Content of n-3 LC-PUFA in breast milk four months postpartum is associated with infancy blood pressure in boys and infancy blood lipid profile in girls

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Content of n-3 LC-PUFA in breast milk four months postpartum is associated with infancy blood pressure in boys and infancy blood lipid profile in girls. / Bruun, Signe; van Rossem, Lenie; Lauritzen, Lotte; Husby, Steffen; Neergaard Jacobsen, Lotte; Michaelsen, Kim F.; Boysen Sandberg, Maria; Stark, Ken D; Sørensen, Jan; Zachariassen, Gitte.

I: Nutrients, Bind 11, Nr. 2, 235, 28.01.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bruun, S, van Rossem, L, Lauritzen, L, Husby, S, Neergaard Jacobsen, L, Michaelsen, KF, Boysen Sandberg, M, Stark, KD, Sørensen, J & Zachariassen, G 2019, 'Content of n-3 LC-PUFA in breast milk four months postpartum is associated with infancy blood pressure in boys and infancy blood lipid profile in girls', Nutrients, bind 11, nr. 2, 235. https://doi.org/10.3390/nu11020235

APA

Bruun, S., van Rossem, L., Lauritzen, L., Husby, S., Neergaard Jacobsen, L., Michaelsen, K. F., ... Zachariassen, G. (2019). Content of n-3 LC-PUFA in breast milk four months postpartum is associated with infancy blood pressure in boys and infancy blood lipid profile in girls. Nutrients, 11(2), [235]. https://doi.org/10.3390/nu11020235

Vancouver

Bruun S, van Rossem L, Lauritzen L, Husby S, Neergaard Jacobsen L, Michaelsen KF o.a. Content of n-3 LC-PUFA in breast milk four months postpartum is associated with infancy blood pressure in boys and infancy blood lipid profile in girls. Nutrients. 2019 jan 28;11(2). 235. https://doi.org/10.3390/nu11020235

Author

Bruun, Signe ; van Rossem, Lenie ; Lauritzen, Lotte ; Husby, Steffen ; Neergaard Jacobsen, Lotte ; Michaelsen, Kim F. ; Boysen Sandberg, Maria ; Stark, Ken D ; Sørensen, Jan ; Zachariassen, Gitte. / Content of n-3 LC-PUFA in breast milk four months postpartum is associated with infancy blood pressure in boys and infancy blood lipid profile in girls. I: Nutrients. 2019 ; Bind 11, Nr. 2.

Bibtex

@article{b2e4d88eee2d4d04b7333b2be2c86aef,
title = "Content of n-3 LC-PUFA in breast milk four months postpartum is associated with infancy blood pressure in boys and infancy blood lipid profile in girls",
abstract = "Blood pressure (BP) and blood lipid profile (BLP) have been shown to track from childhood into adulthood, and n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) in breast milk have been suggested as mediators of the beneficial long-term effect of breastfeeding on BP and BLP. We aimed to investigate associations between n-3 LC-PUFA content in breast milk at 4 months postpartum and offspring BP and BLP in early life. BP and BLP were measured at 4, 18, and 36 months. Statistical analyses were sex-stratified and adjusted for gestational age, maternal pre-pregnancy body mass index (BMI), and maternal educational level. Based on 336 mother-child dyads, high n-3 LC-PUFA in breast milk was inversely associated with systolic and diastolic BP in boys at 4 months (β = -20.0 (95{\%} CI = -33.4, -6.7), p = 0.004 and β = -10.2 (95{\%} CI = -19.8, -0.5), p = 0.039, respectively); inversely associated with HDL cholesterol, and directly associated with triglyceride in girls at 4 months (β = -0.7 (95{\%} CI = -1.1, -0.3), p = 0.001 and β = 3.1 (95{\%} CI = 1.0, 5.2), p = 0.005, respectively). Associations observed at the later time points were non-significant. Furthermore, we observed sex-specific changes over time in both size and direction of the associations. Our results indicate that early intake of n-3 LC-PUFA can affect early development in cardiometabolic factors such as BP and BLP in a sex-specific manner. Follow-up and further investigation in later childhood is planned.",
keywords = "Faculty of Science, Cohort study, Cardiovascular health, Omega-3, Fatty acids, Human milk, Milk composition, Cholesterol, Triglyceride",
author = "Signe Bruun and {van Rossem}, Lenie and Lotte Lauritzen and Steffen Husby and {Neergaard Jacobsen}, Lotte and Michaelsen, {Kim F.} and {Boysen Sandberg}, Maria and Stark, {Ken D} and Jan S{\o}rensen and Gitte Zachariassen",
note = "CURIS 2019 NEXS 037",
year = "2019",
month = "1",
day = "28",
doi = "10.3390/nu11020235",
language = "English",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "2",

