PhD defence - Nina Brandt

Nina Brandt is defending her PhD-thesis 

Mechanisms of insulin resistance – the effect of exercise


Friday May 13, 2011 at 13.00 o'clock


Auditorium 1, August Krogh building, Universitetsparken 13, Copenhagen


Professor Ylva Hellsten (chair), Department of Exercise and Sport Sciences, University of Copenhagen, Denmark

Professor Matthew Watt, Biology of Lipid Metabolism Group Department of Physiology, Monash University Clayton, Victoria, Australia.

Professor Mark A. Febbraio PhD, Head, Cellular & Molecular Metabolism Laboratory, Head of Basic Science, Division of Metabolism & Obesity, Baker IDI Heart and Diabetes Institute, Melbourne, Australia. 


Professor Erik A. Richter, Department of Exercise and Sport Sciences, Faculty of Science, University of Copenhagen, Denmark

Mechanisms of insulin resistance - the effect of exercise

Due to a sedentary lifestyle, the prevalence of Type 2 Diabetes is increasing at alarming rates worldwide. Insulin resistance, defined as decreased ability of insulin to regulate glucose uptake in multiple organs including skeletal muscle is a key event in the development of Type 2 Diabetes. Acute exercise and training both ameliorate insulin resistance, while the underlying mechanisms are yet to be defined.

This ph.d.-thesis brings the obtained research results from 3 studies together with the current knowledge in the field of insulin signaling and insulin resistance.

The impact of an oversupply of energy, either as carbohydrates or fat, on both proximal and distal components in the insulin signaling cascade as well as the impact of exercise on insulin action in insulin sensitive and insulin resistant states are presented. Furthermore, activation of an alternative signaling pathway via leukemia inhibitory factor (LIF) was demonstrated, allowing for preservation of glucose uptake in insulin resistant white skeletal muscle.

Read more about the thesis.