Sedentarism, physical activity, steps, and neurotrophic factors in obese children

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Sedentarism, physical activity, steps, and neurotrophic factors in obese children. / Mora-Gonzalez, Jose; Migueles, Jairo H; Esteban-Cornejo, Irene; Cadenas-Sanchez, Cristina; Pastor-Villaescusa, Belén; Molina-García, Pablo; Rodriguez-Ayllon, María; Rico, María C; Gil, Angel; Aguilera, Concepción M; Escolano-Margarit, María Victoria; Gejl, Anne Kær; Andersen, Lars Bo; Catena, Andrés; Ortega, Francisco B.

I: Medicine and Science in Sports and Exercise, Bind 51, Nr. 11, 2019, s. 2325-2333.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Mora-Gonzalez, J, Migueles, JH, Esteban-Cornejo, I, Cadenas-Sanchez, C, Pastor-Villaescusa, B, Molina-García, P, Rodriguez-Ayllon, M, Rico, MC, Gil, A, Aguilera, CM, Escolano-Margarit, MV, Gejl, AK, Andersen, LB, Catena, A & Ortega, FB 2019, 'Sedentarism, physical activity, steps, and neurotrophic factors in obese children', Medicine and Science in Sports and Exercise, bind 51, nr. 11, s. 2325-2333. https://doi.org/10.1249/MSS.0000000000002064

APA

Mora-Gonzalez, J., Migueles, J. H., Esteban-Cornejo, I., Cadenas-Sanchez, C., Pastor-Villaescusa, B., Molina-García, P., Rodriguez-Ayllon, M., Rico, M. C., Gil, A., Aguilera, C. M., Escolano-Margarit, M. V., Gejl, A. K., Andersen, L. B., Catena, A., & Ortega, F. B. (2019). Sedentarism, physical activity, steps, and neurotrophic factors in obese children. Medicine and Science in Sports and Exercise, 51(11), 2325-2333. https://doi.org/10.1249/MSS.0000000000002064

Vancouver

Mora-Gonzalez J, Migueles JH, Esteban-Cornejo I, Cadenas-Sanchez C, Pastor-Villaescusa B, Molina-García P o.a. Sedentarism, physical activity, steps, and neurotrophic factors in obese children. Medicine and Science in Sports and Exercise. 2019;51(11):2325-2333. https://doi.org/10.1249/MSS.0000000000002064

Author

Mora-Gonzalez, Jose ; Migueles, Jairo H ; Esteban-Cornejo, Irene ; Cadenas-Sanchez, Cristina ; Pastor-Villaescusa, Belén ; Molina-García, Pablo ; Rodriguez-Ayllon, María ; Rico, María C ; Gil, Angel ; Aguilera, Concepción M ; Escolano-Margarit, María Victoria ; Gejl, Anne Kær ; Andersen, Lars Bo ; Catena, Andrés ; Ortega, Francisco B. / Sedentarism, physical activity, steps, and neurotrophic factors in obese children. I: Medicine and Science in Sports and Exercise. 2019 ; Bind 51, Nr. 11. s. 2325-2333.

Bibtex

@article{f30ac9cb84cf474e97d0c216bd574e77,
title = "Sedentarism, physical activity, steps, and neurotrophic factors in obese children",
abstract = "Purpose: This study aimed to examine the associations of sedentary time, physical activity (PA) and step-related behaviors with neurotrophic growth factors.Methods: A total of 97 children with overweight/obesity age 8 to 11 yr participated in this study. Sedentary time, PA, and steps were measured by GT3X+ accelerometers in hip and nondominant wrist. Estimates of light, moderate, vigorous, and moderate-to-vigorous PA (MVPA) were obtained. Steps per daytime, peak 60-, 30-, and 1-min cadence were computed. The time accumulated (min·d) in different cadence bands of steps was also computed from hip accelerometer. Plasma levels of brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and insulin growth factor-1 (IGF-1) were determined by the XMap technology (Luminex IS 100/200 system, Luminex Corporation, Austin, TX).Results: Light PA, moderate PA, MVPA, and the peak 60-min cadence were positively related with BDNF concentrations (all P < 0.05), and only light PA to VEGF (P = 0.048). No association was observed for IGF-1 (P > 0.05). The associations of light PA with BDNF and VEGF disappeared (all P > 0.05) after performing analyses with nondominant wrist-placement data. However, moderate PA and MVPA remained significantly associated with BDNF (both P < 0.05). The time accumulated in cadence bands of 40 to 59 steps per day and 60 to 79 steps per day (i.e., walking at slow pace) was positively associated with plasma BDNF (all P < 0.05).Conclusions: In conclusion, PA is positively related to plasma BDNF, whereas no relationship was observed for VEGF or IGF-1. Higher amounts of time spent in slow walking cadence bands could increment BDNF levels. Exercise-based randomized controlled trials in children with overweight/obesity should be carried out to better understand the influence of PA behaviors on the neurotrophic factors.",
keywords = "Faculty of Science, Accelerometry, BDNF, Cognition, Obesity, Walking, Youth",
author = "Jose Mora-Gonzalez and Migueles, {Jairo H} and Irene Esteban-Cornejo and Cristina Cadenas-Sanchez and Bel{\'e}n Pastor-Villaescusa and Pablo Molina-Garc{\'i}a and Mar{\'i}a Rodriguez-Ayllon and Rico, {Mar{\'i}a C} and Angel Gil and Aguilera, {Concepci{\'o}n M} and Escolano-Margarit, {Mar{\'i}a Victoria} and Gejl, {Anne K{\ae}r} and Andersen, {Lars Bo} and Andr{\'e}s Catena and Ortega, {Francisco B}",
note = "(Ekstern)",
year = "2019",
doi = "10.1249/MSS.0000000000002064",
language = "English",
volume = "51",
pages = "2325--2333",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams & Wilkins",
number = "11",

