Multinutrient supplementation increases collagen synthesis during early wound repair in a randomized controlled trial in patients with inguinal hernia

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Standard

Multinutrient supplementation increases collagen synthesis during early wound repair in a randomized controlled trial in patients with inguinal hernia. / Kjaer, Marie; Frederiksen, Amalie Kruse Sigersted; Nissen, Neel Ingemann; Willumsen, Nicholas; van Hall, Gerrit; Jørgensen, Lars Nannestad; Andersen, Jens Rikardt; Ågren, Magnus S.

I: Journal of Nutrition, Bind 150, Nr. 4, 2020, s. 792-799.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Kjaer, M, Frederiksen, AKS, Nissen, NI, Willumsen, N, van Hall, G, Jørgensen, LN, Andersen, JR & Ågren, MS 2020, 'Multinutrient supplementation increases collagen synthesis during early wound repair in a randomized controlled trial in patients with inguinal hernia', Journal of Nutrition, bind 150, nr. 4, s. 792-799. https://doi.org/10.1093/jn/nxz324

APA

Kjaer, M., Frederiksen, A. K. S., Nissen, N. I., Willumsen, N., van Hall, G., Jørgensen, L. N., ... Ågren, M. S. (2020). Multinutrient supplementation increases collagen synthesis during early wound repair in a randomized controlled trial in patients with inguinal hernia. Journal of Nutrition, 150(4), 792-799. https://doi.org/10.1093/jn/nxz324

Vancouver

Kjaer M, Frederiksen AKS, Nissen NI, Willumsen N, van Hall G, Jørgensen LN o.a. Multinutrient supplementation increases collagen synthesis during early wound repair in a randomized controlled trial in patients with inguinal hernia. Journal of Nutrition. 2020;150(4):792-799. https://doi.org/10.1093/jn/nxz324

Author

Kjaer, Marie ; Frederiksen, Amalie Kruse Sigersted ; Nissen, Neel Ingemann ; Willumsen, Nicholas ; van Hall, Gerrit ; Jørgensen, Lars Nannestad ; Andersen, Jens Rikardt ; Ågren, Magnus S. / Multinutrient supplementation increases collagen synthesis during early wound repair in a randomized controlled trial in patients with inguinal hernia. I: Journal of Nutrition. 2020 ; Bind 150, Nr. 4. s. 792-799.

Bibtex

@article{32758f68afb14ce9a7596c6eeaae1e84,
title = "Multinutrient supplementation increases collagen synthesis during early wound repair in a randomized controlled trial in patients with inguinal hernia",
abstract = "Background: Inguinal hernia disease is associated with an imbalanced collagen metabolism. Surgical stress has a negative impact on nutrients important for collagen synthesis.Objective: We hypothesized that supplementation with a combination of nutrients would enhance collagen biosynthesis in inguinal hernia disease patients when undergoing hernia repair.Methods: In this exploratory randomized controlled trial, 21 men (age: 55.2 ± 2.8 y; BMI: 25.0 ± 0.7 kg/m2) scheduled for Lichtenstein inguinal hernia repair were assigned to multinutrient supplementation (n = 10; multinutrient group) or no multinutrient supplementation (n = 11; control group). The multinutrient group received 14 g l-arginine, 14 g l-glutamine, 1250 mg vitamin C, and 55 mg zinc daily starting 14 d before surgery and ending 14 d after surgery. The multinutrient and control groups received high-quality protein to ensure a daily intake of 1.5 g protein/kg. Collagen biosynthesis was measured by the biomarkers type I procollagen propeptide (CICP), type III procollagen propeptide (PRO-C3), and type V procollagen propeptide (PRO-C5) in the sera on days -14, 0, and 1, and in the wound fluids on postoperative days 1 and 2. Compliance was recorded after the 28-d intervention period.Results: Serum PRO-C5 concentrations decreased (P < 0.05) postoperatively in the control but not the multinutrient group. Neither CICP nor PRO-C3 serum concentrations differed significantly between the 2 groups. In wound fluid, the CICP concentrations increased (P < 0.05) from days 1 to 2 in the multinutrient group and were 49{\%} higher (P = 0.10) than those in the control group on day 2. Wound fluid concentrations PRO-C3 and PRO-C5 showed no significant time or group differences. The 28-d compliance was similar (P = 0.27) in the 2 groups.Conclusion: Oral supplementation with arginine, glutamine, vitamin C, and zinc augment collagen synthesis during the first 2 d after inguinal hernia repair. This trial was registered at clinicaltrials.gov as NCT03221686.",
keywords = "Faculty of Science, Collagen synthesis, Wound healing, Surgery, Biomarkers, Zink, Ascorbic acid, Amino acids",
author = "Marie Kjaer and Frederiksen, {Amalie Kruse Sigersted} and Nissen, {Neel Ingemann} and Nicholas Willumsen and {van Hall}, Gerrit and J{\o}rgensen, {Lars Nannestad} and Andersen, {Jens Rikardt} and {\AA}gren, {Magnus S}",
note = "Copyright {\circledC} The Author(s) 2020.",
year = "2020",
doi = "10.1093/jn/nxz324",
language = "English",
volume = "150",
pages = "792--799",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "4",

}

RIS

TY - JOUR

T1 - Multinutrient supplementation increases collagen synthesis during early wound repair in a randomized controlled trial in patients with inguinal hernia

AU - Kjaer, Marie

AU - Frederiksen, Amalie Kruse Sigersted

AU - Nissen, Neel Ingemann

AU - Willumsen, Nicholas

AU - van Hall, Gerrit

AU - Jørgensen, Lars Nannestad

AU - Andersen, Jens Rikardt

AU - Ågren, Magnus S

N1 - Copyright © The Author(s) 2020.

