PhD defence - Stine Just Maarbjerg

Stine Just Maarbjerg is defending her PhD-thesis 

Role of AMPK and LKB1 in contraction and exercise induced muscle glucose uptake

Time

Friday July 1, 2011 at 14.00 o'clock

Place

Auditorium 1, August Krogh building, Universitetsparken 13, Copenhagen

Opponents

Professor Ylva Hellsten (chair), Department of Exercise and Sport Sciences, University of Copenhagen, Denmark

Professor Jørgen Jensen, Norwegian School of Sport Sciences, Oslo, Norway

Doctor Kei Sakamoto, MRC Protein Phosphorylation Unit, The Sir James Black Centre, University of Dundee, United Kingdom

Supervisor

Professor Erik A. Richter, Department of Exercise and Sport Sciences, Faculty of Science, University of Copenhagen, Denmark

Role of AMPK and LKB1 in contraction and exercise induced muscle glucose uptake

Physical exercise increases muscle glucose uptake and thereby potentially mediates a beneficial lowering of blood glucose levels in people with type 2 diabetes.

Despite the great therapeutic potential of this anti-diabetic effect, the mechanisms responsible remain unresolved. However especially two molecules, which are so-called protein kinases, have caught great attention. These two protein kinases are AMP-activated protein kinase (AMPK) and the upstream kinase of AMPK, LKB1.

This PhD thesis aims to explore the role of AMPK and LKB1 during muscle contraction and physiological exercise via application of three different transgenic mouse models with impaired AMPK and LKB1 signaling in muscle.

Read more about the thesis.