicolai Rytter Mortensen

PhD thesis

Impaired function of blood vessels and in particular the endothelium, which line the luminal surface, is intrinsic to cardiovascular events and lifestyle related diseases. Several therapeutic strategies are known to promote cardiovascular health by improving the function of blood vessels.

Here, the innovative procedure of ischemic preconditioning and the proven approach of physical activity was studied, with the objective to examine remote functional adaptations related to endothelial function, formation of blood clots and intercellular crosstalk mediated by platelets in the human vasculature.

The seminal findings from the present thesis provide evidence that ischemic preconditioning potently leads to functional adaptations in remote vascular tissue, in particular the endothelium, and also that it influences the proteome profile of platelets.

Importantly, the findings also imply that the therapeutic strategies which was studied should be prescribed only on the basis of a thorough prior assessment of eligibility.

2020, 155 pages.

Time

27 August 2020, 14:00

Place

Festauditoriet 1-01, Bülowsvej 17. 1870 Frederiksberg C

Digital: To attend the PhD defence, follow the link and hereafter the instructions to download the required Zoom-client.

Opponents

Associate Professor Anke Ninija Karbanov (chair), Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.

Professor Stefan Mortensen, University of Southern Denmark, Denmark.

Professor Mike Tschakovsky, Queens University, Canada.

Supervisor

Professor Ylva Hellsten, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.

Co-supervisors

Associate professor Lasse Gliemann, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.