Sodium nitroprusside dilates cerebral vessels and enhances internal carotid artery flow in young men
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Sodium nitroprusside dilates cerebral vessels and enhances internal carotid artery flow in young men. / Olesen, Niels Damkjær; Fischer, Mads; Secher, Niels H.
I: Journal of Physiology, Bind 596, Nr. 17, 2018, s. 3967-3976.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Sodium nitroprusside dilates cerebral vessels and enhances internal carotid artery flow in young men
AU - Olesen, Niels Damkjær
AU - Fischer, Mads
AU - Secher, Niels H.
N1 - CURIS 2018 NEXS 296
PY - 2018
Y1 - 2018
N2 - Cerebral autoregulation maintains cerebral blood flow (CBF) despite marked changes in mean arterial pressure (MAP). Sodium nitroprusside (SNP) reduces blood pressure by vasodilatation but is reported to lower CBF, probably by a reduction in its perfusion pressure. We evaluated the influence of SNP on CBF and aimed for a 20% and then 40% reduction in MAP, while keeping MAP ≥ 50 mmHg, to challenge cerebral autoregulation. In 19 healthy men (age 24 ± 4 years; mean ± SD) duplex ultrasound determined right internal carotid (ICA) and vertebral artery (VA) blood flow. The SNP reduced MAP (from 83 ± 8 to 69 ± 8 and 58 ± 4 mmHg; both P < 0.0001), total peripheral resistance, and arterial CO2 tension (P aCO2; 41 ± 3 vs. 39 ± 3 and 37 ± 4 mmHg; both P < 0.01). Yet ICA flow increased with the moderate reduction in MAP but returned to the baseline value with the large reduction in MAP (336 ± 66 vs. 365 ± 69; P = 0.013 and 349 ± 82 ml min-1; n.s.), while VA flow (114 ± 34 vs. 112 ± 38 and 110 ± 42 ml min-1; both n.s.) and CBF ((ICA + VA flow) × 2; 899 ± 135 vs. 962 ± 127 and 918 ± 197 ml min-1; both n.s.) were maintained with increased cerebrovascular conductance. In conclusion, CBF is maintained during SNP-induced reduction in MAP despite reduced P aC O2 and the results indicate that SNP dilates cerebral vessels and increases ICA flow. Journal compilation
AB - Cerebral autoregulation maintains cerebral blood flow (CBF) despite marked changes in mean arterial pressure (MAP). Sodium nitroprusside (SNP) reduces blood pressure by vasodilatation but is reported to lower CBF, probably by a reduction in its perfusion pressure. We evaluated the influence of SNP on CBF and aimed for a 20% and then 40% reduction in MAP, while keeping MAP ≥ 50 mmHg, to challenge cerebral autoregulation. In 19 healthy men (age 24 ± 4 years; mean ± SD) duplex ultrasound determined right internal carotid (ICA) and vertebral artery (VA) blood flow. The SNP reduced MAP (from 83 ± 8 to 69 ± 8 and 58 ± 4 mmHg; both P < 0.0001), total peripheral resistance, and arterial CO2 tension (P aCO2; 41 ± 3 vs. 39 ± 3 and 37 ± 4 mmHg; both P < 0.01). Yet ICA flow increased with the moderate reduction in MAP but returned to the baseline value with the large reduction in MAP (336 ± 66 vs. 365 ± 69; P = 0.013 and 349 ± 82 ml min-1; n.s.), while VA flow (114 ± 34 vs. 112 ± 38 and 110 ± 42 ml min-1; both n.s.) and CBF ((ICA + VA flow) × 2; 899 ± 135 vs. 962 ± 127 and 918 ± 197 ml min-1; both n.s.) were maintained with increased cerebrovascular conductance. In conclusion, CBF is maintained during SNP-induced reduction in MAP despite reduced P aC O2 and the results indicate that SNP dilates cerebral vessels and increases ICA flow. Journal compilation
KW - Cerebral blood flow
KW - Doppler ultrasound
KW - Hypotension
KW - Sodium nitroprusside
U2 - 10.1113/JP275887
DO - 10.1113/JP275887
M3 - Journal article
C2 - 29917239
AN - SCOPUS:85050548503
VL - 596
SP - 3967
EP - 3976
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - 17
ER -
ID: 201227006