The emerging roles of nicotinamide adenine dinucleotide phosphate oxidase 2 in skeletal muscle redox signaling and metabolism

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Standard

The emerging roles of nicotinamide adenine dinucleotide phosphate oxidase 2 in skeletal muscle redox signaling and metabolism. / Henríquez-Olguín, Carlos; Boronat, Susanna; Cabello-Verrugio, Claudio; Jaimovich, Enrique; Hidalgo, Elena; Jensen, Thomas Elbenhardt.

I: Antioxidants & Redox Signaling, Bind 31, Nr. 8, 2019, s. 1371-1410.

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Harvard

Henríquez-Olguín, C, Boronat, S, Cabello-Verrugio, C, Jaimovich, E, Hidalgo, E & Jensen, TE 2019, 'The emerging roles of nicotinamide adenine dinucleotide phosphate oxidase 2 in skeletal muscle redox signaling and metabolism', Antioxidants & Redox Signaling, bind 31, nr. 8, s. 1371-1410. https://doi.org/10.1089/ars.2018.7678

APA

Henríquez-Olguín, C., Boronat, S., Cabello-Verrugio, C., Jaimovich, E., Hidalgo, E., & Jensen, T. E. (2019). The emerging roles of nicotinamide adenine dinucleotide phosphate oxidase 2 in skeletal muscle redox signaling and metabolism. Antioxidants & Redox Signaling, 31(8), 1371-1410. https://doi.org/10.1089/ars.2018.7678

Vancouver

Henríquez-Olguín C, Boronat S, Cabello-Verrugio C, Jaimovich E, Hidalgo E, Jensen TE. The emerging roles of nicotinamide adenine dinucleotide phosphate oxidase 2 in skeletal muscle redox signaling and metabolism. Antioxidants & Redox Signaling. 2019;31(8):1371-1410. https://doi.org/10.1089/ars.2018.7678

Author

Henríquez-Olguín, Carlos ; Boronat, Susanna ; Cabello-Verrugio, Claudio ; Jaimovich, Enrique ; Hidalgo, Elena ; Jensen, Thomas Elbenhardt. / The emerging roles of nicotinamide adenine dinucleotide phosphate oxidase 2 in skeletal muscle redox signaling and metabolism. I: Antioxidants & Redox Signaling. 2019 ; Bind 31, Nr. 8. s. 1371-1410.

Bibtex

@article{28b7c56ef5f3482eacd9067b77be8fdb,
title = "The emerging roles of nicotinamide adenine dinucleotide phosphate oxidase 2 in skeletal muscle redox signaling and metabolism",
abstract = "Significance: Skeletal muscle is a crucial tissue to whole-body locomotion and metabolic health. Reactive oxygen species (ROS) have emerged as intracellular messengers participating in both physiological and pathological adaptations in skeletal muscle. A complex interplay between ROS-producing enzymes and antioxidant networks exists in different subcellular compartments of mature skeletal muscle. Recent evidence suggests that NADPH oxidases (NOX) are a major source of contraction- and insulin-stimulated oxidants production, but may paradoxically also contribute to muscle insulin resistance and atrophy.Recent advances: Pharmacological and molecular biological tools, including redox-sensitive probes and transgenic mouse models, have generated novel insights into compartmentalized redox signaling and suggested that NOX2 contributes to redox control of skeletal muscle metabolism. Critical issues: Major outstanding questions in skeletal muscle include where NOX2 activation occurs under different conditions in health and disease, how NOX2 activation is regulated, how superoxide/ H2O2 generated by NOX2 reaches the cytosol, what the signaling mediators are downstream of NOX2, and the role of NOX2 for different physiological and pathophysiological processes. Future directions: Future research should utilize and expand the current redox-signaling toolbox to clarify the NOX2-dependent mechanisms in skeletal muscle and determine whether the proposed functions of NOX2 in cells and animal models are conserved into man.",
keywords = "Faculty of Science, Exercise, Skeletal muscle, Glucose metabolism, Insulin resistance, Atrophy",
author = "Carlos Henr{\'i}quez-Olgu{\'i}n and Susanna Boronat and Claudio Cabello-Verrugio and Enrique Jaimovich and Elena Hidalgo and Jensen, {Thomas Elbenhardt}",
note = "CURIS 2019 NEXS 347",
year = "2019",
doi = "10.1089/ars.2018.7678",
language = "English",
volume = "31",
pages = "1371--1410",
journal = "Antioxidants & Redox Signaling",
issn = "1523-0864",
publisher = "Mary AnnLiebert, Inc. Publishers",
number = "8",

