PhD defence - Ane Håkansson Hansen
The impact of training and exercise on vascular growth and peripheral vascular function in skeletal muscle of subjects with essential hypertension
Essential hypertension is a cardiovascular disease with no simple identifiable cause and the underlying mechanisms are still unclear. In general, the elevation of the blood pressure includes a major risk factor for myocardial infarction and stroke. The present thesis examined the effects of acute exercise and regular training in hypertensive subjects. The thesis covers 3 main areas: 1) vascular growth, 2) regulation of peripheral vascular function and 3) capillary basement membrane remodelling. These areas were examined in skeletal muscle in subjects participating in a four month training program
The major novel finding of this thesis is that a period of regular training is associated with improved angiogenic potential, enhanced vascular growth and improved vascular function. These alterations are paralleled by a lowering of blood pressure indicating a beneficial effect of training that may be associated with improving the regulation of total peripheral resistance.
September 8, 2010 at 14.00
Store Auditorium, Department of Exercise and Sport Sciences, University of Copenhagen, Nørre Alle 51, DK-2200 Copenhagen N, Denmark
Professor Hans Hoppeler, Institute of Anatomy, University of Bern, Switzerland.
Associate professor Peter Busk, Copenhagen Institute of Technology, Aalborg University, Denmark.
Associate professor Bente Rona Jensen, Department of Exercise and Sport Sciences, Faculty of Science, University of Copenhagen, Denmark (chairman).
Professor Ylva Hellsten, Department of Exercise and Sport Sciences, Faculty of Science, University of Copenhagen, Denmark
Exercise and vascular function
PhD thesis by
Ane Håkansson Hansen
2010, 123 p., DKR 100,-