Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies: the PREVIEW project

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Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies : the PREVIEW project. / Sluik, Diewertje; Brouwer-Brolsma, Elske M; Berendsen, Agnes A M; Mikkilä, Vera; Poppitt, Sally D; Silvestre, Marta P; Tremblay, Angelo; Pérusse, Louis; Bouchard, Claude; Raben, Anne; Feskens, Edith J M.

I: American Journal of Clinical Nutrition, Bind 109, Nr. 5, 2019, s. 1310-1318.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Sluik, D, Brouwer-Brolsma, EM, Berendsen, AAM, Mikkilä, V, Poppitt, SD, Silvestre, MP, Tremblay, A, Pérusse, L, Bouchard, C, Raben, A & Feskens, EJM 2019, 'Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies: the PREVIEW project', American Journal of Clinical Nutrition, bind 109, nr. 5, s. 1310-1318. https://doi.org/10.1093/ajcn/nqy388, https://doi.org/10.1093/ajcn/nqz221

APA

Sluik, D., Brouwer-Brolsma, E. M., Berendsen, A. A. M., Mikkilä, V., Poppitt, S. D., Silvestre, M. P., ... Feskens, E. J. M. (2019). Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies: the PREVIEW project. American Journal of Clinical Nutrition, 109(5), 1310-1318. https://doi.org/10.1093/ajcn/nqy388, https://doi.org/10.1093/ajcn/nqz221

Vancouver

Sluik D, Brouwer-Brolsma EM, Berendsen AAM, Mikkilä V, Poppitt SD, Silvestre MP o.a. Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies: the PREVIEW project. American Journal of Clinical Nutrition. 2019;109(5):1310-1318. https://doi.org/10.1093/ajcn/nqy388, https://doi.org/10.1093/ajcn/nqz221

Author

Sluik, Diewertje ; Brouwer-Brolsma, Elske M ; Berendsen, Agnes A M ; Mikkilä, Vera ; Poppitt, Sally D ; Silvestre, Marta P ; Tremblay, Angelo ; Pérusse, Louis ; Bouchard, Claude ; Raben, Anne ; Feskens, Edith J M. / Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies : the PREVIEW project. I: American Journal of Clinical Nutrition. 2019 ; Bind 109, Nr. 5. s. 1310-1318.

Bibtex

@article{ee88fb4ac08341a39b40ec53b86c0acc,
title = "Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies: the PREVIEW project",
abstract = "Background: Data on the relationship between protein intake and the risk of type 2 diabetes are conflicting.Objective: We studied prospective associations between the intake of total, plant-based, and animal protein and the risk of pre-diabetes and diabetes in 4 population-based studies included in the PREVIEW project.Methods: Analyses were conducted with the use of data from 3 European cohorts and 1 Canadian cohort, including 78,851 participants. Protein intake was assessed through the use of harmonized data from food-frequency questionnaires or 3-d dietary records. Cohort-specific incidence ratios (IRs) were estimated for pre-diabetes and diabetes, adjusting for general characteristics, lifestyle and dietary factors, disease history, and body mass index (BMI) and waist circumference; results were pooled based on a random-effects meta-analysis.Results: Higher total protein intake (g · kg-1 · d-1) was associated with lower incidences of pre-diabetes and diabetes (pooled IRs: 0.84; 95{\%} CI: 0.82, 0.87 and 0.49; 95{\%} CI: 0.28, 0.83, respectively); plant-based protein intake was the main determinant (pooled IRs: 0.83; 95{\%} CI: 0.81, 0.86 and 0.53; 95{\%} CI: 0.36, 0.76, respectively). Substituting 2 energy percentage (E{\%}) protein at the expense of carbohydrates revealed increased risks of pre-diabetes and diabetes (pooled IRs: 1.04; 95{\%} CI: 1.01, 1.07 and 1.09; 95{\%} CI: 1.01, 1.18, respectively). Except for the associations between intakes of total protein and plant-based protein (g · kg-1 · d-1) and diabetes, all other associations became nonsignificant after adjustment for BMI and waist circumference.Conclusions: Higher protein intake (g · kg-1 · d-1) was associated with a lower risk of pre-diabetes and diabetes. Associations were substantially attenuated after adjustments for BMI and waist circumference, which demonstrates a crucial role for adiposity and may account for previous conflicting findings. This study was registered at ISRCTN as ISRCTN31174892.",
keywords = "Faculty of Science, Diabetes, Impaired glucose metabolism, Protein intake, Observational studies, Epidemiology",
author = "Diewertje Sluik and Brouwer-Brolsma, {Elske M} and Berendsen, {Agnes A M} and Vera Mikkil{\"a} and Poppitt, {Sally D} and Silvestre, {Marta P} and Angelo Tremblay and Louis P{\'e}russe and Claude Bouchard and Anne Raben and Feskens, {Edith J M}",
note = "CURIS 2019 NEXS 154 Copyright {\circledC} American Society for Nutrition 2019.",
year = "2019",
doi = "10.1093/ajcn/nqy388",
language = "English",
volume = "109",
pages = "1310--1318",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "5",

}

RIS

TY - JOUR

T1 - Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies

T2 - the PREVIEW project

AU - Sluik, Diewertje

AU - Brouwer-Brolsma, Elske M

AU - Berendsen, Agnes A M

AU - Mikkilä, Vera

AU - Poppitt, Sally D

AU - Silvestre, Marta P

AU - Tremblay, Angelo

AU - Pérusse, Louis

AU - Bouchard, Claude

AU - Raben, Anne

AU - Feskens, Edith J M

N1 - CURIS 2019 NEXS 154 Copyright © American Society for Nutrition 2019.

