PhD defence: The Role of Angiopoietin-like protein 4 in Obesity and Obesity-related diseases

Trine Blædel

PhD thesis

ANGPTL4 is a lipoprotein lipase inhibitor that has been suggested to be involved in lipid metabolism and in the pathogenesis of obesity-related diseases such as type 2 diabetes, cardiovascular disease and cancer.

The thesis investigates whether ANGPTL4 concentration in plasma can be modified by a moderate dietary intervention with whole fat milk or with inulin fiber.

Furthermore, data from three intervention studies were analyzed in order to investigate the effects of genetic variants, weight loss and weight maintenance on ANGPTL4.

2016, 125 pages.

Time

10 March 2017, 13:00

Place

Auditorium A2-70.04, Thorvaldsensvej 40, 1870 Frederiksberg C.

Opponents 

Associate Professor Lotte Lauritzen (chair), Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.

Professor Ulla Vogel, National Research Centre for the Working Environment, Denmark.

Associate Professor Lydia Afman, WU Agrotechnology and Food Sciences, The Netherlands.

Supervisor

Associate Professor Lesli Hingstrup Larsen, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.

Co supervisor

Professor Arne Astrup, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.