An isocaloric Nordic diet modulates RELA and TNFRSF1A gene expression in peripheral blood mononuclear cells in individuals with metabolic syndrome - a SYSDIET sub-study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt


  • Stine M Ulven
  • Kirsten B Holven
  • Amanda Rundblad
  • Mari C W Myhrstad
  • Lena Leder
  • Ingrid Dahlman
  • Vanessa D de Mello
  • Ursula Schwab
  • Carsten Carlberg
  • Jussi Pihlajamäki
  • Kjeld Hermansen
  • Ingibjörg Gunnarsdottir
  • Lieselotte Cloetens
  • Björn Åkesson
  • Fredrik Rosqvist
  • Janne Hukkanen
  • Karl-Heinz Herzig
  • Markku J Savolainen
  • Ulf Risérus
  • Inga Thorsdottir
  • Kaisa S Poutanen
  • Peter Arner
  • Matti Uusitupa
  • Marjukka Kolehmainen

A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.

Udgave nummer12
Antal sider11
StatusUdgivet - 2019

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CURIS 2019 NEXS 404

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