Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

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Standard

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise. / Catoire, Milène; Alex, Sheril; Paraskevopulos, Nicolas; Mattijssen, Frits; Evers-van Gogh, Inkie; Schaart, Gert; Jeppesen, Jacob Fuglsbjerg; Kneppers, Anita; Mensink, Marco; Voshol, Peter J; Olivecrona, Gunilla; Tan, Nguan Soon; Hesselink, Matthijs K C; Berbée, Jimmy F; Rensen, Patrick C N; Kalkhoven, Eric; Schrauwen, Patrick; Kersten, Sander.

I: Proceedings of the National Academy of Sciences of the United States of America, Bind 111, Nr. 11, 2014, s. E1043-E1052.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Catoire, M, Alex, S, Paraskevopulos, N, Mattijssen, F, Evers-van Gogh, I, Schaart, G, Jeppesen, JF, Kneppers, A, Mensink, M, Voshol, PJ, Olivecrona, G, Tan, NS, Hesselink, MKC, Berbée, JF, Rensen, PCN, Kalkhoven, E, Schrauwen, P & Kersten, S 2014, 'Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise', Proceedings of the National Academy of Sciences of the United States of America, bind 111, nr. 11, s. E1043-E1052. https://doi.org/10.1073/pnas.1400889111

APA

Catoire, M., Alex, S., Paraskevopulos, N., Mattijssen, F., Evers-van Gogh, I., Schaart, G., Jeppesen, J. F., Kneppers, A., Mensink, M., Voshol, P. J., Olivecrona, G., Tan, N. S., Hesselink, M. K. C., Berbée, J. F., Rensen, P. C. N., Kalkhoven, E., Schrauwen, P., & Kersten, S. (2014). Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise. Proceedings of the National Academy of Sciences of the United States of America, 111(11), E1043-E1052. https://doi.org/10.1073/pnas.1400889111

Vancouver

Catoire M, Alex S, Paraskevopulos N, Mattijssen F, Evers-van Gogh I, Schaart G o.a. Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(11):E1043-E1052. https://doi.org/10.1073/pnas.1400889111

Author

Catoire, Milène ; Alex, Sheril ; Paraskevopulos, Nicolas ; Mattijssen, Frits ; Evers-van Gogh, Inkie ; Schaart, Gert ; Jeppesen, Jacob Fuglsbjerg ; Kneppers, Anita ; Mensink, Marco ; Voshol, Peter J ; Olivecrona, Gunilla ; Tan, Nguan Soon ; Hesselink, Matthijs K C ; Berbée, Jimmy F ; Rensen, Patrick C N ; Kalkhoven, Eric ; Schrauwen, Patrick ; Kersten, Sander. / Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise. I: Proceedings of the National Academy of Sciences of the United States of America. 2014 ; Bind 111, Nr. 11. s. E1043-E1052.

Bibtex

@article{9e8beb27cbd64d8d96c8b8dd39ebd71a,
title = "Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise",
abstract = "Physical activity increases energy metabolism in exercising muscle. Whether acute exercise elicits metabolic changes in nonexercising muscles remains unclear. We show that one of the few genes that is more highly induced in nonexercising muscle than in exercising human muscle during acute exercise encodes angiopoietin-like 4 (ANGPTL4), an inhibitor of lipoprotein lipase-mediated plasma triglyceride clearance. Using a combination of human, animal, and in vitro data, we show that induction of ANGPTL4 in nonexercising muscle is mediated by elevated plasma free fatty acids via peroxisome proliferator-activated receptor-δ, presumably leading to reduced local uptake of plasma triglyceride-derived fatty acids and their sparing for use by exercising muscle. In contrast, the induction of ANGPTL4 in exercising muscle likely is counteracted via AMP-activated protein kinase (AMPK)-mediated down-regulation, promoting the use of plasma triglycerides as fuel for active muscles. Our data suggest that nonexercising muscle and the local regulation of ANGPTL4 via AMPK and free fatty acids have key roles in governing lipid homeostasis during exercise.",
keywords = "Adult, Angiopoietins, Exercise, Fatty Acids, Fluorescent Antibody Technique, Homeostasis, Humans, Lipid Metabolism, Male, Microarray Analysis, Middle Aged, Muscle, Skeletal",
author = "Mil{\`e}ne Catoire and Sheril Alex and Nicolas Paraskevopulos and Frits Mattijssen and {Evers-van Gogh}, Inkie and Gert Schaart and Jeppesen, {Jacob Fuglsbjerg} and Anita Kneppers and Marco Mensink and Voshol, {Peter J} and Gunilla Olivecrona and Tan, {Nguan Soon} and Hesselink, {Matthijs K C} and Berb{\'e}e, {Jimmy F} and Rensen, {Patrick C N} and Eric Kalkhoven and Patrick Schrauwen and Sander Kersten",
note = "CURIS 2014 NEXS 364",
year = "2014",
doi = "10.1073/pnas.1400889111",
language = "English",
volume = "111",
pages = "E1043--E1052",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "11",

