Physiological and lifestyle traits of metabolic dysfunction in the absence of obesity

Publikation: Bidrag til tidsskriftReviewfagfællebedømt

Standard

Physiological and lifestyle traits of metabolic dysfunction in the absence of obesity. / Klitgaard, Hanna Bjørk; Kilbak, Jesper Hoffmann; Nozawa, Erica Arhnung; Seidel, Ann V; Magkos, Faidon.

I: Current Diabetes Reports, Bind 20, Nr. 6, 17, 2020.

Publikation: Bidrag til tidsskriftReviewfagfællebedømt

Harvard

Klitgaard, HB, Kilbak, JH, Nozawa, EA, Seidel, AV & Magkos, F 2020, 'Physiological and lifestyle traits of metabolic dysfunction in the absence of obesity', Current Diabetes Reports, bind 20, nr. 6, 17. https://doi.org/10.1007/s11892-020-01302-2

APA

Klitgaard, H. B., Kilbak, J. H., Nozawa, E. A., Seidel, A. V., & Magkos, F. (2020). Physiological and lifestyle traits of metabolic dysfunction in the absence of obesity. Current Diabetes Reports, 20(6), [17]. https://doi.org/10.1007/s11892-020-01302-2

Vancouver

Klitgaard HB, Kilbak JH, Nozawa EA, Seidel AV, Magkos F. Physiological and lifestyle traits of metabolic dysfunction in the absence of obesity. Current Diabetes Reports. 2020;20(6). 17. https://doi.org/10.1007/s11892-020-01302-2

Author

Klitgaard, Hanna Bjørk ; Kilbak, Jesper Hoffmann ; Nozawa, Erica Arhnung ; Seidel, Ann V ; Magkos, Faidon. / Physiological and lifestyle traits of metabolic dysfunction in the absence of obesity. I: Current Diabetes Reports. 2020 ; Bind 20, Nr. 6.

Bibtex

@article{b8a5445f19f74a9fbb351ac76f7c00aa,
title = "Physiological and lifestyle traits of metabolic dysfunction in the absence of obesity",
abstract = "Purpose of review: Individuals with metabolically unhealthy normal weight (MUNW) have an adverse cardiometabolic risk factor profile in the absence of excess body weight, and increased risk for diabetes and heart disease. We critically review some physiological traits and lifestyle characteristics of the MUNW phenotype.Recent findings: The prevalence of MUNW varies considerably around the world and among ethnicities, partly because of different definitions; on average, this phenotype affects about ~ 30% of normal weight persons globally. Most studies have recruited MUNW subjects who, although within the normal weight range, are significantly {"}more obese{"} than their metabolically healthy lean peers (greater body mass index or total body fat); hence one cannot ascertain whether observed differences are true traits of the MUNW phenotype of simply secondary to greater relative adiposity within the normal range. Carefully matched studies have indicated that MUNW can exist in the absence of excess total body fat. These subjects have a preferential accumulation of fat in the upper body (abdominal subcutaneous and visceral adipose tissues) and the liver, but not skeletal muscle; perhaps surprisingly, this predominantly {"}android{"} fat distribution does not translate into increased waist circumference. The MUNW phenotype is associated with lower aerobic fitness and muscle mass and strength, but whether this is simply due to inadequate regular physical activity is not entirely clear. Likewise, no consistent associations have been found between any dietary factors and the development of MUNW phenotype, but diet-induced modest weight loss facilitates its resolution. Summary: Delineating the mechanisms leading to metabolic dysfunction in the absence of increased body weight and body fat will likely reveal important targets for improving metabolic health and eventually for reducing the burden of cardiometabolic disease, not only in individuals with normal body weight but also in people with obesity.",
keywords = "Faculty of Science, Metabolic disease, Cardiometabolic risk, Body fat distribution, Metabolically obese normal weight, Metabolically abnormal lean",
author = "Klitgaard, {Hanna Bj{\o}rk} and Kilbak, {Jesper Hoffmann} and Nozawa, {Erica Arhnung} and Seidel, {Ann V} and Faidon Magkos",
note = "CURIS 2020 NEXS 129",
year = "2020",
doi = "10.1007/s11892-020-01302-2",
language = "English",
volume = "20",
journal = "Current Diabetes Reports",
issn = "1534-4827",
publisher = "Springer Healthcare",
number = "6",

