TY - JOUR

T1 - Prevention of taste alterations in patients with cancer receiving Paclitaxel- or Oxaliplatin-based chemotherapy — A pilot trial of cannabidiol

AU - Dominiak, Helena Sylow Heilmann

AU - Hasselsteen, Simone Dyring

AU - Nielsen, Sebastian Werngren

AU - Andersen, Jens Rikardt

AU - Herrstedt, Jørn

N1 - Publisher Copyright: © 2023 by the authors.

PY - 2023

Y1 - 2023

N2 - Introduction: Taste alteration is a common adverse effect of chemotherapy. This study aimed to investigate the effect of cannabidiol (CBD) on Lean Body Mass (LBM), and taste alterations during oxaliplatin- or paclitaxel-based chemotherapy. Methods: LBM was estimated by bioelectrical impedance analysis (BIA), and taste perception was evaluated by a randomized sensory test of six samples: sweet, salt, and umami, all in weak and strong concentrations. Taste perceptions were scored on visual analog scales. Patients in the intervention group received oral CBD 300 mg/day for 8 days; patients in the control group did not. Patients were followed for three cycles of chemotherapy. Results: Twenty-two/ten patients (intervention/control group) were eligible. No effects on LBM were demonstrated. At baseline, the control group was able to differentiate between weak and strong saltiness and weak and strong sweetness but lost this ability after three cycles of chemotherapy. At baseline, the intervention group was unable to differentiate between the concentrations but gained the ability to significantly differentiate between weak and strong sweetness (p = 0.03) and weak and strong saltiness (p = 0.04) after three cycles of chemotherapy and treatment with CBD. Conclusions: CBD may improve patients’ ability to differentiate taste strengths during chemotherapy.

AB - Introduction: Taste alteration is a common adverse effect of chemotherapy. This study aimed to investigate the effect of cannabidiol (CBD) on Lean Body Mass (LBM), and taste alterations during oxaliplatin- or paclitaxel-based chemotherapy. Methods: LBM was estimated by bioelectrical impedance analysis (BIA), and taste perception was evaluated by a randomized sensory test of six samples: sweet, salt, and umami, all in weak and strong concentrations. Taste perceptions were scored on visual analog scales. Patients in the intervention group received oral CBD 300 mg/day for 8 days; patients in the control group did not. Patients were followed for three cycles of chemotherapy. Results: Twenty-two/ten patients (intervention/control group) were eligible. No effects on LBM were demonstrated. At baseline, the control group was able to differentiate between weak and strong saltiness and weak and strong sweetness but lost this ability after three cycles of chemotherapy. At baseline, the intervention group was unable to differentiate between the concentrations but gained the ability to significantly differentiate between weak and strong sweetness (p = 0.03) and weak and strong saltiness (p = 0.04) after three cycles of chemotherapy and treatment with CBD. Conclusions: CBD may improve patients’ ability to differentiate taste strengths during chemotherapy.

KW - Cancer

KW - Cannabidiol

KW - Cannabis

KW - CBD

KW - Chemotherapy

KW - Chemotherapy-induced taste alterations

KW - Sensory test

KW - Taste

U2 - 10.3390/nu15133014

DO - 10.3390/nu15133014

M3 - Journal article

C2 - 37447339

AN - SCOPUS:85164670152

VL - 15

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 13

M1 - 3014

ER -