}

RIS

TY - JOUR

T1 - Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

AU - Catoire, Milène

AU - Alex, Sheril

AU - Paraskevopulos, Nicolas

AU - Mattijssen, Frits

AU - Evers-van Gogh, Inkie

AU - Schaart, Gert

AU - Jeppesen, Jacob Fuglsbjerg

AU - Kneppers, Anita

AU - Mensink, Marco

AU - Voshol, Peter J

AU - Olivecrona, Gunilla

AU - Tan, Nguan Soon

AU - Hesselink, Matthijs K C

AU - Berbée, Jimmy F

AU - Rensen, Patrick C N

AU - Kalkhoven, Eric

AU - Schrauwen, Patrick

AU - Kersten, Sander

N1 - CURIS 2014 NEXS 364

PY - 2014

Y1 - 2014

N2 - Physical activity increases energy metabolism in exercising muscle. Whether acute exercise elicits metabolic changes in nonexercising muscles remains unclear. We show that one of the few genes that is more highly induced in nonexercising muscle than in exercising human muscle during acute exercise encodes angiopoietin-like 4 (ANGPTL4), an inhibitor of lipoprotein lipase-mediated plasma triglyceride clearance. Using a combination of human, animal, and in vitro data, we show that induction of ANGPTL4 in nonexercising muscle is mediated by elevated plasma free fatty acids via peroxisome proliferator-activated receptor-δ, presumably leading to reduced local uptake of plasma triglyceride-derived fatty acids and their sparing for use by exercising muscle. In contrast, the induction of ANGPTL4 in exercising muscle likely is counteracted via AMP-activated protein kinase (AMPK)-mediated down-regulation, promoting the use of plasma triglycerides as fuel for active muscles. Our data suggest that nonexercising muscle and the local regulation of ANGPTL4 via AMPK and free fatty acids have key roles in governing lipid homeostasis during exercise.

AB - Physical activity increases energy metabolism in exercising muscle. Whether acute exercise elicits metabolic changes in nonexercising muscles remains unclear. We show that one of the few genes that is more highly induced in nonexercising muscle than in exercising human muscle during acute exercise encodes angiopoietin-like 4 (ANGPTL4), an inhibitor of lipoprotein lipase-mediated plasma triglyceride clearance. Using a combination of human, animal, and in vitro data, we show that induction of ANGPTL4 in nonexercising muscle is mediated by elevated plasma free fatty acids via peroxisome proliferator-activated receptor-δ, presumably leading to reduced local uptake of plasma triglyceride-derived fatty acids and their sparing for use by exercising muscle. In contrast, the induction of ANGPTL4 in exercising muscle likely is counteracted via AMP-activated protein kinase (AMPK)-mediated down-regulation, promoting the use of plasma triglycerides as fuel for active muscles. Our data suggest that nonexercising muscle and the local regulation of ANGPTL4 via AMPK and free fatty acids have key roles in governing lipid homeostasis during exercise.

KW - Adult

KW - Angiopoietins

KW - Exercise

KW - Fatty Acids

KW - Fluorescent Antibody Technique

KW - Homeostasis

KW - Humans

KW - Lipid Metabolism

KW - Male

KW - Microarray Analysis

KW - Middle Aged

KW - Muscle, Skeletal

U2 - 10.1073/pnas.1400889111

DO - 10.1073/pnas.1400889111

M3 - Journal article

C2 - 24591600

VL - 111

SP - E1043-E1052

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 11

ER -

ID: 128655902