Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake

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Standard

Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake. / De Bock, K; Derave, W; Eijnde, B O; Hesselink, M K; Koninckx, E; Rose, Adam John; Schrauwen, P; Bonen, A; Richter, Erik A.; Hespel, P.

I: Journal of Applied Physiology, Bind 104, Nr. 4, 2008, s. 1045-1055.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

De Bock, K, Derave, W, Eijnde, BO, Hesselink, MK, Koninckx, E, Rose, AJ, Schrauwen, P, Bonen, A, Richter, EA & Hespel, P 2008, 'Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake', Journal of Applied Physiology, bind 104, nr. 4, s. 1045-1055. https://doi.org/10.1152/japplphysiol.01195.2007

APA

De Bock, K., Derave, W., Eijnde, B. O., Hesselink, M. K., Koninckx, E., Rose, A. J., ... Hespel, P. (2008). Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake. Journal of Applied Physiology, 104(4), 1045-1055. https://doi.org/10.1152/japplphysiol.01195.2007

Vancouver

De Bock K, Derave W, Eijnde BO, Hesselink MK, Koninckx E, Rose AJ o.a. Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake. Journal of Applied Physiology. 2008;104(4):1045-1055. https://doi.org/10.1152/japplphysiol.01195.2007

Author

De Bock, K ; Derave, W ; Eijnde, B O ; Hesselink, M K ; Koninckx, E ; Rose, Adam John ; Schrauwen, P ; Bonen, A ; Richter, Erik A. ; Hespel, P. / Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake. I: Journal of Applied Physiology. 2008 ; Bind 104, Nr. 4. s. 1045-1055.

Bibtex

@article{f34ffb10070c11ddbee902004c4f4f50,
title = "Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake",
abstract = "Skeletal muscle gene response to exercise depends on nutritional status during and after exercise, but it is unknown whether muscle adaptations to endurance training are affected by nutritional status during training sessions. Therefore, this study investigated the effect of an endurance training program (6 wk, 3 day/wk, 1-2 h, 75{\%} of peak Vo(2)) in moderately active males. They trained in the fasted (F; n = 10) or carbohydrate-fed state (CHO; n = 10) while receiving a standardized diet [65 percent of total energy intake (En) from carbohydrates, 20{\%}En fat, 15{\%}En protein]. Before and after the training period, substrate use during a 2-h exercise bout was determined. During these experimental sessions, all subjects were in a fed condition and received extra carbohydrates (1 g.kg body wt(-1) .h(-1)). Peak Vo(2) (+7{\%}), succinate dehydrogenase activity, GLUT4, and hexokinase II content were similarly increased between F and CHO. Fatty acid binding protein (FABPm) content increased significantly in F (P = 0.007). Intramyocellular triglyceride content (IMCL) remained unchanged in both groups. After training, pre-exercise glycogen content was higher in CHO (545 +/- 19 mmol/kg dry wt; P = 0.02), but not in F (434 +/- 32 mmol/kg dry wt; P = 0.23). For a given initial glycogen content, F blunted exercise-induced glycogen breakdown when compared with CHO (P = 0.04). Neither IMCL breakdown (P = 0.23) nor fat oxidation rates during exercise were altered by training. Thus short-term training elicits similar adaptations in peak Vo(2) whether carried out in the fasted or carbohydrate-fed state. Although there was a decrease in exercise-induced glycogen breakdown and an increase in proteins involved in fat handling after fasting training, fat oxidation during exercise with carbohydrate intake was not changed.",
author = "{De Bock}, K and W Derave and Eijnde, {B O} and Hesselink, {M K} and E Koninckx and Rose, {Adam John} and P Schrauwen and A Bonen and Richter, {Erik A.} and P Hespel",
note = "CURIS 2008 5200 34",
year = "2008",
doi = "10.1152/japplphysiol.01195.2007",
language = "English",
volume = "104",
pages = "1045--1055",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "4",

}

RIS

TY - JOUR

T1 - Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake

AU - De Bock, K

AU - Derave, W

AU - Eijnde, B O

AU - Hesselink, M K

AU - Koninckx, E

AU - Rose, Adam John

AU - Schrauwen, P

AU - Bonen, A

AU - Richter, Erik A.

