PhD defence: Novel molecular players in metabolic adaptations to exercise (NOMINEE)
Tang Cam Phung Pham
PhD thesis
The decline in muscle function during aging and obesity can be counteracted by exercise training. Our understanding of the adaptive responses in skeletal muscle to exercise training has advanced due to various omic approaches; yet the functional consequences of many players involved in these processes are not defined.
In the present PhD study, I aimed to uncover the role of two new potential regulators of training-mediated health benefits: SRA stem-loop interacting RNA-binding protein (SLIRP) and Traf2- and Nck interacting protein kinase (TNIK).
In addition, mechanisms of actions of SLIRP and TNIK in skeletal muscle biology and the adaptive response to ET were evaluated separately.
This PhD project provides novel insights into the complexity of adaptive responses of skeletal muscle and non-skeletal-muscle tissues, including liver and adipose tissue in response to ET and/or diet.
My findings underline exercise training as a frontline strategy against mitochondrial and metabolism-associated diseases and further suggest TNIK as potential pharmacological target to inspire the conception of new therapeutic strategies against metabolism-associated diseases in obesity.
Download: Table of contents; Abstract; Resumé; Publication list.
2022, 152 pages.
Time
7 October 2022, 14:00
Place
Aud. 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen
Opponents
Associate professor Anke Ninija Karabanov (chair), Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
Associate professor Carles Alvarez Cantó, Senior Specialist in Metabolic Sensing, Nestlé Institute of Health Sciences, Switzerland.
Professor Marcus Krueger, University of Köln, Germany.
Supervisor
Associate professor Lykke Sylow, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
Co-supervisor
Professor Erik Richter, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
The thesis is available for inspection at Nørre Allé 51, DK-2200 Copenhagen N.