Body composition during outpatient treatment of severe acute malnutrition: Results from a randomised trial testing different doses of ready-to-use therapeutic foods

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Body composition during outpatient treatment of severe acute malnutrition : Results from a randomised trial testing different doses of ready-to-use therapeutic foods. / Kangas, Suvi T; Kæstel, Pernille; Salpéteur, Cécile; Nikièma, Victor; Talley, Leisel; Briend, André; Ritz, Christian; Friis, Henrik; Wells, Jonathan C.

I: Clinical Nutrition, 06.03.2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Kangas, ST, Kæstel, P, Salpéteur, C, Nikièma, V, Talley, L, Briend, A, Ritz, C, Friis, H & Wells, JC 2020, 'Body composition during outpatient treatment of severe acute malnutrition: Results from a randomised trial testing different doses of ready-to-use therapeutic foods', Clinical Nutrition. https://doi.org/10.1016/j.clnu.2020.02.038

APA

Kangas, S. T., Kæstel, P., Salpéteur, C., Nikièma, V., Talley, L., Briend, A., ... Wells, J. C. (2020). Body composition during outpatient treatment of severe acute malnutrition: Results from a randomised trial testing different doses of ready-to-use therapeutic foods. Clinical Nutrition. https://doi.org/10.1016/j.clnu.2020.02.038

Vancouver

Kangas ST, Kæstel P, Salpéteur C, Nikièma V, Talley L, Briend A o.a. Body composition during outpatient treatment of severe acute malnutrition: Results from a randomised trial testing different doses of ready-to-use therapeutic foods. Clinical Nutrition. 2020 mar 6. https://doi.org/10.1016/j.clnu.2020.02.038

Author

Kangas, Suvi T ; Kæstel, Pernille ; Salpéteur, Cécile ; Nikièma, Victor ; Talley, Leisel ; Briend, André ; Ritz, Christian ; Friis, Henrik ; Wells, Jonathan C. / Body composition during outpatient treatment of severe acute malnutrition : Results from a randomised trial testing different doses of ready-to-use therapeutic foods. I: Clinical Nutrition. 2020.

Bibtex

@article{b31f9d34df3c4047bd6a2264b141a8ac,
title = "Body composition during outpatient treatment of severe acute malnutrition: Results from a randomised trial testing different doses of ready-to-use therapeutic foods",
abstract = "Background & Aims: Treatment of children with uncomplicated severe acute malnutrition (SAM) is based on ready-to-use therapeutic foods (RUTF) prescribed based on body weight and administered at home. Treatment performance is typically monitored through weight gain. We previously reported that a reduced dose of RUTF resulted in weight gain velocity similar to standard dose. Here we investigate the change in body composition of children treated for SAM and compare it to community controls, and describe the effect of a reduced RUTF dose on body composition at recovery.Methods: Body composition was measured via bio-electrical impedance analysis at admission and recovery among a sub-group of children with SAM participating in a clinical trial and receiving a reduced or a standard dose of RUTF. Non-malnourished children were measured to represent community controls. Linear mixed regression models were fitted.Results: We obtained body composition data from 452 children at admission, 259 at recovery and 97 community controls. During SAM treatment the average weight increased by 1.20 kg of which 0.55 kg (45{\%}) was fat-free mass (FFM) and 0.67 kg (55{\%}) was fat mass (FM). At recovery, children treated for SAM had 1.27 kg lower weight, 0.38 kg lower FFM, and 0.90 kg lower FM compared to community controls. However, their fat-free mass index (FFMI) was not different from community controls (Δ0.2 kg/m2; 95{\%} CI -0.1, 0.4). No differences were observed in FFM, FM or fat mass index (FMI) between the study arms at recovery. However, FFMI was 0.35 kg/m2 higher at recovery with the reduced compared to standard dose (p = 0.007) due to slightly lower height (Δ0.22 cm; p = 0.25) and higher FFM (Δ0.11 kg; p = 0.078) in the reduced dose group.Conclusions: Almost half of the weight gain during SAM treatment was FFM. Compared to community controls, children recovered from SAM had a lower FM while their height-adjusted FFM was similar. There was no evidence of a differential effect of a reduced RUTF dose on the tissue accretion of treated children when compared to standard treatment.",
keywords = "Faculty of Science, Body composition, Bioelectrical impedance analysis, Severe acute malnutrition, Children, Ready-to-use therapeutic food, Burkina Faso",
author = "Kangas, {Suvi T} and Pernille K{\ae}stel and C{\'e}cile Salp{\'e}teur and Victor Niki{\`e}ma and Leisel Talley and Andr{\'e} Briend and Christian Ritz and Henrik Friis and Wells, {Jonathan C}",
note = "Copyright {\circledC} 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.",
year = "2020",
month = "3",
day = "6",
doi = "10.1016/j.clnu.2020.02.038",
language = "English",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Body composition during outpatient treatment of severe acute malnutrition

