Whole-blood PUFA and associations with markers of nutritional and health status in acutely malnourished children in Cambodia
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Whole-blood PUFA and associations with markers of nutritional and health status in acutely malnourished children in Cambodia. / Sigh, Sanne; Lauritzen, Lotte; Wieringa, Frank T; Laillou, Arnaud; Chamnan, Chhoun; Angkeabos, Nheb; Moniboth, Duch; Berger, Jacques; Stark, Ken D; Roos, Nanna.
I: Public Health Nutrition, Bind 23, Nr. 6, 2020, s. 974-986.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Whole-blood PUFA and associations with markers of nutritional and health status in acutely malnourished children in Cambodia
AU - Sigh, Sanne
AU - Lauritzen, Lotte
AU - Wieringa, Frank T
AU - Laillou, Arnaud
AU - Chamnan, Chhoun
AU - Angkeabos, Nheb
AU - Moniboth, Duch
AU - Berger, Jacques
AU - Stark, Ken D
AU - Roos, Nanna
N1 - CURIS 2020 NEXS 070 (Embargo)
PY - 2020
Y1 - 2020
N2 - Objective: To measure fatty acid composition, particularly whole-blood PUFA content, in acutely malnourished children and identify associations with markers of nutritional and health status.Design: PUFA were assessed in dried blood spots obtained from a cross-sectional study. Nutritional and health status were assessed by anthropometry, haemoglobinopathies, inflammation and blood counts.Setting: Cambodia.Participants: The study was conducted with 174 children aged 0·5-18 years with acute malnutrition. Results: Among total fatty acids (FA), the relative percentage of total PUFA was 20 % FA, with 14 % of the children having very low PUFA (mead acid (MA):arachidonic acid (AA) >0·02, n-6 docosapentaenoic acid:DHA >0·2 and total n-6:n-3 PUFA >10·5). Wasting was not associated with any PUFA. Stunting and low height were consistently positively associated with total PUFA and positively with n-6 PUFA. Height was positively associated with n-3 long-chain PUFA (LCPUFA). The presence of haemoglobinopathies or inflammation was positively associated with MA:AA, but not total PUFA. Elevated blood platelet counts were positively correlated with linoleic acid and appeared to be influenced by anaemia (P = 0·010) and inflammation (P = 0·002). Monocyte counts were high during inflammation (P = 0·052) and correlated positively with n-6 LCPUFA and n-3 LCPUFA. Conclusions: Children with acute malnutrition or stunting had low PUFA, while elevated platelets and monocytes were associated with high PUFA. In acutely malnourished children, inflammation could lead to elevated blood cell counts resulting in increased whole-blood PUFA which does not reflect dietary intake or nutritional status.
AB - Objective: To measure fatty acid composition, particularly whole-blood PUFA content, in acutely malnourished children and identify associations with markers of nutritional and health status.Design: PUFA were assessed in dried blood spots obtained from a cross-sectional study. Nutritional and health status were assessed by anthropometry, haemoglobinopathies, inflammation and blood counts.Setting: Cambodia.Participants: The study was conducted with 174 children aged 0·5-18 years with acute malnutrition. Results: Among total fatty acids (FA), the relative percentage of total PUFA was 20 % FA, with 14 % of the children having very low PUFA (mead acid (MA):arachidonic acid (AA) >0·02, n-6 docosapentaenoic acid:DHA >0·2 and total n-6:n-3 PUFA >10·5). Wasting was not associated with any PUFA. Stunting and low height were consistently positively associated with total PUFA and positively with n-6 PUFA. Height was positively associated with n-3 long-chain PUFA (LCPUFA). The presence of haemoglobinopathies or inflammation was positively associated with MA:AA, but not total PUFA. Elevated blood platelet counts were positively correlated with linoleic acid and appeared to be influenced by anaemia (P = 0·010) and inflammation (P = 0·002). Monocyte counts were high during inflammation (P = 0·052) and correlated positively with n-6 LCPUFA and n-3 LCPUFA. Conclusions: Children with acute malnutrition or stunting had low PUFA, while elevated platelets and monocytes were associated with high PUFA. In acutely malnourished children, inflammation could lead to elevated blood cell counts resulting in increased whole-blood PUFA which does not reflect dietary intake or nutritional status.
KW - Acutely malnourished children
KW - Blood cell counts
KW - Inflammation
KW - Nutritional status
KW - PUFA
U2 - 10.1017/S1368980019003744
DO - 10.1017/S1368980019003744
M3 - Journal article
C2 - 31973779
AN - SCOPUS:85078476953
VL - 23
SP - 974
EP - 986
JO - Public Health Nutrition
JF - Public Health Nutrition
SN - 1368-9800
IS - 6
ER -
ID: 235966159