Illuminating novel molecular mechanisms of human skeletal muscle insulin sensitivity using personalised phosphoproteomics

illustration
Schematic representation of the pathway identified in the present thesis, illustrating how mTORC1–MKNK2–eIF4G1 signaling exerts negative feedback on insulin-stimulated glucose uptake in skeletal muscle.

PhD defence

Magnus Romme Leandersson

Exercise enhances the effects of the hormone insulin in skeletal muscle, making it a cornerstone for preventing and managing insulin resistance (prediabetes) and Type 2 diabetes.

However, because regular exercise is not always feasible or sustained, developing pharmacological therapies that replicate these metabolic benefits has become a major clinical goal. 

Designing such treatments requires identification of the responsible molecular mechanisms.

This thesis applies a state-of-the-art approach termed "personalised phosphoproteomics" to study these mechanisms in human skeletal muscle. The findings uncover key targets that could help transform beneficial exercise effects into a pill.

Assessment Committee

Associate Professor Lasse Gliemann (chair), Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.

Professor Anna Krook, Karolinska, Stockholm.

Professor Hadi Al-Hasani, German Diabetes Center, Düsseldorf.

Supervisors

Professor Jørgen Frank Pind Wojtaszewski, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.

Associate Professor Rasmus Kjøbsted, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.

Place

Building: HCØ, Room: Aud 6, Universitetsparken 5, 2100 Copenhagen.

Copy of thesis

Email address to gain access to the thesis: ljp559@alumni.ku.dk.

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