AU - Hespel, P

N1 - CURIS 2008 5200 34

PY - 2008

Y1 - 2008

N2 - Skeletal muscle gene response to exercise depends on nutritional status during and after exercise, but it is unknown whether muscle adaptations to endurance training are affected by nutritional status during training sessions. Therefore, this study investigated the effect of an endurance training program (6 wk, 3 day/wk, 1-2 h, 75% of peak Vo(2)) in moderately active males. They trained in the fasted (F; n = 10) or carbohydrate-fed state (CHO; n = 10) while receiving a standardized diet [65 percent of total energy intake (En) from carbohydrates, 20%En fat, 15%En protein]. Before and after the training period, substrate use during a 2-h exercise bout was determined. During these experimental sessions, all subjects were in a fed condition and received extra carbohydrates (1 g.kg body wt(-1) .h(-1)). Peak Vo(2) (+7%), succinate dehydrogenase activity, GLUT4, and hexokinase II content were similarly increased between F and CHO. Fatty acid binding protein (FABPm) content increased significantly in F (P = 0.007). Intramyocellular triglyceride content (IMCL) remained unchanged in both groups. After training, pre-exercise glycogen content was higher in CHO (545 +/- 19 mmol/kg dry wt; P = 0.02), but not in F (434 +/- 32 mmol/kg dry wt; P = 0.23). For a given initial glycogen content, F blunted exercise-induced glycogen breakdown when compared with CHO (P = 0.04). Neither IMCL breakdown (P = 0.23) nor fat oxidation rates during exercise were altered by training. Thus short-term training elicits similar adaptations in peak Vo(2) whether carried out in the fasted or carbohydrate-fed state. Although there was a decrease in exercise-induced glycogen breakdown and an increase in proteins involved in fat handling after fasting training, fat oxidation during exercise with carbohydrate intake was not changed.

AB - Skeletal muscle gene response to exercise depends on nutritional status during and after exercise, but it is unknown whether muscle adaptations to endurance training are affected by nutritional status during training sessions. Therefore, this study investigated the effect of an endurance training program (6 wk, 3 day/wk, 1-2 h, 75% of peak Vo(2)) in moderately active males. They trained in the fasted (F; n = 10) or carbohydrate-fed state (CHO; n = 10) while receiving a standardized diet [65 percent of total energy intake (En) from carbohydrates, 20%En fat, 15%En protein]. Before and after the training period, substrate use during a 2-h exercise bout was determined. During these experimental sessions, all subjects were in a fed condition and received extra carbohydrates (1 g.kg body wt(-1) .h(-1)). Peak Vo(2) (+7%), succinate dehydrogenase activity, GLUT4, and hexokinase II content were similarly increased between F and CHO. Fatty acid binding protein (FABPm) content increased significantly in F (P = 0.007). Intramyocellular triglyceride content (IMCL) remained unchanged in both groups. After training, pre-exercise glycogen content was higher in CHO (545 +/- 19 mmol/kg dry wt; P = 0.02), but not in F (434 +/- 32 mmol/kg dry wt; P = 0.23). For a given initial glycogen content, F blunted exercise-induced glycogen breakdown when compared with CHO (P = 0.04). Neither IMCL breakdown (P = 0.23) nor fat oxidation rates during exercise were altered by training. Thus short-term training elicits similar adaptations in peak Vo(2) whether carried out in the fasted or carbohydrate-fed state. Although there was a decrease in exercise-induced glycogen breakdown and an increase in proteins involved in fat handling after fasting training, fat oxidation during exercise with carbohydrate intake was not changed.

U2 - 10.1152/japplphysiol.01195.2007

DO - 10.1152/japplphysiol.01195.2007

M3 - Journal article

C2 - 18276898

VL - 104

SP - 1045

EP - 1055

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 4

ER -

ID: 3592485