}

RIS

TY - JOUR

T1 - The emerging roles of nicotinamide adenine dinucleotide phosphate oxidase 2 in skeletal muscle redox signaling and metabolism

AU - Henríquez-Olguín, Carlos

AU - Boronat, Susanna

AU - Cabello-Verrugio, Claudio

AU - Jaimovich, Enrique

AU - Hidalgo, Elena

AU - Jensen, Thomas Elbenhardt

N1 - CURIS 2019 NEXS 347

PY - 2019

Y1 - 2019

N2 - Significance: Skeletal muscle is a crucial tissue to whole-body locomotion and metabolic health. Reactive oxygen species (ROS) have emerged as intracellular messengers participating in both physiological and pathological adaptations in skeletal muscle. A complex interplay between ROS-producing enzymes and antioxidant networks exists in different subcellular compartments of mature skeletal muscle. Recent evidence suggests that NADPH oxidases (NOX) are a major source of contraction- and insulin-stimulated oxidants production, but may paradoxically also contribute to muscle insulin resistance and atrophy.Recent advances: Pharmacological and molecular biological tools, including redox-sensitive probes and transgenic mouse models, have generated novel insights into compartmentalized redox signaling and suggested that NOX2 contributes to redox control of skeletal muscle metabolism. Critical issues: Major outstanding questions in skeletal muscle include where NOX2 activation occurs under different conditions in health and disease, how NOX2 activation is regulated, how superoxide/ H2O2 generated by NOX2 reaches the cytosol, what the signaling mediators are downstream of NOX2, and the role of NOX2 for different physiological and pathophysiological processes. Future directions: Future research should utilize and expand the current redox-signaling toolbox to clarify the NOX2-dependent mechanisms in skeletal muscle and determine whether the proposed functions of NOX2 in cells and animal models are conserved into man.

AB - Significance: Skeletal muscle is a crucial tissue to whole-body locomotion and metabolic health. Reactive oxygen species (ROS) have emerged as intracellular messengers participating in both physiological and pathological adaptations in skeletal muscle. A complex interplay between ROS-producing enzymes and antioxidant networks exists in different subcellular compartments of mature skeletal muscle. Recent evidence suggests that NADPH oxidases (NOX) are a major source of contraction- and insulin-stimulated oxidants production, but may paradoxically also contribute to muscle insulin resistance and atrophy.Recent advances: Pharmacological and molecular biological tools, including redox-sensitive probes and transgenic mouse models, have generated novel insights into compartmentalized redox signaling and suggested that NOX2 contributes to redox control of skeletal muscle metabolism. Critical issues: Major outstanding questions in skeletal muscle include where NOX2 activation occurs under different conditions in health and disease, how NOX2 activation is regulated, how superoxide/ H2O2 generated by NOX2 reaches the cytosol, what the signaling mediators are downstream of NOX2, and the role of NOX2 for different physiological and pathophysiological processes. Future directions: Future research should utilize and expand the current redox-signaling toolbox to clarify the NOX2-dependent mechanisms in skeletal muscle and determine whether the proposed functions of NOX2 in cells and animal models are conserved into man.

KW - Faculty of Science

KW - Exercise

KW - Skeletal muscle

KW - Glucose metabolism

KW - Insulin resistance

KW - Atrophy

U2 - 10.1089/ars.2018.7678

DO - 10.1089/ars.2018.7678

M3 - Review

C2 - 31588777

VL - 31

SP - 1371

EP - 1410

JO - Antioxidants & Redox Signaling

JF - Antioxidants & Redox Signaling

SN - 1523-0864

IS - 8

ER -

ID: 230478214