The effects of dietary supplementation with n-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial

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G L Nielsen, K L Faarvang, B S Thomsen, K L Teglbjaerg, L T Jensen, T M Hansen, H H Lervang, E B Schmidt, J Dyerberg, E Ernst

STUDY OBJECTIVE: To determine the effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with rheumatoid arthritis.

DESIGN: Multicenter, randomized, placebo controlled, double blind.

SETTING: Three Danish hospital Departments of Rheumatology.

PATIENTS: Fifty-one patients with active rheumatoid arthritis.

INTERVENTION: Random allocation to 12 weeks of treatment with either six n-3 PUFA capsules (3.6 g) or six capsules with fat composition as the average Danish diet.

MAIN RESULTS: Significant improvement of morning stiffness and joint tenderness. No significant effect on the four other assessed clinical parameters. No serious side effects.

CONCLUSIONS: Dietary supplementation with n-3 PUFA in patients with rheumatoid arthritis improved two out of six patient reported disease parameters. Further studies are needed to clarify the more precise role of n-3 PUFA in the treatment of rheumatoid arthritis.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Investigation
Vol/bind22
Udgave nummer10
Sider (fra-til)687-91
Antal sider5
ISSN0014-2972
StatusUdgivet - okt. 1992

ID: 168819452