TY - JOUR

T1 - What is the profile of overweight individuals who are unsuccessful responders to a low-energy diet? A PREVIEW sub-study

AU - Tremblay, Angelo

AU - Fogelholm, Mikael

AU - Jalo, Elli

AU - Westerterp-Plantenga, Margriet S

AU - Adam, Tanja C

AU - Huttunen-Lenz, Maija

AU - Stratton, Gareth

AU - Lam, Tony

AU - Handjieva-Darlenska, Teodora

AU - Handjiev, Svetoslav

AU - Martinez, J Alfredo

AU - Macdonald, Ian A

AU - Simpson, Elizabeth J

AU - Brand-Miller, Jennie

AU - Muirhead, Roslyn

AU - Poppitt, Sally D

AU - Silvestre, Marta P

AU - Larsen, Thomas Meinert

AU - Vestentoft, Pia Siig

AU - Schlicht, Wolfgang

AU - Drapeau, Vicky

AU - Raben, Anne

N1 - CURIS 2021 NEXS 341

PY - 2021

Y1 - 2021

N2 - This study was performed to evaluate the profile of overweight individuals withpre-diabetes enrolled in PREVIEW who were unable to achieve a body weight lossof ≥8% of the baseline value in response to a 2-month low-energy diet (LED). Their baseline profile reflected potential stress-related vulnerability that predicted a reduced response of body weight to a LED programme. The mean daily energy deficit maintained by unsuccessful weight responders of both sexes was less than the estimated level in successful female (656 vs. 1,299 kcal, p < 0.01) and male (815 vs. 1,659 kcal, p < 0.01) responders. Despite this smaller energy deficit, unsuccessful responders displayed less favorable changes in susceptibility to hunger and appetite sensations. They also did not benefit from the intervention regarding the ability to improve sleep quality. In summary, these results show that some individuals display a behavioral vulnerability which mayreduce the ability to lose weight in response to a diet-based weight loss program. They also suggest that this vulnerability may be accentuated by a prolonged diet restriction.

AB - This study was performed to evaluate the profile of overweight individuals withpre-diabetes enrolled in PREVIEW who were unable to achieve a body weight lossof ≥8% of the baseline value in response to a 2-month low-energy diet (LED). Their baseline profile reflected potential stress-related vulnerability that predicted a reduced response of body weight to a LED programme. The mean daily energy deficit maintained by unsuccessful weight responders of both sexes was less than the estimated level in successful female (656 vs. 1,299 kcal, p < 0.01) and male (815 vs. 1,659 kcal, p < 0.01) responders. Despite this smaller energy deficit, unsuccessful responders displayed less favorable changes in susceptibility to hunger and appetite sensations. They also did not benefit from the intervention regarding the ability to improve sleep quality. In summary, these results show that some individuals display a behavioral vulnerability which mayreduce the ability to lose weight in response to a diet-based weight loss program. They also suggest that this vulnerability may be accentuated by a prolonged diet restriction.

KW - Faculty of Science

KW - Obesity

KW - Behavior

KW - Energy

KW - Hunger

KW - Appetite

KW - Sleep

U2 - 10.3389/fnut.2021.707682

DO - 10.3389/fnut.2021.707682

M3 - Journal article

C2 - 34796192

VL - 8

JO - Frontiers in Nutrition

JF - Frontiers in Nutrition

SN - 2296-861X

M1 - 707682

ER -