Effects of oily fish intake on cognitive and socioemotional function in healthy 8-9-year-old children: the FiSK Junior randomized trial

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Effects of oily fish intake on cognitive and socioemotional function in healthy 8-9-year-old children : the FiSK Junior randomized trial. / Teisen, Marie Nygaard; Vuholm, Stine; Niclasen, Janni; Aristizabal-Henao, Juan J; Stark, Ken D; Geertsen, Svend Sparre; Damsgaard, Camilla Trab; Lauritzen, Lotte.

I: American Journal of Clinical Nutrition, Bind 112, Nr. 1, 2020, s. 74-83.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Teisen, MN, Vuholm, S, Niclasen, J, Aristizabal-Henao, JJ, Stark, KD, Geertsen, SS, Damsgaard, CT & Lauritzen, L 2020, 'Effects of oily fish intake on cognitive and socioemotional function in healthy 8-9-year-old children: the FiSK Junior randomized trial', American Journal of Clinical Nutrition, bind 112, nr. 1, s. 74-83. https://doi.org/10.1093/ajcn/nqaa050

APA

Teisen, M. N., Vuholm, S., Niclasen, J., Aristizabal-Henao, J. J., Stark, K. D., Geertsen, S. S., ... Lauritzen, L. (2020). Effects of oily fish intake on cognitive and socioemotional function in healthy 8-9-year-old children: the FiSK Junior randomized trial. American Journal of Clinical Nutrition, 112(1), 74-83. https://doi.org/10.1093/ajcn/nqaa050

Vancouver

Teisen MN, Vuholm S, Niclasen J, Aristizabal-Henao JJ, Stark KD, Geertsen SS o.a. Effects of oily fish intake on cognitive and socioemotional function in healthy 8-9-year-old children: the FiSK Junior randomized trial. American Journal of Clinical Nutrition. 2020;112(1):74-83. https://doi.org/10.1093/ajcn/nqaa050

Author

Teisen, Marie Nygaard ; Vuholm, Stine ; Niclasen, Janni ; Aristizabal-Henao, Juan J ; Stark, Ken D ; Geertsen, Svend Sparre ; Damsgaard, Camilla Trab ; Lauritzen, Lotte. / Effects of oily fish intake on cognitive and socioemotional function in healthy 8-9-year-old children : the FiSK Junior randomized trial. I: American Journal of Clinical Nutrition. 2020 ; Bind 112, Nr. 1. s. 74-83.

Bibtex

@article{31bfaed1e87a4e71a9d14a74844eef5d,
title = "Effects of oily fish intake on cognitive and socioemotional function in healthy 8-9-year-old children: the FiSK Junior randomized trial",
abstract = "Background: Long-chain n-3 PUFAs (n-3 LCPUFAs) accrete in the brain during childhood and affect brain development. Randomized trials in children show inconsistent effects of n-3 LCPUFAs on cognitive and socioemotional function, and few have investigated effects of fish per se.Objectives: We aimed to investigate the effects of oily fish consumption on overall and domain-specific cognitive and socioemotional scores and explore sex differences.Methods: Healthy 8-9-y-old children (n = 199) were randomly allocated to receive ∼300 g/wk oily fish or poultry (control) for 12 ± 2 wk. At baseline and endpoint, we assessed attention, processing speed, executive functions, memory, emotions, and behavior with a large battery of tests and questionnaires and analyzed erythrocyte fatty acid composition.Results: One hundred and ninety-seven (99{\%}) children completed the trial. Children in the fish group consumed 375 (25th-75th percentile: 325-426) g/wk oily fish resulting in 2.3 (95{\%} CI: 1.9, 2.6) fatty acid percentage points higher erythrocyte n-3 LCPUFA than in the poultry group. The overall cognitive performance score tended to improve by 0.17 (95{\%} CI: -0.01, 0.35) points in children who received fish compared with poultry, supported by n-3 LCPUFA dose dependency. This was driven mainly by fewer errors [-1.9 (95{\%} CI: -3.4, -0.3)] in an attention task and improved cognitive flexibility measured as faster reaction time [-51 ms (95{\%} CI: -94, -7 ms)] in a complex relative to a simple task ({"}mixing cost{"}). The fish intervention furthermore reduced parent-rated Strength and Difficulties Questionnaire total difficulties by -0.89 (95{\%} CI: -1.60, -0.18) points mainly due to a -0.63 (95{\%} CI: -1.11, -0.16) points reduction in internalizing problems that was reflected in tendency to a decrease in the overall socioemotional problems score of -0.13 (95{\%} CI: -0.26, 0.01) points. The overall effects were similar in boys and girls.Conclusions: Oily fish dose-dependently improved cognitive function, especially attention and cognitive flexibility, and reduced socioemotional problems. The results support the importance of n-3 LCPUFAs for optimal brain function and fish intake recommendations in children.The trial was registered at www.clinicaltrials.gov as NCT02809508.",
keywords = "Faculty of Science, Omega-3, Docosahexaenoic acid (22:6n-3, DHA), Eicosapentaenoic acid (20:5n-3, EPA), Cognitive performance, Externalizing problems, Internalizing problems, Prosocial behavior, Boys, Girls",
author = "Teisen, {Marie Nygaard} and Stine Vuholm and Janni Niclasen and Aristizabal-Henao, {Juan J} and Stark, {Ken D} and Geertsen, {Svend Sparre} and Damsgaard, {Camilla Trab} and Lotte Lauritzen",
note = "Copyright {\circledC} The Author(s) on behalf of the American Society for Nutrition 2020.",
year = "2020",
doi = "10.1093/ajcn/nqaa050",
language = "English",
volume = "112",
pages = "74--83",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "1",

}

RIS

TY - JOUR

T1 - Effects of oily fish intake on cognitive and socioemotional function in healthy 8-9-year-old children

T2 - the FiSK Junior randomized trial

AU - Teisen, Marie Nygaard

AU - Vuholm, Stine

AU - Niclasen, Janni

AU - Aristizabal-Henao, Juan J

AU - Stark, Ken D

AU - Geertsen, Svend Sparre

AU - Damsgaard, Camilla Trab

AU - Lauritzen, Lotte

N1 - Copyright © The Author(s) on behalf of the American Society for Nutrition 2020.

