Effect of high versus low carbohydrate intake in the morning on glycemic variability and glycemic control measured by continuous blood glucose monitoring in women with gestational diabetes mellitus - A randomized crossover study

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Effect of high versus low carbohydrate intake in the morning on glycemic variability and glycemic control measured by continuous blood glucose monitoring in women with gestational diabetes mellitus - A randomized crossover study. / Rasmussen, Louise; Christensen, Maria Lund; Poulsen, Charlotte Wolff; Rud, Charlotte; Christensen, Alexander Sidelmann; Andersen, Jens Rikardt; Kampmann, Ulla; Ovesen, Per Glud.

I: Nutrients, Bind 12, Nr. 2, 475, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Rasmussen, L, Christensen, ML, Poulsen, CW, Rud, C, Christensen, AS, Andersen, JR, Kampmann, U & Ovesen, PG 2020, 'Effect of high versus low carbohydrate intake in the morning on glycemic variability and glycemic control measured by continuous blood glucose monitoring in women with gestational diabetes mellitus - A randomized crossover study', Nutrients, bind 12, nr. 2, 475. https://doi.org/10.3390/nu12020475

APA

Rasmussen, L., Christensen, M. L., Poulsen, C. W., Rud, C., Christensen, A. S., Andersen, J. R., ... Ovesen, P. G. (2020). Effect of high versus low carbohydrate intake in the morning on glycemic variability and glycemic control measured by continuous blood glucose monitoring in women with gestational diabetes mellitus - A randomized crossover study. Nutrients, 12(2), [475]. https://doi.org/10.3390/nu12020475

Vancouver

Rasmussen L, Christensen ML, Poulsen CW, Rud C, Christensen AS, Andersen JR o.a. Effect of high versus low carbohydrate intake in the morning on glycemic variability and glycemic control measured by continuous blood glucose monitoring in women with gestational diabetes mellitus - A randomized crossover study. Nutrients. 2020;12(2). 475. https://doi.org/10.3390/nu12020475

Author

Rasmussen, Louise ; Christensen, Maria Lund ; Poulsen, Charlotte Wolff ; Rud, Charlotte ; Christensen, Alexander Sidelmann ; Andersen, Jens Rikardt ; Kampmann, Ulla ; Ovesen, Per Glud. / Effect of high versus low carbohydrate intake in the morning on glycemic variability and glycemic control measured by continuous blood glucose monitoring in women with gestational diabetes mellitus - A randomized crossover study. I: Nutrients. 2020 ; Bind 12, Nr. 2.

Bibtex

@article{f2cb8830394c4da39bf458f776f207ec,
title = "Effect of high versus low carbohydrate intake in the morning on glycemic variability and glycemic control measured by continuous blood glucose monitoring in women with gestational diabetes mellitus - A randomized crossover study",
abstract = "Carbohydrate is the macronutrient that has the greatest impact on blood glucose response. Limited data are available on how carbohydrate distribution throughout the day affects blood glucose in women with gestational diabetes mellitus (GDM). We aimed to assess how a high-carbohydrate morning-intake (HCM) versus a low-carbohydrate-morning-intake (LCM), affect glycemic variability and glucose control. In this randomized crossover study continuous glucose monitoring (CGM) was performed in 12 women with diet treated GDM (75 g, 2-h OGTT ≥ 8.5 mmol/L), who went through 2 × 3 days of HCM and LCM. A within-subject-analysis showed a significantly higher mean amplitude of glucose excursions (MAGE) (0.7 mmol/L, p = 0.004) and coefficient of variation (CV) (5.1{\%}, p = 0.01) when comparing HCM with LCM, whereas a significantly lower mean glucose (MG) (-0.3 mmol/L, p = 0.002) and fasting blood glucose (FBG) were found (-0.4 mmol/L, p = 0.01) on the HCM diet compared to the LCM diet. In addition, insulin resistance, expressed as Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), decreased significantly during HCM. Results indicate that a carbohydrate distribution of 50{\%} in the morning favors lower blood glucose and improvement in insulin sensitivity in women with GDM, but in contrary gives a higher glycemic variability.",
keywords = "Faculty of Science, Glycemic variability, Carbohydrate distribution, Gestational diabetes mellitus, Mean amplitude of glucose, Breakfast diet",
author = "Louise Rasmussen and Christensen, {Maria Lund} and Poulsen, {Charlotte Wolff} and Charlotte Rud and Christensen, {Alexander Sidelmann} and Andersen, {Jens Rikardt} and Ulla Kampmann and Ovesen, {Per Glud}",
note = "CURIS 2020 NEXS 035",
year = "2020",
doi = "10.3390/nu12020475",
language = "English",
volume = "12",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "2",

