Ionophores in the Environment

Publikation: KonferencebidragPosterForskning

  • Søren Alex Bak
  • Martin Hansen
  • Erland Björklund
  • Bent Halling-Sørensen
Questions have arisen about the effects of veterinary medicines and especially their metabolites have on organisms in the environment. A couple of recent investigations has further reported that metabolites of certain veterinary drugs such as antibacterial agents (i.e. tetracyclines) and antiparacitics (i.e. ionophores) posses an environmental effects of similar level as their parent compounds on i.e. the soil bacterial community (Halling-Sørensen et al.2002; Hansen et al. 2009). Ionophores are used extensively worldwide as prophylactic chemotherapeutics and growth promoters in livestock production. Ionophores are antibiotic drugs that form lipid soluble complexes with, primarily, alkali cations that inhibit or kill pathogenic parasites in livestock. Several reports have revealed that ionophores are emerging environmental contaminants in agricultural run-off waters, surface waters, sediments, and ground waters, due to their continuously increased and constant application as feed additives in modern livestock production.
This presentation will focus on the development of new analytical method for determination of ionophores in liquid and solid matrices. The hyphenated method consist of pressurised liquid extraction with integrated clean-up followed by solid phase extraction and high-performance liquid chromatography tandem in space mass spectrometry (PLE-SPE-LC-MS/MS).

Halling-Sørensen B, Sengelov G, Tjornelund J (2002) Arch Environ Contam Toxicol, 42: 3, p. 263-271.
DOI: 10.1007/s00244-001-0017-2
Hansen M, Krogh KA, Brandt A, Christensen JH, Halling-Sorensen B (2009) Environmental Pollution 157: 2 p. 474-480. DOI:10.1016/j.envpol.2008.09.022
Publikationsdato24 maj 2010
StatusUdgivet - 24 maj 2010
BegivenhedSETAC Europe 20th annual meeting - Sevilla, Spanien
Varighed: 23 maj 201027 maj 2010


KonferenceSETAC Europe 20th annual meeting

ID: 35085717