PY - 2020

Y1 - 2020

N2 - Background: Long-chain n-3 PUFAs (n-3 LCPUFAs) accrete in the brain during childhood and affect brain development. Randomized trials in children show inconsistent effects of n-3 LCPUFAs on cognitive and socioemotional function, and few have investigated effects of fish per se.Objectives: We aimed to investigate the effects of oily fish consumption on overall and domain-specific cognitive and socioemotional scores and explore sex differences.Methods: Healthy 8-9-y-old children (n = 199) were randomly allocated to receive ∼300 g/wk oily fish or poultry (control) for 12 ± 2 wk. At baseline and endpoint, we assessed attention, processing speed, executive functions, memory, emotions, and behavior with a large battery of tests and questionnaires and analyzed erythrocyte fatty acid composition.Results: One hundred and ninety-seven (99%) children completed the trial. Children in the fish group consumed 375 (25th-75th percentile: 325-426) g/wk oily fish resulting in 2.3 (95% CI: 1.9, 2.6) fatty acid percentage points higher erythrocyte n-3 LCPUFA than in the poultry group. The overall cognitive performance score tended to improve by 0.17 (95% CI: -0.01, 0.35) points in children who received fish compared with poultry, supported by n-3 LCPUFA dose dependency. This was driven mainly by fewer errors [-1.9 (95% CI: -3.4, -0.3)] in an attention task and improved cognitive flexibility measured as faster reaction time [-51 ms (95% CI: -94, -7 ms)] in a complex relative to a simple task ("mixing cost"). The fish intervention furthermore reduced parent-rated Strength and Difficulties Questionnaire total difficulties by -0.89 (95% CI: -1.60, -0.18) points mainly due to a -0.63 (95% CI: -1.11, -0.16) points reduction in internalizing problems that was reflected in tendency to a decrease in the overall socioemotional problems score of -0.13 (95% CI: -0.26, 0.01) points. The overall effects were similar in boys and girls.Conclusions: Oily fish dose-dependently improved cognitive function, especially attention and cognitive flexibility, and reduced socioemotional problems. The results support the importance of n-3 LCPUFAs for optimal brain function and fish intake recommendations in children.The trial was registered at www.clinicaltrials.gov as NCT02809508.

AB - Background: Long-chain n-3 PUFAs (n-3 LCPUFAs) accrete in the brain during childhood and affect brain development. Randomized trials in children show inconsistent effects of n-3 LCPUFAs on cognitive and socioemotional function, and few have investigated effects of fish per se.Objectives: We aimed to investigate the effects of oily fish consumption on overall and domain-specific cognitive and socioemotional scores and explore sex differences.Methods: Healthy 8-9-y-old children (n = 199) were randomly allocated to receive ∼300 g/wk oily fish or poultry (control) for 12 ± 2 wk. At baseline and endpoint, we assessed attention, processing speed, executive functions, memory, emotions, and behavior with a large battery of tests and questionnaires and analyzed erythrocyte fatty acid composition.Results: One hundred and ninety-seven (99%) children completed the trial. Children in the fish group consumed 375 (25th-75th percentile: 325-426) g/wk oily fish resulting in 2.3 (95% CI: 1.9, 2.6) fatty acid percentage points higher erythrocyte n-3 LCPUFA than in the poultry group. The overall cognitive performance score tended to improve by 0.17 (95% CI: -0.01, 0.35) points in children who received fish compared with poultry, supported by n-3 LCPUFA dose dependency. This was driven mainly by fewer errors [-1.9 (95% CI: -3.4, -0.3)] in an attention task and improved cognitive flexibility measured as faster reaction time [-51 ms (95% CI: -94, -7 ms)] in a complex relative to a simple task ("mixing cost"). The fish intervention furthermore reduced parent-rated Strength and Difficulties Questionnaire total difficulties by -0.89 (95% CI: -1.60, -0.18) points mainly due to a -0.63 (95% CI: -1.11, -0.16) points reduction in internalizing problems that was reflected in tendency to a decrease in the overall socioemotional problems score of -0.13 (95% CI: -0.26, 0.01) points. The overall effects were similar in boys and girls.Conclusions: Oily fish dose-dependently improved cognitive function, especially attention and cognitive flexibility, and reduced socioemotional problems. The results support the importance of n-3 LCPUFAs for optimal brain function and fish intake recommendations in children.The trial was registered at www.clinicaltrials.gov as NCT02809508.

KW - Faculty of Science

KW - Omega-3

KW - Docosahexaenoic acid (22:6n-3, DHA)

KW - Eicosapentaenoic acid (20:5n-3, EPA)

KW - Cognitive performance

KW - Externalizing problems

KW - Internalizing problems

KW - Prosocial behavior

KW - Boys

KW - Girls

U2 - 10.1093/ajcn/nqaa050

DO - 10.1093/ajcn/nqaa050

M3 - Journal article

C2 - 32529206

VL - 112

SP - 74

EP - 83

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 1

ER -

ID: 243014702