PY - 2019

Y1 - 2019

N2 - Background: Data on the relationship between protein intake and the risk of type 2 diabetes are conflicting.Objective: We studied prospective associations between the intake of total, plant-based, and animal protein and the risk of pre-diabetes and diabetes in 4 population-based studies included in the PREVIEW project.Methods: Analyses were conducted with the use of data from 3 European cohorts and 1 Canadian cohort, including 78,851 participants. Protein intake was assessed through the use of harmonized data from food-frequency questionnaires or 3-d dietary records. Cohort-specific incidence ratios (IRs) were estimated for pre-diabetes and diabetes, adjusting for general characteristics, lifestyle and dietary factors, disease history, and body mass index (BMI) and waist circumference; results were pooled based on a random-effects meta-analysis.Results: Higher total protein intake (g · kg-1 · d-1) was associated with lower incidences of pre-diabetes and diabetes (pooled IRs: 0.84; 95% CI: 0.82, 0.87 and 0.49; 95% CI: 0.28, 0.83, respectively); plant-based protein intake was the main determinant (pooled IRs: 0.83; 95% CI: 0.81, 0.86 and 0.53; 95% CI: 0.36, 0.76, respectively). Substituting 2 energy percentage (E%) protein at the expense of carbohydrates revealed increased risks of pre-diabetes and diabetes (pooled IRs: 1.04; 95% CI: 1.01, 1.07 and 1.09; 95% CI: 1.01, 1.18, respectively). Except for the associations between intakes of total protein and plant-based protein (g · kg-1 · d-1) and diabetes, all other associations became nonsignificant after adjustment for BMI and waist circumference.Conclusions: Higher protein intake (g · kg-1 · d-1) was associated with a lower risk of pre-diabetes and diabetes. Associations were substantially attenuated after adjustments for BMI and waist circumference, which demonstrates a crucial role for adiposity and may account for previous conflicting findings. This study was registered at ISRCTN as ISRCTN31174892.

AB - Background: Data on the relationship between protein intake and the risk of type 2 diabetes are conflicting.Objective: We studied prospective associations between the intake of total, plant-based, and animal protein and the risk of pre-diabetes and diabetes in 4 population-based studies included in the PREVIEW project.Methods: Analyses were conducted with the use of data from 3 European cohorts and 1 Canadian cohort, including 78,851 participants. Protein intake was assessed through the use of harmonized data from food-frequency questionnaires or 3-d dietary records. Cohort-specific incidence ratios (IRs) were estimated for pre-diabetes and diabetes, adjusting for general characteristics, lifestyle and dietary factors, disease history, and body mass index (BMI) and waist circumference; results were pooled based on a random-effects meta-analysis.Results: Higher total protein intake (g · kg-1 · d-1) was associated with lower incidences of pre-diabetes and diabetes (pooled IRs: 0.84; 95% CI: 0.82, 0.87 and 0.49; 95% CI: 0.28, 0.83, respectively); plant-based protein intake was the main determinant (pooled IRs: 0.83; 95% CI: 0.81, 0.86 and 0.53; 95% CI: 0.36, 0.76, respectively). Substituting 2 energy percentage (E%) protein at the expense of carbohydrates revealed increased risks of pre-diabetes and diabetes (pooled IRs: 1.04; 95% CI: 1.01, 1.07 and 1.09; 95% CI: 1.01, 1.18, respectively). Except for the associations between intakes of total protein and plant-based protein (g · kg-1 · d-1) and diabetes, all other associations became nonsignificant after adjustment for BMI and waist circumference.Conclusions: Higher protein intake (g · kg-1 · d-1) was associated with a lower risk of pre-diabetes and diabetes. Associations were substantially attenuated after adjustments for BMI and waist circumference, which demonstrates a crucial role for adiposity and may account for previous conflicting findings. This study was registered at ISRCTN as ISRCTN31174892.

KW - Faculty of Science

KW - Diabetes

KW - Impaired glucose metabolism

KW - Protein intake

KW - Observational studies

KW - Epidemiology

U2 - 10.1093/ajcn/nqy388

DO - 10.1093/ajcn/nqy388

M3 - Journal article

C2 - 31051510

VL - 109

SP - 1310

EP - 1318

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -

ID: 217550727