}

RIS

TY - JOUR

T1 - Physiological and lifestyle traits of metabolic dysfunction in the absence of obesity

AU - Klitgaard, Hanna Bjørk

AU - Kilbak, Jesper Hoffmann

AU - Nozawa, Erica Arhnung

AU - Seidel, Ann V

AU - Magkos, Faidon

N1 - CURIS 2020 NEXS 129

PY - 2020

Y1 - 2020

N2 - Purpose of review: Individuals with metabolically unhealthy normal weight (MUNW) have an adverse cardiometabolic risk factor profile in the absence of excess body weight, and increased risk for diabetes and heart disease. We critically review some physiological traits and lifestyle characteristics of the MUNW phenotype.Recent findings: The prevalence of MUNW varies considerably around the world and among ethnicities, partly because of different definitions; on average, this phenotype affects about ~ 30% of normal weight persons globally. Most studies have recruited MUNW subjects who, although within the normal weight range, are significantly "more obese" than their metabolically healthy lean peers (greater body mass index or total body fat); hence one cannot ascertain whether observed differences are true traits of the MUNW phenotype of simply secondary to greater relative adiposity within the normal range. Carefully matched studies have indicated that MUNW can exist in the absence of excess total body fat. These subjects have a preferential accumulation of fat in the upper body (abdominal subcutaneous and visceral adipose tissues) and the liver, but not skeletal muscle; perhaps surprisingly, this predominantly "android" fat distribution does not translate into increased waist circumference. The MUNW phenotype is associated with lower aerobic fitness and muscle mass and strength, but whether this is simply due to inadequate regular physical activity is not entirely clear. Likewise, no consistent associations have been found between any dietary factors and the development of MUNW phenotype, but diet-induced modest weight loss facilitates its resolution. Summary: Delineating the mechanisms leading to metabolic dysfunction in the absence of increased body weight and body fat will likely reveal important targets for improving metabolic health and eventually for reducing the burden of cardiometabolic disease, not only in individuals with normal body weight but also in people with obesity.

AB - Purpose of review: Individuals with metabolically unhealthy normal weight (MUNW) have an adverse cardiometabolic risk factor profile in the absence of excess body weight, and increased risk for diabetes and heart disease. We critically review some physiological traits and lifestyle characteristics of the MUNW phenotype.Recent findings: The prevalence of MUNW varies considerably around the world and among ethnicities, partly because of different definitions; on average, this phenotype affects about ~ 30% of normal weight persons globally. Most studies have recruited MUNW subjects who, although within the normal weight range, are significantly "more obese" than their metabolically healthy lean peers (greater body mass index or total body fat); hence one cannot ascertain whether observed differences are true traits of the MUNW phenotype of simply secondary to greater relative adiposity within the normal range. Carefully matched studies have indicated that MUNW can exist in the absence of excess total body fat. These subjects have a preferential accumulation of fat in the upper body (abdominal subcutaneous and visceral adipose tissues) and the liver, but not skeletal muscle; perhaps surprisingly, this predominantly "android" fat distribution does not translate into increased waist circumference. The MUNW phenotype is associated with lower aerobic fitness and muscle mass and strength, but whether this is simply due to inadequate regular physical activity is not entirely clear. Likewise, no consistent associations have been found between any dietary factors and the development of MUNW phenotype, but diet-induced modest weight loss facilitates its resolution. Summary: Delineating the mechanisms leading to metabolic dysfunction in the absence of increased body weight and body fat will likely reveal important targets for improving metabolic health and eventually for reducing the burden of cardiometabolic disease, not only in individuals with normal body weight but also in people with obesity.

KW - Faculty of Science

KW - Metabolic disease

KW - Cardiometabolic risk

KW - Body fat distribution

KW - Metabolically obese normal weight

KW - Metabolically abnormal lean

U2 - 10.1007/s11892-020-01302-2

DO - 10.1007/s11892-020-01302-2

M3 - Review

C2 - 32232577

VL - 20

JO - Current Diabetes Reports

JF - Current Diabetes Reports

SN - 1534-4827

IS - 6

M1 - 17

ER -

ID: 240978198