The effects of dietary supplementation with n-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial
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Abstract. Study objective: To determine the effect of dietary
supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on
disease variables in patients with rheumatoid arthritis. Design:
Multicenter, randomized, placebo controlled, double blind. Setting:
Three Danish hospital Departments of Rheumatology. Patients: Fifty-one
patients with active rheumatoid arthritis. Intervention: Random
allocation to 12 weeks of treatment with either six n-3 PUFA capsules
(3–6 g) or six capsules with fat composition as the average Danish diet.
Main results: Significant improvement of morning stiffness and joint
tenderness. No significant effect on the four other assessed clinical
parameters. No serious side effects. Conclusions: Dietary
supplementation with n-3 PUFA in patients with rheumatoid arthritis
improved two out of six patient reported disease parameters. Further
studies are needed to clarify the more precise role of n-3 PUFA in the
treatment of rheumatoid arthritis.
Originalsprog | Engelsk |
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Tidsskrift | European Journal of Clinical Investigation |
Vol/bind | 22 |
Udgave nummer | 10 |
Sider (fra-til) | 687-691 |
Antal sider | 5 |
ISSN | 0014-2972 |
DOI | |
Status | Udgivet - 1992 |
Eksternt udgivet | Ja |
ID: 168819452