}

RIS

TY - JOUR

T1 - Content of n-3 LC-PUFA in breast milk four months postpartum is associated with infancy blood pressure in boys and infancy blood lipid profile in girls

AU - Bruun, Signe

AU - van Rossem, Lenie

AU - Lauritzen, Lotte

AU - Husby, Steffen

AU - Neergaard Jacobsen, Lotte

AU - Michaelsen, Kim F.

AU - Boysen Sandberg, Maria

AU - Stark, Ken D

AU - Sørensen, Jan

AU - Zachariassen, Gitte

N1 - CURIS 2019 NEXS 037

PY - 2019/1/28

Y1 - 2019/1/28

N2 - Blood pressure (BP) and blood lipid profile (BLP) have been shown to track from childhood into adulthood, and n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) in breast milk have been suggested as mediators of the beneficial long-term effect of breastfeeding on BP and BLP. We aimed to investigate associations between n-3 LC-PUFA content in breast milk at 4 months postpartum and offspring BP and BLP in early life. BP and BLP were measured at 4, 18, and 36 months. Statistical analyses were sex-stratified and adjusted for gestational age, maternal pre-pregnancy body mass index (BMI), and maternal educational level. Based on 336 mother-child dyads, high n-3 LC-PUFA in breast milk was inversely associated with systolic and diastolic BP in boys at 4 months (β = -20.0 (95% CI = -33.4, -6.7), p = 0.004 and β = -10.2 (95% CI = -19.8, -0.5), p = 0.039, respectively); inversely associated with HDL cholesterol, and directly associated with triglyceride in girls at 4 months (β = -0.7 (95% CI = -1.1, -0.3), p = 0.001 and β = 3.1 (95% CI = 1.0, 5.2), p = 0.005, respectively). Associations observed at the later time points were non-significant. Furthermore, we observed sex-specific changes over time in both size and direction of the associations. Our results indicate that early intake of n-3 LC-PUFA can affect early development in cardiometabolic factors such as BP and BLP in a sex-specific manner. Follow-up and further investigation in later childhood is planned.

AB - Blood pressure (BP) and blood lipid profile (BLP) have been shown to track from childhood into adulthood, and n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) in breast milk have been suggested as mediators of the beneficial long-term effect of breastfeeding on BP and BLP. We aimed to investigate associations between n-3 LC-PUFA content in breast milk at 4 months postpartum and offspring BP and BLP in early life. BP and BLP were measured at 4, 18, and 36 months. Statistical analyses were sex-stratified and adjusted for gestational age, maternal pre-pregnancy body mass index (BMI), and maternal educational level. Based on 336 mother-child dyads, high n-3 LC-PUFA in breast milk was inversely associated with systolic and diastolic BP in boys at 4 months (β = -20.0 (95% CI = -33.4, -6.7), p = 0.004 and β = -10.2 (95% CI = -19.8, -0.5), p = 0.039, respectively); inversely associated with HDL cholesterol, and directly associated with triglyceride in girls at 4 months (β = -0.7 (95% CI = -1.1, -0.3), p = 0.001 and β = 3.1 (95% CI = 1.0, 5.2), p = 0.005, respectively). Associations observed at the later time points were non-significant. Furthermore, we observed sex-specific changes over time in both size and direction of the associations. Our results indicate that early intake of n-3 LC-PUFA can affect early development in cardiometabolic factors such as BP and BLP in a sex-specific manner. Follow-up and further investigation in later childhood is planned.

KW - Faculty of Science

KW - Cohort study

KW - Cardiovascular health

KW - Omega-3

KW - Fatty acids

KW - Human milk

KW - Milk composition

KW - Cholesterol

KW - Triglyceride

U2 - 10.3390/nu11020235

DO - 10.3390/nu11020235

M3 - Journal article

C2 - 30678226

VL - 11

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 2

M1 - 235

ER -

ID: 212905107