PhD defence - Ane Håkansson Hansen

The impact of training and exercise on vascular growth and peripheral vascular function in skeletal muscle of subjects with essential hypertension

Essential hypertension is a cardiovascular disease with no simple identifiable cause and the underlying mechanisms are still unclear. In general, the elevation of the blood pressure includes a major risk factor for myocardial infarction and stroke. The present thesis examined the effects of acute exercise and regular training in hypertensive subjects. The thesis covers 3 main areas: 1) vascular growth, 2) regulation of peripheral vascular function and 3) capillary basement membrane remodelling. These areas were examined in skeletal muscle in subjects participating in a four month training program

The major novel finding of this thesis is that a period of regular training is associated with improved angiogenic potential, enhanced vascular growth and improved vascular function. These alterations are paralleled by a lowering of blood pressure indicating a beneficial effect of training that may be associated with improving the regulation of total peripheral resistance.

Time

September 8, 2010 at 14.00

Place

Store Auditorium, Department of Exercise and Sport Sciences, University of Copenhagen, Nørre Alle 51, DK-2200 Copenhagen N, Denmark

Opponents

Professor Hans Hoppeler, Institute of Anatomy, University of Bern, Switzerland.

Associate professor Peter Busk, Copenhagen Institute of Technology, Aalborg University, Denmark.

Associate professor Bente Rona Jensen, Department of Exercise and Sport Sciences, Faculty of Science, University of Copenhagen, Denmark (chairman).

Supervisor

Professor Ylva Hellsten, Department of Exercise and Sport Sciences, Faculty of Science, University of Copenhagen, Denmark