PhD defence: Vascular function and angiogenesis in aging and essential hypertension

Adaptive response to physical activity and resveratrol supplementation

Lasse Gliemann Hybholt

PhD thesis

Aging and physical inactivity are associated with decreased vascular function and physical capacity which may affect quality of life.

The results from present thesis show that physical capacity and vascular function are improved after a relatively short period of physical activity in both inactive aged men and subjects with high blood pressure. These improvements in the cardiovascular system are partly due to improved regulation of vasodilating substances and alterations in the capillary network.

This thesis also suggest that, although the ”red wine-antioxidant” resveratrol has been proven effective in improving cardiovascular health in rats and mice, this is not the case when resveratrol is given to aged men.

2014, 91 pages,
ISBN 978 87 7611 805 1

Time

13 November 2014, 14:00

Venue

Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen.

Opponents

Professor Erik A. Richter (chair), Department of Nutrition, Exercise and Sports, University of Copnhagen, Denmark.

Professor Carl-Johan Sundberg, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.

Professor Malcolm Jackson, Institute of Ageing and Chronic Disease, Faculty of Health and Life Sciences, University of Liverpool, England.

Supervisor

Professor Ylva Hellsten, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.