}

RIS

TY - JOUR

T1 - Sedentarism, physical activity, steps, and neurotrophic factors in obese children

AU - Mora-Gonzalez, Jose

AU - Migueles, Jairo H

AU - Esteban-Cornejo, Irene

AU - Cadenas-Sanchez, Cristina

AU - Pastor-Villaescusa, Belén

AU - Molina-García, Pablo

AU - Rodriguez-Ayllon, María

AU - Rico, María C

AU - Gil, Angel

AU - Aguilera, Concepción M

AU - Escolano-Margarit, María Victoria

AU - Gejl, Anne Kær

AU - Andersen, Lars Bo

AU - Catena, Andrés

AU - Ortega, Francisco B

N1 - (Ekstern)

PY - 2019

Y1 - 2019

N2 - Purpose: This study aimed to examine the associations of sedentary time, physical activity (PA) and step-related behaviors with neurotrophic growth factors.Methods: A total of 97 children with overweight/obesity age 8 to 11 yr participated in this study. Sedentary time, PA, and steps were measured by GT3X+ accelerometers in hip and nondominant wrist. Estimates of light, moderate, vigorous, and moderate-to-vigorous PA (MVPA) were obtained. Steps per daytime, peak 60-, 30-, and 1-min cadence were computed. The time accumulated (min·d) in different cadence bands of steps was also computed from hip accelerometer. Plasma levels of brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and insulin growth factor-1 (IGF-1) were determined by the XMap technology (Luminex IS 100/200 system, Luminex Corporation, Austin, TX).Results: Light PA, moderate PA, MVPA, and the peak 60-min cadence were positively related with BDNF concentrations (all P < 0.05), and only light PA to VEGF (P = 0.048). No association was observed for IGF-1 (P > 0.05). The associations of light PA with BDNF and VEGF disappeared (all P > 0.05) after performing analyses with nondominant wrist-placement data. However, moderate PA and MVPA remained significantly associated with BDNF (both P < 0.05). The time accumulated in cadence bands of 40 to 59 steps per day and 60 to 79 steps per day (i.e., walking at slow pace) was positively associated with plasma BDNF (all P < 0.05).Conclusions: In conclusion, PA is positively related to plasma BDNF, whereas no relationship was observed for VEGF or IGF-1. Higher amounts of time spent in slow walking cadence bands could increment BDNF levels. Exercise-based randomized controlled trials in children with overweight/obesity should be carried out to better understand the influence of PA behaviors on the neurotrophic factors.

AB - Purpose: This study aimed to examine the associations of sedentary time, physical activity (PA) and step-related behaviors with neurotrophic growth factors.Methods: A total of 97 children with overweight/obesity age 8 to 11 yr participated in this study. Sedentary time, PA, and steps were measured by GT3X+ accelerometers in hip and nondominant wrist. Estimates of light, moderate, vigorous, and moderate-to-vigorous PA (MVPA) were obtained. Steps per daytime, peak 60-, 30-, and 1-min cadence were computed. The time accumulated (min·d) in different cadence bands of steps was also computed from hip accelerometer. Plasma levels of brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and insulin growth factor-1 (IGF-1) were determined by the XMap technology (Luminex IS 100/200 system, Luminex Corporation, Austin, TX).Results: Light PA, moderate PA, MVPA, and the peak 60-min cadence were positively related with BDNF concentrations (all P < 0.05), and only light PA to VEGF (P = 0.048). No association was observed for IGF-1 (P > 0.05). The associations of light PA with BDNF and VEGF disappeared (all P > 0.05) after performing analyses with nondominant wrist-placement data. However, moderate PA and MVPA remained significantly associated with BDNF (both P < 0.05). The time accumulated in cadence bands of 40 to 59 steps per day and 60 to 79 steps per day (i.e., walking at slow pace) was positively associated with plasma BDNF (all P < 0.05).Conclusions: In conclusion, PA is positively related to plasma BDNF, whereas no relationship was observed for VEGF or IGF-1. Higher amounts of time spent in slow walking cadence bands could increment BDNF levels. Exercise-based randomized controlled trials in children with overweight/obesity should be carried out to better understand the influence of PA behaviors on the neurotrophic factors.

KW - Faculty of Science

KW - Accelerometry

KW - BDNF

KW - Cognition

KW - Obesity

KW - Walking

KW - Youth

U2 - 10.1249/MSS.0000000000002064

DO - 10.1249/MSS.0000000000002064

M3 - Journal article

C2 - 31634295

VL - 51

SP - 2325

EP - 2333

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 11

ER -

ID: 229060847