PhD defence - Benedikte Grenov
Benedikte Grenov is defending her PhD thesis
The effect of probiotics on diarrhea in children with severe acute malnutrition - an intervention study in Uganda
16 December 2016, 13:00
Festauditoriet 1-01, Bülowsvej 17, 1870 Frederiksberg
Professor Anders Sjödin (chair), Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark
Dr. Iva Hojsak, Children’s hospital Zagreb, Croatia
Pr. Alan Jackson, University Hospital Southampton, UK
Professor Kim Fleischer Michaelsen, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark
Professor Henrik Friis, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark
Professor Christian Mølgaard, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark
About the thesis
Every year 0.5 to 1 million children below 5 years of age die from severe acute malnutrition in low-income countries, and diarrhea is one of the most common causes for mortality. At the university hospital of Kampala, Uganda, we investigated if two probiotic strains, LGG and BB-12, could reduce diarrhea in children with SAM during hospitalization and the subsequent outpatient treatment.
A randomized, double-blind, placebo-controlled study was conducted among 400 children with SAM. The results showed that probiotics did not have any effect on the number of days with diarrhea during hospitalization; however, during outpatient treatment probiotics reduced days with diarrhea by 26%. There was no difference between the probiotic and placebo groups on other outcomes or mortality.
2016, 169 pages