}

RIS

TY - JOUR

T1 - Effect of high versus low carbohydrate intake in the morning on glycemic variability and glycemic control measured by continuous blood glucose monitoring in women with gestational diabetes mellitus - A randomized crossover study

AU - Rasmussen, Louise

AU - Christensen, Maria Lund

AU - Poulsen, Charlotte Wolff

AU - Rud, Charlotte

AU - Christensen, Alexander Sidelmann

AU - Andersen, Jens Rikardt

AU - Kampmann, Ulla

AU - Ovesen, Per Glud

N1 - CURIS 2020 NEXS 035

PY - 2020

Y1 - 2020

N2 - Carbohydrate is the macronutrient that has the greatest impact on blood glucose response. Limited data are available on how carbohydrate distribution throughout the day affects blood glucose in women with gestational diabetes mellitus (GDM). We aimed to assess how a high-carbohydrate morning-intake (HCM) versus a low-carbohydrate-morning-intake (LCM), affect glycemic variability and glucose control. In this randomized crossover study continuous glucose monitoring (CGM) was performed in 12 women with diet treated GDM (75 g, 2-h OGTT ≥ 8.5 mmol/L), who went through 2 × 3 days of HCM and LCM. A within-subject-analysis showed a significantly higher mean amplitude of glucose excursions (MAGE) (0.7 mmol/L, p = 0.004) and coefficient of variation (CV) (5.1%, p = 0.01) when comparing HCM with LCM, whereas a significantly lower mean glucose (MG) (-0.3 mmol/L, p = 0.002) and fasting blood glucose (FBG) were found (-0.4 mmol/L, p = 0.01) on the HCM diet compared to the LCM diet. In addition, insulin resistance, expressed as Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), decreased significantly during HCM. Results indicate that a carbohydrate distribution of 50% in the morning favors lower blood glucose and improvement in insulin sensitivity in women with GDM, but in contrary gives a higher glycemic variability.

AB - Carbohydrate is the macronutrient that has the greatest impact on blood glucose response. Limited data are available on how carbohydrate distribution throughout the day affects blood glucose in women with gestational diabetes mellitus (GDM). We aimed to assess how a high-carbohydrate morning-intake (HCM) versus a low-carbohydrate-morning-intake (LCM), affect glycemic variability and glucose control. In this randomized crossover study continuous glucose monitoring (CGM) was performed in 12 women with diet treated GDM (75 g, 2-h OGTT ≥ 8.5 mmol/L), who went through 2 × 3 days of HCM and LCM. A within-subject-analysis showed a significantly higher mean amplitude of glucose excursions (MAGE) (0.7 mmol/L, p = 0.004) and coefficient of variation (CV) (5.1%, p = 0.01) when comparing HCM with LCM, whereas a significantly lower mean glucose (MG) (-0.3 mmol/L, p = 0.002) and fasting blood glucose (FBG) were found (-0.4 mmol/L, p = 0.01) on the HCM diet compared to the LCM diet. In addition, insulin resistance, expressed as Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), decreased significantly during HCM. Results indicate that a carbohydrate distribution of 50% in the morning favors lower blood glucose and improvement in insulin sensitivity in women with GDM, but in contrary gives a higher glycemic variability.

KW - Faculty of Science

KW - Glycemic variability

KW - Carbohydrate distribution

KW - Gestational diabetes mellitus

KW - Mean amplitude of glucose

KW - Breakfast diet

U2 - 10.3390/nu12020475

DO - 10.3390/nu12020475

M3 - Journal article

C2 - 32069857

VL - 12

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 2

M1 - 475

ER -

ID: 237656340