T2 - Results from a randomised trial testing different doses of ready-to-use therapeutic foods

AU - Kangas, Suvi T

AU - Kæstel, Pernille

AU - Salpéteur, Cécile

AU - Nikièma, Victor

AU - Talley, Leisel

AU - Briend, André

AU - Ritz, Christian

AU - Friis, Henrik

AU - Wells, Jonathan C

N1 - Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

PY - 2020/3/6

Y1 - 2020/3/6

N2 - Background & Aims: Treatment of children with uncomplicated severe acute malnutrition (SAM) is based on ready-to-use therapeutic foods (RUTF) prescribed based on body weight and administered at home. Treatment performance is typically monitored through weight gain. We previously reported that a reduced dose of RUTF resulted in weight gain velocity similar to standard dose. Here we investigate the change in body composition of children treated for SAM and compare it to community controls, and describe the effect of a reduced RUTF dose on body composition at recovery.Methods: Body composition was measured via bio-electrical impedance analysis at admission and recovery among a sub-group of children with SAM participating in a clinical trial and receiving a reduced or a standard dose of RUTF. Non-malnourished children were measured to represent community controls. Linear mixed regression models were fitted.Results: We obtained body composition data from 452 children at admission, 259 at recovery and 97 community controls. During SAM treatment the average weight increased by 1.20 kg of which 0.55 kg (45%) was fat-free mass (FFM) and 0.67 kg (55%) was fat mass (FM). At recovery, children treated for SAM had 1.27 kg lower weight, 0.38 kg lower FFM, and 0.90 kg lower FM compared to community controls. However, their fat-free mass index (FFMI) was not different from community controls (Δ0.2 kg/m2; 95% CI -0.1, 0.4). No differences were observed in FFM, FM or fat mass index (FMI) between the study arms at recovery. However, FFMI was 0.35 kg/m2 higher at recovery with the reduced compared to standard dose (p = 0.007) due to slightly lower height (Δ0.22 cm; p = 0.25) and higher FFM (Δ0.11 kg; p = 0.078) in the reduced dose group.Conclusions: Almost half of the weight gain during SAM treatment was FFM. Compared to community controls, children recovered from SAM had a lower FM while their height-adjusted FFM was similar. There was no evidence of a differential effect of a reduced RUTF dose on the tissue accretion of treated children when compared to standard treatment.

AB - Background & Aims: Treatment of children with uncomplicated severe acute malnutrition (SAM) is based on ready-to-use therapeutic foods (RUTF) prescribed based on body weight and administered at home. Treatment performance is typically monitored through weight gain. We previously reported that a reduced dose of RUTF resulted in weight gain velocity similar to standard dose. Here we investigate the change in body composition of children treated for SAM and compare it to community controls, and describe the effect of a reduced RUTF dose on body composition at recovery.Methods: Body composition was measured via bio-electrical impedance analysis at admission and recovery among a sub-group of children with SAM participating in a clinical trial and receiving a reduced or a standard dose of RUTF. Non-malnourished children were measured to represent community controls. Linear mixed regression models were fitted.Results: We obtained body composition data from 452 children at admission, 259 at recovery and 97 community controls. During SAM treatment the average weight increased by 1.20 kg of which 0.55 kg (45%) was fat-free mass (FFM) and 0.67 kg (55%) was fat mass (FM). At recovery, children treated for SAM had 1.27 kg lower weight, 0.38 kg lower FFM, and 0.90 kg lower FM compared to community controls. However, their fat-free mass index (FFMI) was not different from community controls (Δ0.2 kg/m2; 95% CI -0.1, 0.4). No differences were observed in FFM, FM or fat mass index (FMI) between the study arms at recovery. However, FFMI was 0.35 kg/m2 higher at recovery with the reduced compared to standard dose (p = 0.007) due to slightly lower height (Δ0.22 cm; p = 0.25) and higher FFM (Δ0.11 kg; p = 0.078) in the reduced dose group.Conclusions: Almost half of the weight gain during SAM treatment was FFM. Compared to community controls, children recovered from SAM had a lower FM while their height-adjusted FFM was similar. There was no evidence of a differential effect of a reduced RUTF dose on the tissue accretion of treated children when compared to standard treatment.

KW - Faculty of Science

KW - Body composition

KW - Bioelectrical impedance analysis

KW - Severe acute malnutrition

KW - Children

KW - Ready-to-use therapeutic food

KW - Burkina Faso

U2 - 10.1016/j.clnu.2020.02.038

DO - 10.1016/j.clnu.2020.02.038

M3 - Journal article

C2 - 32184026

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

ER -

ID: 237798775