PY - 2020

Y1 - 2020

N2 - Background: Inguinal hernia disease is associated with an imbalanced collagen metabolism. Surgical stress has a negative impact on nutrients important for collagen synthesis.Objective: We hypothesized that supplementation with a combination of nutrients would enhance collagen biosynthesis in inguinal hernia disease patients when undergoing hernia repair.Methods: In this exploratory randomized controlled trial, 21 men (age: 55.2 ± 2.8 y; BMI: 25.0 ± 0.7 kg/m2) scheduled for Lichtenstein inguinal hernia repair were assigned to multinutrient supplementation (n = 10; multinutrient group) or no multinutrient supplementation (n = 11; control group). The multinutrient group received 14 g l-arginine, 14 g l-glutamine, 1250 mg vitamin C, and 55 mg zinc daily starting 14 d before surgery and ending 14 d after surgery. The multinutrient and control groups received high-quality protein to ensure a daily intake of 1.5 g protein/kg. Collagen biosynthesis was measured by the biomarkers type I procollagen propeptide (CICP), type III procollagen propeptide (PRO-C3), and type V procollagen propeptide (PRO-C5) in the sera on days -14, 0, and 1, and in the wound fluids on postoperative days 1 and 2. Compliance was recorded after the 28-d intervention period.Results: Serum PRO-C5 concentrations decreased (P < 0.05) postoperatively in the control but not the multinutrient group. Neither CICP nor PRO-C3 serum concentrations differed significantly between the 2 groups. In wound fluid, the CICP concentrations increased (P < 0.05) from days 1 to 2 in the multinutrient group and were 49% higher (P = 0.10) than those in the control group on day 2. Wound fluid concentrations PRO-C3 and PRO-C5 showed no significant time or group differences. The 28-d compliance was similar (P = 0.27) in the 2 groups.Conclusion: Oral supplementation with arginine, glutamine, vitamin C, and zinc augment collagen synthesis during the first 2 d after inguinal hernia repair. This trial was registered at clinicaltrials.gov as NCT03221686.

AB - Background: Inguinal hernia disease is associated with an imbalanced collagen metabolism. Surgical stress has a negative impact on nutrients important for collagen synthesis.Objective: We hypothesized that supplementation with a combination of nutrients would enhance collagen biosynthesis in inguinal hernia disease patients when undergoing hernia repair.Methods: In this exploratory randomized controlled trial, 21 men (age: 55.2 ± 2.8 y; BMI: 25.0 ± 0.7 kg/m2) scheduled for Lichtenstein inguinal hernia repair were assigned to multinutrient supplementation (n = 10; multinutrient group) or no multinutrient supplementation (n = 11; control group). The multinutrient group received 14 g l-arginine, 14 g l-glutamine, 1250 mg vitamin C, and 55 mg zinc daily starting 14 d before surgery and ending 14 d after surgery. The multinutrient and control groups received high-quality protein to ensure a daily intake of 1.5 g protein/kg. Collagen biosynthesis was measured by the biomarkers type I procollagen propeptide (CICP), type III procollagen propeptide (PRO-C3), and type V procollagen propeptide (PRO-C5) in the sera on days -14, 0, and 1, and in the wound fluids on postoperative days 1 and 2. Compliance was recorded after the 28-d intervention period.Results: Serum PRO-C5 concentrations decreased (P < 0.05) postoperatively in the control but not the multinutrient group. Neither CICP nor PRO-C3 serum concentrations differed significantly between the 2 groups. In wound fluid, the CICP concentrations increased (P < 0.05) from days 1 to 2 in the multinutrient group and were 49% higher (P = 0.10) than those in the control group on day 2. Wound fluid concentrations PRO-C3 and PRO-C5 showed no significant time or group differences. The 28-d compliance was similar (P = 0.27) in the 2 groups.Conclusion: Oral supplementation with arginine, glutamine, vitamin C, and zinc augment collagen synthesis during the first 2 d after inguinal hernia repair. This trial was registered at clinicaltrials.gov as NCT03221686.

KW - Faculty of Science

KW - Collagen synthesis

KW - Wound healing

KW - Surgery

KW - Biomarkers

KW - Zink

KW - Ascorbic acid

KW - Amino acids

U2 - 10.1093/jn/nxz324

DO - 10.1093/jn/nxz324

M3 - Journal article

C2 - 31897483

VL - 150

SP - 792

EP - 799

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 4

ER -

ID: 237653335